At a Glance
- Tasks: Lead LC-MS/MS bioanalytical programmes and solve complex analytical challenges.
- Company: Join a leading scientific organisation focused on innovative bioanalysis.
- Benefits: Competitive salary, professional development, and opportunities for mentorship.
- Other info: Collaborative environment with opportunities for career advancement.
- Why this job: Make a significant impact in bioanalysis and work with cutting-edge technologies.
- Qualifications: PhD or MSc with extensive LC-MS/MS experience and strong problem-solving skills.
The predicted salary is between 70000 - 90000 € per year.
We are seeking a Principal Scientist – LC-MS/MS Bioanalysis (PK/PD, Complex Modalities) to act as a subject matter expert across LC-MS/MS bioanalytical programmes supporting PK and PD studies. This role provides scientific leadership across multiple studies, focusing on complex problem-solving, assay strategy, and client engagement.
Key Responsibilities
- Provide scientific leadership and SME support across LC-MS/MS studies
- Lead troubleshooting of complex analytical challenges, including matrix effects, sensitivity limitations, and assay robustness
- Advise on method development, optimisation, and validation strategies
- Support study teams in resolving technical issues and ensuring consistent assay performance
- Contribute to client interactions, including scientific discussions, data interpretation, and method justification
- Support proposals, bid defences, and scientific strategy discussions
- Mentor and support development of laboratory scientists
Technical Expertise
- Strong knowledge of LC-MS/MS theory, including triple quadrupole and HRMS systems
- Experience with sample preparation techniques such as SPE, LLE, protein precipitation, and hybrid workflows
- Deep understanding of quantitative bioanalysis, including calibration strategies, selectivity, and matrix effects
- Experience with Complex Modalities: Peptides and proteins, Oligonucleotides, Antibody-drug conjugates and related conjugates
Regulatory and Client Experience
- Extensive experience working under GLP and GCP
- Strong understanding of regulatory guidance (FDA, EMA, MHRA, M10)
- Experience supporting audits and regulatory inspections
- Proven ability to lead scientific discussions with clients and defend analytical approaches and data
- Ability to communicate complex technical issues clearly and challenge client assumptions where appropriate
Qualifications and Experience
- PhD in Analytical Chemistry or related field, or MSc with significant industry experience
- 10 to 15 or more years of LC-MS/MS bioanalysis experience
- Demonstrated expertise in method development, validation, and advanced troubleshooting
Principal Scientist – LC-MS/MS Bioanalysis (PK/PD, Complex Modalities) in Macclesfield employer: Synexa Life Sciences (Pty) Ltd.
As a Principal Scientist at our innovative bioanalytical firm, you will thrive in a collaborative and dynamic work culture that prioritises scientific excellence and employee development. We offer competitive benefits, including professional growth opportunities and a supportive environment for mentoring, all while being located in a vibrant area that fosters creativity and engagement with leading industry professionals.
Contact Detail:
Synexa Life Sciences (Pty) Ltd. Recruiting Team
StudySmarter Expert Advice🤫
We think this is how you could land Principal Scientist – LC-MS/MS Bioanalysis (PK/PD, Complex Modalities) in Macclesfield
✨Tip Number 1
Network like a pro! Reach out to your connections in the industry, attend relevant conferences, and engage in discussions on platforms like LinkedIn. We can’t stress enough how important it is to make those personal connections that could lead to job opportunities.
✨Tip Number 2
Prepare for interviews by brushing up on your technical knowledge and being ready to discuss complex problem-solving scenarios. We recommend practising with a friend or mentor to get comfortable articulating your expertise in LC-MS/MS bioanalysis.
✨Tip Number 3
Showcase your leadership skills! When discussing your experience, highlight instances where you’ve led teams or projects, especially in troubleshooting and method development. We want to see how you can bring that scientific leadership to our team.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets seen by the right people. Plus, we love seeing candidates who take the initiative to connect directly with us.
We think you need these skills to ace Principal Scientist – LC-MS/MS Bioanalysis (PK/PD, Complex Modalities) in Macclesfield
Some tips for your application 🫡
Tailor Your CV:Make sure your CV highlights your experience with LC-MS/MS bioanalysis and any relevant projects you've led. We want to see how your skills align with the role, so don’t be shy about showcasing your expertise!
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Use it to explain why you’re passionate about this role and how your background makes you the perfect fit. We love seeing enthusiasm and a clear understanding of the job!
Showcase Your Problem-Solving Skills:In your application, mention specific examples where you've tackled complex analytical challenges. We’re looking for someone who can lead troubleshooting efforts, so let us know how you’ve done this in the past!
Apply Through Our Website:We encourage you to apply directly through our website. It’s the best way for us to receive your application and ensures you’re considered for the role. Plus, it’s super easy!
How to prepare for a job interview at Synexa Life Sciences (Pty) Ltd.
✨Know Your LC-MS/MS Inside Out
Make sure you brush up on your knowledge of LC-MS/MS theory, especially around triple quadrupole and HRMS systems. Be ready to discuss specific challenges you've faced in previous roles, like matrix effects or sensitivity limitations, and how you tackled them.
✨Showcase Your Problem-Solving Skills
Prepare examples that highlight your ability to troubleshoot complex analytical challenges. Think about times when you had to optimise methods or validate strategies under pressure, and be ready to share these stories during the interview.
✨Engage with Client Scenarios
Since client engagement is key, practice discussing how you would handle scientific discussions and data interpretation with clients. Be prepared to defend your analytical approaches and challenge assumptions where necessary, showcasing your communication skills.
✨Highlight Your Mentorship Experience
As a Principal Scientist, mentoring is part of the role. Think of instances where you've supported the development of laboratory scientists. Share how you’ve guided others through method development or troubleshooting, demonstrating your leadership capabilities.
