At a Glance
- Tasks: Develop and optimise mammalian cell lines for protein expression and enzymatic assays.
- Company: Join Scarlet Therapeutics, a pioneering biotech company in Bristol transforming blood into medicine.
- Benefits: Be part of a vibrant ecosystem with opportunities for growth and collaboration.
- Other info: Diverse and inclusive workplace committed to innovation and progress.
- Why this job: Make a real impact in biotechnology and contribute to groundbreaking therapies.
- Qualifications: PhD in relevant field and 3+ years in mammalian cell culture and protein expression.
The predicted salary is between 50000 - 70000 £ per year.
Scarlet Therapeutics is a biotechnology company developing transformative therapies. Building on more than a decade of world-renowned research in Bristol, UK, the team at Scarlet is pioneering unique technology to harness the potential of blood as medicine, positioning the company to become the global leader in the field of therapeutic red blood cells. We offer a fantastic working environment that is part of Science Creates, a Bristol-based deep tech ecosystem, combining specialist incubator facilities, a network of strategic partners and a dedicated venture capital fund.
We are seeking a highly skilled and motivated Senior Scientist to join our team with a proven track record of working with mammalian cell lines, including expressing protein and developing enzymatic assays in a whole cell environment or cellular background. The ideal candidate will have deep experience in growing and engineering cell lines, preferably red blood cells, and a strong track record of optimizing protein expression using lentiviral vectors.
Key Responsibilities:- Develop, culture, and maintain mammalian cell lines, with a preference for red blood cell or erythroid lineage systems
- Design, optimize, and implement lentiviral expression vectors to enhance protein expression
- Lead vector optimization strategies, including promoter selection, construct design, and transduction efficiency improvements
- Drive strategies to increase protein yield and stability in engineered cell lines
- Perform and analyze enzymatic assays to evaluate protein function and activity in a whole cell system
- Design and execute experiments independently, including data analysis and interpretation
- Document experimental results and contribute to reports, protocols, and internal presentations
- Collaborate with cross-functional teams to support research and development goals
- PhD or equivalent experience in Molecular Biology, Cell Biology, Biochemistry, Biotechnology, or a related field
- Minimum of 3 years' experience in mammalian cell culture and protein expression
- Extensive hands-on experience in cell line culture and protein expression
- Demonstrated expertise in lentiviral vector design, production, and transduction
- Proven experience optimizing protein expression levels in mammalian cells
- Experience with enzymatic assays and biochemical characterization techniques
- Strong experimental design, troubleshooting, and analytical skills
- Excellent communication and documentation skills
- Experience working with red blood cells or erythroid progenitor systems
- Background in gene therapy, synthetic biology, or advanced vector engineering
- Familiarity with scaling expression systems or translational research environments
Scarlet Therapeutics is proud to be an Equal Opportunity Employer, committed to fostering a diverse and inclusive work environment. We believe in the power of diverse perspectives to drive our innovation and progress.
To qualify for this position, you will need to be authorized to live and work in the UK. In your application, please send a CV and a covering letter stating your motivations and what you think you could bring to the role.
Senior Scientist – Cell Line Engineering, Protein Expression & Assay Development in Newport employer: Scarlet Therapeutics Ltd
Scarlet Therapeutics is an exceptional employer, offering a dynamic and collaborative work environment within the vibrant deep tech ecosystem of Bristol. Employees benefit from access to cutting-edge facilities, a strong network of strategic partners, and ample opportunities for professional growth in the rapidly evolving field of biotechnology. With a commitment to diversity and inclusion, Scarlet fosters a culture that values innovative thinking and encourages team members to contribute their unique perspectives towards transformative therapies.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Scientist – Cell Line Engineering, Protein Expression & Assay Development in Newport
✨Network Like a Pro
Get out there and connect with people in the industry! Attend conferences, workshops, or local meetups related to biotechnology. You never know who might have a lead on a job or can introduce you to someone at Scarlet Therapeutics.
✨Show Off Your Skills
When you get the chance to chat with potential employers, make sure to highlight your hands-on experience with mammalian cell lines and protein expression. Share specific examples of your work, especially if it relates to red blood cells or lentiviral vectors!
✨Follow Up
After any interview or networking event, don’t forget to send a quick thank-you email. It shows your enthusiasm for the role and keeps you fresh in their minds. Plus, it’s a great way to reiterate your interest in the Senior Scientist position.
✨Apply Through Our Website
Make sure to apply directly through the Scarlet Therapeutics website. It not only streamlines your application but also shows that you're genuinely interested in being part of their innovative team. Let’s get you that dream job!
We think you need these skills to ace Senior Scientist – Cell Line Engineering, Protein Expression & Assay Development in Newport
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to the Senior Scientist role. Highlight your experience with mammalian cell lines and protein expression, as well as any specific projects that relate to red blood cells or lentiviral vectors. We want to see how your skills align with what we're looking for!
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Share your motivations for applying and what excites you about working at Scarlet Therapeutics. Be sure to mention how your background makes you a great fit for our team. We love seeing genuine enthusiasm!
Showcase Your Achievements:When detailing your experience, focus on your achievements rather than just responsibilities. Use metrics where possible to demonstrate your impact, like improvements in protein yield or successful assay development. We appreciate candidates who can quantify their contributions!
Apply Through Our Website:We encourage you to apply through our website for a smoother application process. It helps us keep everything organised and ensures your application gets the attention it deserves. Plus, it’s super easy to do!
How to prepare for a job interview at Scarlet Therapeutics Ltd
✨Know Your Science
Make sure you brush up on your knowledge of mammalian cell lines, especially red blood cells. Be ready to discuss your previous experiences with protein expression and enzymatic assays in detail. This will show that you’re not just familiar with the concepts but have practical experience to back it up.
✨Showcase Your Problem-Solving Skills
Prepare to talk about specific challenges you've faced in your previous roles, particularly around vector optimization and protein yield. Highlight how you approached these problems and what strategies you implemented to overcome them. This will demonstrate your analytical skills and ability to troubleshoot effectively.
✨Collaborative Spirit
Scarlet Therapeutics values teamwork, so be ready to discuss how you've collaborated with cross-functional teams in the past. Share examples of how you contributed to research and development goals, and how you communicated complex scientific ideas to non-experts. This will show that you can work well within their environment.
✨Prepare Thoughtful Questions
At the end of the interview, you’ll likely have the chance to ask questions. Prepare some thoughtful ones about their current projects or future directions in therapeutic red blood cells. This shows your genuine interest in the company and the role, and it gives you a chance to assess if they’re the right fit for you too.
