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- Tasks: Lead innovative research in TCR-based therapies for cancer treatment.
- Company: Join a pioneering biotech firm revolutionising cancer immunotherapy.
- Benefits: Enjoy a full-time role with opportunities for collaboration and growth.
- Why this job: Make a real impact in cancer research while working with cutting-edge technology.
- Qualifications: PhD in relevant fields with 2-3 years of industry experience required.
- Other info: Ideal for those passionate about advancing therapeutic candidates towards clinical development.
The predicted salary is between 43200 - 72000 £ per year.
A pioneering biotech company at the forefront of cancer immunotherapy is seeking a Senior or Principal Scientist to join their dynamic team. This organization is focused on developing next-generation T-cell receptor (TCR)-based therapies to address solid tumors—areas historically difficult to treat with conventional immunotherapies.
Role Summary
The successful candidate will play a key role in driving the engineering, in vitro, and in vivo validation of TCR-based engagers. This includes hands-on work in molecular biology, protein science, and cell-based assays, as well as collaboration across multidisciplinary teams to advance therapeutic candidates toward clinical development.
Key Responsibilities
- Lead in vitro and in vivo validation of TCR-based T cell engagers.
- Design and characterize TCRs targeting proprietary and partnered disease indications.
- Execute protein science workflows, including expression, purification, and biophysical analyses of recombinant TCRs.
- Perform molecular biology tasks: cloning, mutagenesis, DNA isolation, and library prep for sequencing.
- Manage cell culture work, including media preparation, cell line maintenance, and cryopreservation.
- Contribute to the creation, revision, and maintenance of laboratory protocols and standard operating procedures (SOPs).
Required Qualifications
- PhD in Immunology, Cell Biology, Biochemistry, or related discipline, with 2-3 years of industry experience.
- Demonstrated experience with in vitro and in vivo validation of T cell engagers, ideally through to IND-enabling studies.
- Solid understanding of molecular biology techniques (e.g., cloning, PCR).
- Hands-on experience with protein expression, purification, and biophysical characterization.
- Experience with cell-based assays (e.g., flow cytometry, ELISA) is desirable.
- Familiarity with NGS library preparation and data analysis pipelines (e.g., using R) is a plus.
- Prior SOP development and documentation experience is advantageous.
Principal Scientist (Oxford) employer: Skills Alliance
Contact Detail:
Skills Alliance Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Principal Scientist (Oxford)
✨Tip Number 1
Make sure to highlight your hands-on experience with molecular biology techniques during any networking opportunities. Engaging with professionals in the field can help you gain insights and potentially get referrals.
✨Tip Number 2
Attend relevant biotech conferences or seminars where you can meet industry leaders and learn about the latest advancements in TCR-based therapies. This not only expands your knowledge but also helps you build valuable connections.
✨Tip Number 3
Join online forums or groups focused on cancer immunotherapy and biotechnology. Engaging in discussions can showcase your expertise and passion for the field, making you a more attractive candidate.
✨Tip Number 4
Consider reaching out to current or former employees of the company on LinkedIn. A brief chat can provide you with insider information about the company culture and expectations, which can be beneficial during interviews.
We think you need these skills to ace Principal Scientist (Oxford)
Some tips for your application 🫡
Match Your Skills: Before applying, carefully review the job description and ensure that your skills and experience align with the requirements. Highlight your relevant qualifications in your CV.
Tailor Your CV: Customise your CV to reflect the specific responsibilities and qualifications mentioned in the job listing. Emphasise your experience with TCR-based therapies, molecular biology techniques, and any relevant industry experience.
Craft a Compelling Cover Letter: Write a cover letter that showcases your passion for cancer immunotherapy and your understanding of the company's mission. Mention specific projects or experiences that demonstrate your expertise in the required areas.
Proofread Your Application: Before submitting, thoroughly proofread your CV and cover letter for any errors or typos. A polished application reflects your attention to detail and professionalism.
How to prepare for a job interview at Skills Alliance
✨Showcase Your Technical Expertise
Be prepared to discuss your hands-on experience with molecular biology techniques, protein science, and cell-based assays. Highlight specific projects where you successfully validated TCR-based therapies, as this will demonstrate your capability to contribute effectively to their team.
✨Demonstrate Collaborative Skills
Since the role involves working across multidisciplinary teams, share examples of how you've collaborated with others in previous roles. Emphasise your ability to communicate complex scientific concepts clearly and work towards common goals.
✨Prepare for Problem-Solving Questions
Expect questions that assess your problem-solving skills, particularly in relation to in vitro and in vivo validation processes. Think of challenges you've faced in past projects and how you overcame them, as this will showcase your critical thinking abilities.
✨Familiarise Yourself with Current Trends
Stay updated on the latest advancements in cancer immunotherapy and TCR-based therapies. Being knowledgeable about recent studies or breakthroughs can help you engage in meaningful discussions during the interview, showing your passion for the field.
