About Serova
Serova builds personalized cancer vaccines. Each vaccine is made for the individual patient from their own samples and given in partnership with their treating physician. Knowing exactly what a patient's tumor and immune system look like, in depth, is what every vaccine starts from.
The role
We're building a small set of laboratory-developed tests (LDTs) with Azenta (GENEWIZ), made for cancer and cancer-vaccine patients. These aren't cheap, high-volume tests. They're built for depth: single-cell and long-read sequencing, 10,000x whole-exome from blood, and 100,000x large panels. You'll run that program with Azenta now, and plan how we bring the tests in-house once demand is there.
What you'll do
- Turn what our clinical and vaccine teams need into test specs: assay, depth, sample type and turnaround
- Own the day-to-day relationship with Azenta: scope, timelines, data handoffs, and holding them to quality and turnaround
- Write and run the development and validation plan for each LDT, from feasibility to clinical use
- Work with our bioinformatics team so the data comes back ready to analyze
- Work out the regulatory path for each test (CLIA/CAP, and FDA or UK rules where they apply) with our regulatory and quality leads
- Build the plan and business case for bringing the tests in-house
Who you are
- An assay development scientist turned project lead
- You've built and validated sequencing-based tests, not just run them
- You can talk to a partner lab as a technical equal
- You keep a multi-party program on one timeline
- High agency, friendly and low ego
Requirements
- Hands-on development or validation of a sequencing-based diagnostic assay (LDT, IVD or clinical research assay)
- A PhD in molecular biology, genomics or a related field, or equivalent industry experience
- Based in London or the San Francisco Bay Area, or willing to relocate
- Authorized to work in the UK or US, or a realistic path to get there
What will make you stand out
- You've taken an LDT through analytical validation in a CLIA/CAP lab
- Ultra-deep or low-input sequencing: liquid biopsy, ctDNA, deep panels, UMIs and error suppression
- Single-cell or long-read assays (10x, PacBio, Oxford Nanopore)
- You've managed a sequencing service or CRO partner, ideally Azenta/GENEWIZ
- Oncology or companion diagnostics background
- Some regulatory knowledge: CLIA, CAP, FDA rules on LDTs and IVDs, UK IVD rules
- You've set up or scaled an in-house sequencing lab
Details
- Location: London or San Francisco
- Type: Full-time
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