At a Glance
- Tasks: Join us in developing transformative therapies using cutting-edge cell line engineering and protein expression.
- Company: Scarlet Therapeutics, a pioneering biotech company in Bristol, UK.
- Benefits: Collaborative work environment, opportunities for innovation, and career growth.
- Other info: Diverse and inclusive workplace committed to innovation.
- Why this job: Make a real impact in the field of therapeutic red blood cells.
- Qualifications: PhD in relevant field and experience with mammalian cell culture and protein expression.
The predicted salary is between 50000 - 70000 £ per year.
Scarlet Therapeutics is a biotechnology company developing transformative therapies. Building on more than a decade of world-renowned research in Bristol, UK, the team at Scarlet is pioneering unique technology to harness the potential of blood as medicine, positioning the company to become the global leader in the field of therapeutic red blood cells. We offer a fantastic working environment that is part of Science Creates, a Bristol-based deep tech ecosystem, combining specialist incubator facilities, a network of strategic partners and a dedicated venture capital fund.
We are seeking a highly skilled and motivated Senior Scientist to join our team with a proven track record of working with mammalian cell lines, including expressing protein and developing enzymatic assays in a whole cell environment or cellular background. The ideal candidate will have deep experience in growing and engineering cell lines, preferably red blood cells, and a strong track record of optimizing protein expression using lentiviral vectors.
Key Responsibilities:- Develop, culture, and maintain mammalian cell lines, with a preference for red blood cell or erythroid lineage systems
- Design, optimize, and implement lentiviral expression vectors to enhance protein expression
- Lead vector optimization strategies, including promoter selection, construct design, and transduction efficiency improvements
- Drive strategies to increase protein yield and stability in engineered cell lines
- Perform and analyze enzymatic assays to evaluate protein function and activity in a whole cell system
- Design and execute experiments independently, including data analysis and interpretation
- Document experimental results and contribute to reports, protocols, and internal presentations
- Collaborate with cross-functional teams to support research and development goals
- PhD or equivalent experience in Molecular Biology, Cell Biology, Biochemistry, Biotechnology, or a related field
- Minimum of 3 years' experience in mammalian cell culture and protein expression
- Extensive hands-on experience in cell line culture and protein expression
- Demonstrated expertise in lentiviral vector design, production, and transduction
- Proven experience optimizing protein expression levels in mammalian cells
- Experience with enzymatic assays and biochemical characterization techniques
- Strong experimental design, troubleshooting, and analytical skills
- Excellent communication and documentation skills
- Experience working with red blood cells or erythroid progenitor systems
- Background in gene therapy, synthetic biology, or advanced vector engineering
- Familiarity with scaling expression systems or translational research environments
Scarlet Therapeutics is proud to be an Equal Opportunity Employer, committed to fostering a diverse and inclusive work environment. We believe in the power of diverse perspectives to drive our innovation and progress.
To qualify for this position, you will need to be authorized to live and work in the UK. In your application, please send a CV and a covering letter stating your motivations and what you think you could bring to the role.
Senior Scientist – Cell Line Engineering, Protein Expression & Assay Development in Bristol employer: Scarlet Therapeutics Ltd
Scarlet Therapeutics is an exceptional employer, offering a dynamic and innovative work environment in the heart of Bristol's thriving deep tech ecosystem. With a strong commitment to employee growth and inclusivity, we provide opportunities for professional development while pioneering transformative therapies that harness the potential of blood as medicine. Join us to be part of a collaborative team dedicated to making a meaningful impact in biotechnology.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Scientist – Cell Line Engineering, Protein Expression & Assay Development in Bristol
✨Tip Number 1
Network like a pro! Reach out to people in the industry, attend relevant events, and connect with Scarlet Therapeutics on LinkedIn. You never know who might have the inside scoop on job openings or can put in a good word for you.
✨Tip Number 2
Prepare for interviews by brushing up on your technical skills and being ready to discuss your past projects. We recommend practising common interview questions related to cell line engineering and protein expression to show off your expertise.
✨Tip Number 3
Don’t just apply and wait! Follow up on your applications through our website. A quick email expressing your enthusiasm can make a big difference and shows that you're genuinely interested in joining the team.
✨Tip Number 4
Showcase your passion for the field! In interviews or networking situations, share your thoughts on the future of therapeutic red blood cells and how your experience aligns with Scarlet's mission. This will help you stand out as a candidate who truly cares.
We think you need these skills to ace Senior Scientist – Cell Line Engineering, Protein Expression & Assay Development in Bristol
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to the Senior Scientist role. Highlight your experience with mammalian cell lines and protein expression, as well as any specific projects that relate to the job description. We want to see how your skills align with what we're looking for!
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Share your motivations for applying and what excites you about working at Scarlet Therapeutics. Be sure to mention how your background in molecular biology or biochemistry makes you a great fit for our team.
Showcase Your Achievements:When detailing your experience, focus on your achievements rather than just responsibilities. Use metrics where possible to demonstrate your success in optimizing protein expression or developing assays. We love to see results!
Apply Through Our Website:Don't forget to apply through our website! It’s the best way for us to receive your application and ensures it gets into the right hands. Plus, it shows you're keen on joining our innovative team at Scarlet Therapeutics.
How to prepare for a job interview at Scarlet Therapeutics Ltd
✨Know Your Science
Make sure you brush up on your knowledge of mammalian cell lines and protein expression. Be ready to discuss your hands-on experience with lentiviral vectors and how you've optimised protein yields in the past. This is your chance to showcase your expertise!
✨Prepare for Technical Questions
Expect some deep dives into your technical skills, especially around enzymatic assays and vector design. Practise explaining your experimental designs and troubleshooting methods clearly. The interviewers will want to see how you think on your feet!
✨Showcase Your Collaboration Skills
Scarlet Therapeutics values teamwork, so be prepared to talk about your experiences working with cross-functional teams. Share specific examples of how you’ve collaborated on projects and contributed to research goals. Highlighting your communication skills can set you apart!
✨Express Your Passion for Innovation
Demonstrate your enthusiasm for the field of biotechnology and how it aligns with Scarlet's mission. Talk about any innovative projects you've been involved in or ideas you have for future research. Showing that you're forward-thinking can really impress the interviewers!
