At a Glance
- Tasks: Join us in developing transformative therapies using cutting-edge cell line engineering and protein expression.
- Company: Scarlet Therapeutics, a pioneering biotech company in Bristol, UK.
- Benefits: Collaborative environment, career growth, and the chance to make a real impact in healthcare.
- Other info: Diverse and inclusive workplace committed to innovation and progress.
- Why this job: Be at the forefront of innovation in therapeutic red blood cells and contribute to groundbreaking research.
- Qualifications: PhD in relevant field and extensive experience in mammalian cell culture and protein expression.
The predicted salary is between 50000 - 70000 £ per year.
Scarlet Therapeutics is a biotechnology company developing transformative therapies. Building on more than a decade of world-renowned research in Bristol, UK, the team at Scarlet is pioneering unique technology to harness the potential of blood as medicine, positioning the company to become the global leader in the field of therapeutic red blood cells. We offer a fantastic working environment that is part of Science Creates, a Bristol-based deep tech ecosystem, combining specialist incubator facilities, a network of strategic partners and a dedicated venture capital fund.
We are seeking a highly skilled and motivated Senior Scientist to join our team with a proven track record of working with mammalian cell lines, including expressing protein and developing enzymatic assays in a whole cell environment or cellular background. The ideal candidate will have deep experience in growing and engineering cell lines, preferably red blood cells, and a strong track record of optimizing protein expression using lentiviral vectors.
Key Responsibilities:- Develop, culture, and maintain mammalian cell lines, with a preference for red blood cell or erythroid lineage systems
- Design, optimize, and implement lentiviral expression vectors to enhance protein expression
- Lead vector optimization strategies, including promoter selection, construct design, and transduction efficiency improvements
- Drive strategies to increase protein yield and stability in engineered cell lines
- Perform and analyze enzymatic assays to evaluate protein function and activity in a whole cell system
- Design and execute experiments independently, including data analysis and interpretation
- Document experimental results and contribute to reports, protocols, and internal presentations
- Collaborate with cross-functional teams to support research and development goals
- PhD or equivalent experience in Molecular Biology, Cell Biology, Biochemistry, Biotechnology, or a related field
- Minimum of 3 years' experience in mammalian cell culture and protein expression
- Extensive hands-on experience in cell line culture and protein expression
- Demonstrated expertise in lentiviral vector design, production, and transduction
- Proven experience optimizing protein expression levels in mammalian cells
- Experience with enzymatic assays and biochemical characterization techniques
- Strong experimental design, troubleshooting, and analytical skills
- Excellent communication and documentation skills
- Experience working with red blood cells or erythroid progenitor systems
- Background in gene therapy, synthetic biology, or advanced vector engineering
- Familiarity with scaling expression systems or translational research environments
Scarlet Therapeutics is proud to be an Equal Opportunity Employer, committed to fostering a diverse and inclusive work environment. We believe in the power of diverse perspectives to drive our innovation and progress. To qualify for this position, you will need to be authorized to live and work in the UK. In your application, please send a CV and a covering letter stating your motivations and what you think you could bring to the role.
Senior Scientist – Cell Line Engineering, Protein Expression & Assay Development employer: Scarlet Therapeutics Ltd
Scarlet Therapeutics is an exceptional employer, offering a dynamic and innovative work environment in the heart of Bristol's thriving deep tech ecosystem. With a strong commitment to employee growth and development, we provide unique opportunities for collaboration and advancement within the biotechnology field, all while fostering a diverse and inclusive culture that values every team member's contributions. Join us in pioneering transformative therapies and be part of a team that is shaping the future of medicine.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Scientist – Cell Line Engineering, Protein Expression & Assay Development
✨Tip Number 1
Network like a pro! Reach out to people in the industry, attend relevant events, and connect with Scarlet Therapeutics on LinkedIn. You never know who might have the inside scoop on job openings or can put in a good word for you.
✨Tip Number 2
Prepare for interviews by brushing up on your technical knowledge and being ready to discuss your past projects. We want to see how your experience aligns with the role, so be specific about your work with mammalian cell lines and protein expression.
✨Tip Number 3
Showcase your passion for the field! When you get the chance to chat with potential employers, let them know why you're excited about working with red blood cells and how you can contribute to their innovative therapies.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets seen by the right people. Plus, it shows you’re genuinely interested in joining our team at Scarlet Therapeutics.
We think you need these skills to ace Senior Scientist – Cell Line Engineering, Protein Expression & Assay Development
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to the Senior Scientist role. Highlight your experience with mammalian cell lines and protein expression, as well as any specific projects that align with what Scarlet Therapeutics is looking for.
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Share your motivations for applying and what unique skills you bring to the table. Be sure to mention your experience with lentiviral vectors and enzymatic assays, as these are key for the role.
Showcase Your Achievements:Don’t just list your responsibilities; showcase your achievements! Use specific examples of how you've optimised protein expression or developed successful cell lines. Numbers and results can really make your application stand out.
Apply Through Our Website:We encourage you to apply through our website for a smoother process. It’s the best way to ensure your application gets into the right hands and shows us you’re serious about joining our team at Scarlet Therapeutics!
How to prepare for a job interview at Scarlet Therapeutics Ltd
✨Know Your Science
Make sure you brush up on your knowledge of mammalian cell lines and protein expression. Be ready to discuss your hands-on experience with lentiviral vectors and how you've optimised protein yields in the past. This is your chance to showcase your expertise!
✨Prepare for Technical Questions
Expect some deep dives into your technical skills, especially around enzymatic assays and vector design. Practise explaining your experimental designs and troubleshooting methods clearly. The interviewers will want to see how you think on your feet!
✨Showcase Collaboration Skills
Scarlet Therapeutics values teamwork, so be prepared to talk about your experiences working with cross-functional teams. Share examples of how you've collaborated on projects and contributed to research goals. Highlighting your communication skills can set you apart!
✨Express Your Passion
Let your enthusiasm for biotechnology and therapeutic red blood cells shine through. Talk about what excites you about the role and how you align with the company's mission. A genuine passion can make a lasting impression on the interviewers!
