At a Glance
- Tasks: Develop and optimise mammalian cell lines for protein expression and enzymatic assays.
- Company: Join Scarlet Therapeutics, a pioneering biotech company in Bristol transforming blood into medicine.
- Benefits: Collaborative environment with opportunities for professional growth and innovation.
- Other info: Diverse and inclusive workplace committed to innovation and progress.
- Why this job: Make a real impact in biotechnology and contribute to groundbreaking therapies.
- Qualifications: PhD in relevant field and 3+ years of experience in cell culture and protein expression.
The predicted salary is between 50000 - 70000 £ per year.
Scarlet Therapeutics is a biotechnology company developing transformative therapies. Building on more than a decade of world-renowned research in Bristol, UK, the team at Scarlet is pioneering unique technology to harness the potential of blood as medicine, positioning the company to become the global leader in the field of therapeutic red blood cells. We offer a fantastic working environment that is part of Science Creates, a Bristol-based deep tech ecosystem, combining specialist incubator facilities, a network of strategic partners and a dedicated venture capital fund.
We are seeking a highly skilled and motivated Senior Scientist to join our team with a proven track record of working with mammalian cell lines, including expressing protein and developing enzymatic assays in a whole cell environment or cellular background. The ideal candidate will have deep experience in growing and engineering cell lines, preferably red blood cells, and a strong track record of optimizing protein expression using lentiviral vectors.
Key Responsibilities:- Develop, culture, and maintain mammalian cell lines, with a preference for red blood cell or erythroid lineage systems
- Design, optimize, and implement lentiviral expression vectors to enhance protein expression
- Lead vector optimization strategies, including promoter selection, construct design, and transduction efficiency improvements
- Drive strategies to increase protein yield and stability in engineered cell lines
- Perform and analyze enzymatic assays to evaluate protein function and activity in a whole cell system
- Design and execute experiments independently, including data analysis and interpretation
- Document experimental results and contribute to reports, protocols, and internal presentations
- Collaborate with cross-functional teams to support research and development goals
- PhD or equivalent experience in Molecular Biology, Cell Biology, Biochemistry, Biotechnology, or a related field
- Minimum of 3 years' experience in mammalian cell culture and protein expression
- Extensive hands-on experience in cell line culture and protein expression
- Demonstrated expertise in lentiviral vector design, production, and transduction
- Proven experience optimizing protein expression levels in mammalian cells
- Experience with enzymatic assays and biochemical characterization techniques
- Strong experimental design, troubleshooting, and analytical skills
- Excellent communication and documentation skills
- Experience working with red blood cells or erythroid progenitor systems
- Background in gene therapy, synthetic biology, or advanced vector engineering
- Familiarity with scaling expression systems or translational research environments
Scarlet Therapeutics is proud to be an Equal Opportunity Employer, committed to fostering a diverse and inclusive work environment. We believe in the power of diverse perspectives to drive our innovation and progress.
To qualify for this position, you will need to be authorized to live and work in the UK. In your application, please send a CV and a covering letter stating your motivations and what you think you could bring to the role.
Senior Scientist – Cell Line Engineering, Protein Expression & Assay Development in Bath employer: Scarlet Therapeutics Ltd
Scarlet Therapeutics is an exceptional employer, offering a dynamic and innovative work environment in the heart of Bristol's thriving deep tech ecosystem. With a strong commitment to employee growth and diversity, we provide unique opportunities for professional development while pioneering transformative therapies that harness the potential of blood as medicine. Join us to be part of a collaborative team dedicated to making a meaningful impact in biotechnology.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Scientist – Cell Line Engineering, Protein Expression & Assay Development in Bath
✨Tip Number 1
Network like a pro! Reach out to people in the industry, attend relevant events, and connect with Scarlet Therapeutics on LinkedIn. You never know who might have the inside scoop on job openings or can put in a good word for you.
✨Tip Number 2
Prepare for interviews by brushing up on your technical skills and being ready to discuss your past projects. Make sure you can explain how your experience with mammalian cell lines and protein expression aligns with what Scarlet is looking for.
✨Tip Number 3
Show your passion for the field! When you get the chance to chat with someone from Scarlet, share your excitement about their work with red blood cells and how you can contribute to their mission. Enthusiasm goes a long way!
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets seen. Plus, it shows you’re serious about joining the team at Scarlet Therapeutics.
We think you need these skills to ace Senior Scientist – Cell Line Engineering, Protein Expression & Assay Development in Bath
Some tips for your application 🫡
Tailor Your CV:Make sure your CV highlights your experience with mammalian cell lines and protein expression. We want to see how your skills align with the role, so don’t be shy about showcasing your relevant achievements!
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Tell us why you’re excited about the position and how your background makes you the perfect fit. We love hearing about your motivations and what you can bring to our team.
Be Clear and Concise:When writing your application, keep it clear and to the point. We appreciate well-structured documents that are easy to read. Avoid jargon unless it’s relevant to the role – we want to understand your expertise without getting lost in technical terms!
Apply Through Our Website:Don’t forget to submit your application through our website! It’s the best way for us to receive your materials and ensures you’re considered for the role. Plus, it helps us keep everything organised!
How to prepare for a job interview at Scarlet Therapeutics Ltd
✨Know Your Science
Make sure you brush up on your knowledge of mammalian cell lines and protein expression. Be ready to discuss your hands-on experience with lentiviral vectors and how you've optimised protein yields in the past. This is your chance to showcase your expertise!
✨Prepare for Technical Questions
Expect some deep dives into your technical skills, especially around enzymatic assays and vector design. Practise explaining your experimental designs and troubleshooting methods clearly. The interviewers will want to see how you think on your feet!
✨Showcase Collaboration Skills
Scarlet Therapeutics values teamwork, so be prepared to discuss how you've collaborated with cross-functional teams in previous roles. Share specific examples of how your contributions have supported research and development goals.
✨Express Your Passion
Let your enthusiasm for the field shine through! Talk about why you're excited about the potential of blood as medicine and how your background aligns with their mission. A genuine passion can set you apart from other candidates.
