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- Tasks: Lead innovative research in cancer immunotherapy, focusing on T-cell receptor therapies.
- Company: Join a pioneering biotech company revolutionising cancer treatment through cutting-edge science.
- Benefits: Enjoy a full-time role with opportunities for collaboration and professional growth.
- Why this job: Be part of a dynamic team making a real impact in the fight against cancer.
- Qualifications: PhD in relevant fields with 2-3 years of industry experience required.
- Other info: Ideal for those passionate about advancing therapeutic candidates towards clinical development.
The predicted salary is between 43200 - 72000 £ per year.
A pioneering biotech company at the forefront of cancer immunotherapy is seeking a Senior or Principal Scientist to join their dynamic team. This organization is focused on developing next-generation T-cell receptor (TCR)-based therapies to address solid tumors—areas historically difficult to treat with conventional immunotherapies.
Role Summary
The successful candidate will play a key role in driving the engineering, in vitro, and in vivo validation of TCR-based engagers. This includes hands-on work in molecular biology, protein science, and cell-based assays, as well as collaboration across multidisciplinary teams to advance therapeutic candidates toward clinical development.
Key Responsibilities
- Lead in vitro and in vivo validation of TCR-based T cell engagers.
- Design and characterize TCRs targeting proprietary and partnered disease indications.
- Execute protein science workflows, including expression, purification, and biophysical analyses of recombinant TCRs.
- Perform molecular biology tasks: cloning, mutagenesis, DNA isolation, and library prep for sequencing.
- Manage cell culture work, including media preparation, cell line maintenance, and cryopreservation.
- Contribute to the creation, revision, and maintenance of laboratory protocols and standard operating procedures (SOPs).
Required Qualifications
- PhD in Immunology, Cell Biology, Biochemistry , or related discipline, with:
- 2-3 years of industry experience.
- Demonstrated experience with in vitro and in vivo validation of T cell engagers , ideally through to IND-enabling studies.
- Solid understanding of molecular biology techniques (e.g., cloning, PCR).
- Hands-on experience with protein expression, purification, and biophysical characterization .
- Experience with cell-based assays (e.g., flow cytometry, ELISA) is desirable.
- Familiarity with NGS library preparation and data analysis pipelines (e.g., using R) is a plus.
- Prior SOP development and documentation experience is advantageous.
Seniority level
-
Seniority level
Mid-Senior level
Employment type
-
Employment type
Full-time
Job function
-
Job function
Research and Science
-
Industries
Biotechnology Research and Pharmaceutical Manufacturing
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Principal Scientist (Oxford) employer: Skills Alliance
Contact Detail:
Skills Alliance Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Principal Scientist (Oxford)
✨Tip Number 1
Network with professionals in the biotech field, especially those working in cancer immunotherapy. Attend relevant conferences or seminars where you can meet potential colleagues and learn more about the latest advancements in TCR-based therapies.
✨Tip Number 2
Familiarise yourself with the specific molecular biology techniques mentioned in the job description, such as cloning and PCR. Consider taking online courses or workshops to enhance your practical skills and demonstrate your commitment to the role.
✨Tip Number 3
Prepare to discuss your previous experience with in vitro and in vivo validation of T cell engagers during interviews. Be ready to share specific examples of your contributions to projects and how they relate to the responsibilities outlined in the job description.
✨Tip Number 4
Research the company’s recent publications and breakthroughs in TCR-based therapies. This knowledge will not only help you understand their work better but also allow you to ask insightful questions during the interview, showcasing your genuine interest in their mission.
We think you need these skills to ace Principal Scientist (Oxford)
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights relevant experience in immunology, cell biology, and biochemistry. Emphasise any hands-on work with TCR-based therapies, molecular biology techniques, and protein science workflows.
Craft a Compelling Cover Letter: In your cover letter, express your passion for cancer immunotherapy and detail how your background aligns with the company's mission. Mention specific projects or experiences that demonstrate your expertise in TCR-based engagers.
Highlight Key Skills: Clearly outline your skills in in vitro and in vivo validation, molecular biology techniques, and protein purification. Use bullet points to make these stand out, ensuring they match the job requirements.
Showcase Collaborative Experience: Since the role involves working with multidisciplinary teams, include examples of past collaborations. Highlight how you contributed to team success and any leadership roles you may have taken on.
How to prepare for a job interview at Skills Alliance
✨Showcase Your Technical Expertise
Be prepared to discuss your hands-on experience with molecular biology techniques, protein science workflows, and cell-based assays. Highlight specific projects where you successfully validated T cell engagers, as this will demonstrate your capability to contribute effectively to their team.
✨Understand the Company’s Focus
Research the company's work in cancer immunotherapy and their approach to TCR-based therapies. Being able to articulate how your background aligns with their mission will show your genuine interest and help you stand out as a candidate.
✨Prepare for Collaborative Scenarios
Since the role involves collaboration across multidisciplinary teams, think of examples from your past experiences where you worked effectively with others. Be ready to discuss how you contributed to team success and navigated challenges in a collaborative environment.
✨Familiarise Yourself with SOPs
Given the importance of standard operating procedures in this role, review any relevant SOPs you have developed or followed in previous positions. Be prepared to discuss your experience with protocol creation and documentation, as this will be crucial for maintaining laboratory standards.
