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- Tasks: Lead innovative research in cancer immunotherapy, focusing on TCR-based therapies.
- Company: Join a pioneering biotech company revolutionising cancer treatment with cutting-edge technology.
- Benefits: Enjoy a full-time role with opportunities for collaboration and professional growth.
- Why this job: Be part of a dynamic team making a real impact in the fight against cancer.
- Qualifications: PhD in Immunology or related field with 2-3 years of industry experience required.
- Other info: Experience with molecular biology and protein science is essential; familiarity with NGS is a plus.
The predicted salary is between 43200 - 72000 £ per year.
A pioneering biotech company at the forefront of cancer immunotherapy is seeking a Senior or Principal Scientist to join their dynamic team. This organization is focused on developing next-generation T-cell receptor (TCR)-based therapies to address solid tumors—areas historically difficult to treat with conventional immunotherapies. Role Summary The successful candidate will play a key role in driving the engineering, in vitro, and in vivo validation of TCR-based engagers. This includes hands-on work in molecular biology, protein science, and cell-based assays, as well as collaboration across multidisciplinary teams to advance therapeutic candidates toward clinical development. Key Responsibilities Lead in vitro and in vivo validation of TCR-based T cell engagers. Design and characterize TCRs targeting proprietary and partnered disease indications. Execute protein science workflows, including expression, purification, and biophysical analyses of recombinant TCRs. Perform molecular biology tasks: cloning, mutagenesis, DNA isolation, and library prep for sequencing. Manage cell culture work, including media preparation, cell line maintenance, and cryopreservation. Contribute to the creation, revision, and maintenance of laboratory protocols and standard operating procedures (SOPs). Required Qualifications ~ PhD in Immunology, Cell Biology, Biochemistry , or related discipline, with: ~2-3 years of industry experience. ~ Demonstrated experience with in vitro and in vivo validation of T cell engagers , ideally through to IND-enabling studies. ~ Solid understanding of molecular biology techniques (e.g., cloning, PCR). ~ Hands-on experience with protein expression, purification, and biophysical characterization . ~ Experience with cell-based assays (e.g., flow cytometry, ELISA) is desirable. ~ Familiarity with NGS library preparation and data analysis pipelines (e.g., using R) is a plus. ~ Prior SOP development and documentation experience is advantageous. Seniority level ~ Seniority level Mid-Senior level Employment type ~ Employment type Full-time Job function Job function Research and Science Industries Biotechnology Research and Pharmaceutical Manufacturing Referrals increase your chances of interviewing at Skills Alliance by 2x Get notified about new Principal Scientist jobs in Oxford, England, United Kingdom . Research Scientist, Surface Technologies Oxford, England, United Kingdom 1 day ago Oxford, England, United Kingdom 1 week ago Oxford, England, United Kingdom 1 week ago Oxford, England, United Kingdom 1 day ago Oxford, England, United Kingdom 1 week ago Oxford, England, United Kingdom 7 months ago Witney, England, United Kingdom 4 months ago Oxford, England, United Kingdom 1 week ago Principal Engineer or Scientist – Physical Modelling Oxford, England, United Kingdom 2 days ago Oxford, England, United Kingdom 1 week ago Research Scientist (Compound Coastal Hazards) Reading, England, United Kingdom 3 weeks ago Senior Engineer or Scientist – Physical Modelling Oxford, England, United Kingdom 1 week ago Senior Research Scientist, Computational Genomics at Oxford Research Site Oxford, England, United Kingdom 3 days ago Oxford, England, United Kingdom 2 days ago We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI. #J-18808-Ljbffr
Principal Scientist/Innovation Scientist employer: Skills Alliance
Contact Detail:
Skills Alliance Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Principal Scientist/Innovation Scientist
✨Tip Number 1
Network with professionals in the biotech field, especially those working in cancer immunotherapy. Attend industry conferences or webinars to connect with potential colleagues and learn about the latest advancements in TCR-based therapies.
✨Tip Number 2
Showcase your hands-on experience in molecular biology and protein science during informal discussions or networking events. Be prepared to discuss specific projects where you've successfully executed techniques like cloning, mutagenesis, or protein purification.
✨Tip Number 3
Familiarise yourself with the latest research and developments in T-cell receptor therapies. Being knowledgeable about current trends and challenges in the field will help you engage in meaningful conversations with hiring managers.
✨Tip Number 4
Consider reaching out to current or former employees of the company for informational interviews. This can provide you with valuable insights into the company culture and expectations, which can be beneficial during the interview process.
We think you need these skills to ace Principal Scientist/Innovation Scientist
Some tips for your application 🫡
Tailor Your CV: Make sure your CV highlights relevant experience in immunology, cell biology, and biochemistry. Emphasise any hands-on work with TCR-based therapies, molecular biology techniques, and protein science workflows.
Craft a Compelling Cover Letter: In your cover letter, express your passion for cancer immunotherapy and detail how your background aligns with the role's key responsibilities. Mention specific projects or experiences that demonstrate your expertise in in vitro and in vivo validation.
Highlight Collaborative Experience: Since the role involves collaboration across multidisciplinary teams, be sure to include examples of past teamwork in your application. Discuss how you contributed to successful projects and how you can bring that collaborative spirit to the new role.
Showcase Technical Skills: List your technical skills prominently, especially those related to molecular biology, protein expression, and cell-based assays. If you have experience with NGS library preparation or SOP development, make sure to highlight these as they are advantageous for the position.
How to prepare for a job interview at Skills Alliance
✨Showcase Your Technical Expertise
Be prepared to discuss your hands-on experience with molecular biology techniques, protein science workflows, and cell-based assays. Highlight specific projects where you successfully executed these tasks, as this will demonstrate your capability to contribute effectively to the team.
✨Demonstrate Collaborative Skills
Since the role involves working across multidisciplinary teams, share examples of how you've collaborated with others in previous roles. Emphasise your ability to communicate complex scientific concepts clearly and work towards common goals.
✨Prepare for Problem-Solving Questions
Expect questions that assess your problem-solving skills, particularly in relation to TCR-based therapies. Think of challenges you've faced in past projects and how you overcame them, as this will showcase your critical thinking and adaptability.
✨Familiarise Yourself with Current Trends
Stay updated on the latest advancements in cancer immunotherapy and T-cell receptor technologies. Being knowledgeable about current trends will not only impress your interviewers but also show your genuine interest in the field and the company's mission.
