Clinical Research Fellow

We are seeking an outstanding and highly motivated Fellow to join a multidisciplinary team investigating the metabolic adaptation of Aspergillus fumigatus during human infection and its impact on innate and adaptive immune responses. This project combines high-throughput fungal phenotyping, metabolomics, and advanced immunological assays using ex vivo human models. The post offers an exceptional opportunity to work at the interface of fungal biology, immunology, and systems-level data analysis, contributing to a programme aimed at identifying mechanisms that underpin fungal survival and immune evasion in the lung.

What you would be doing:

• Support laboratory-based experiments investigating genomic-phenotypic correlates in fumigatus clinical and environmental isolates.
• Conduct high-dimensional immunophenotyping and fungal infection assays using human whole blood and primary alveolar macrophages.
• Integrate multi‑omic datasets (metabolic, phenotypic, immunological) using computational approaches to define host–pathogen interaction networks.
• Contribute to the design, execution, and interpretation of experimental work, ensuring rigorous data quality and reproducibility.
• Work closely with collaborating groups across the Faculty of Medicine, including mycology, immunology, and computational biology teams.
• Prepare manuscripts for publication, present findings at conferences, and contribute to grant development.
• Support supervision of students and junior researchers in the laboratory.

What we are looking for:

• Clinically qualified (MBBS or equivalent)
• GMC registration
• Membership of the Royal College of Physicians, or equivalent
• Significant clinical experience in general internal medicine and the management of infections
• Understanding of good data management, reproducible research, research governance and responsible use of patient-linked datasets

What we can offer you:

• World‑class research environment
• Access to state‑of‑the‑art facilities including advanced flow cytometry platforms, CL2 mycology laboratories, and computational infrastructure for multi‑omic data analysis.
• Integration within a vibrant multidisciplinary team spanning fungal biology, immunology, systems biology, and clinical infectious diseases.
• Career development and training tailored development plans and regular mentoring by senior investigators.
• Opportunities to attend internal and external training courses, including advanced microscopy, flow cytometry, bioinformatics, machine learning, and leadership development.
• Support for presenting your work at national and international conferences and for contributing to publications and grant proposals.
• Experience supervising MSc and PhD students, building your teaching and mentorship portfolio.
• Close collaboration with clinical teams at Imperial College Healthcare and Guy’s and St. Thomas’s NHS Trust, providing unique exposure to translational infection research.
• Opportunities to engage with external partners including Crick Institute collaborators, UKRI consortia, and international fungal research networks.
• Competitive salary, sector‑leading benefits, and career development support.
• The opportunity to continue your career at a world‑leading institution and be part of our mission to continue science for humanity.
• Benefit from sector‑leading salary and remuneration package (including generous leave and pension schemes).
• Access to a range of workplace benefits including a flexible working policy, generous family leave packages, on‑site leisure facilities and a cycle‑to‑work scheme.

Further information:

• Full‑time, fixed‑term contract for 36 months

Our Culture:

We work towards equality of opportunity, to eliminating discrimination, and to creating an inclusive working environment for all. We encourage applications from all backgrounds, communities and industries, and are committed to employing a team that has diverse skills, experiences and abilities. You can read more about our commitment on our web pages.

Proud signatory of the Armed Forces Covenant. We welcome applications from the Armed Forces community.

Our values are at the root of everything we do, and everyone in our community is expected to demonstrate respect, collaboration, excellence, integrity, and innovation.