At a Glance
- Tasks: Develop and optimise innovative drug products using advanced modelling techniques.
- Company: Join a leading biopharmaceutical company focused on impactful drug development.
- Benefits: Comprehensive healthcare, retirement savings, and employee discounts.
- Other info: Collaborative environment with opportunities for innovation and career growth.
- Why this job: Make a real difference in patient outcomes through cutting-edge science.
- Qualifications: PhD or MSc in relevant scientific fields with strong modelling expertise.
The predicted salary is between 42750 - 52250 £ per year.
We are seeking a highly motivated Senior Scientist with expertise in Physiologically Based Pharmacokinetic (PBPK) and Physiologically Based Biopharmaceutics Modelling (PBBM) to support the development and optimization of innovative drug products across all stages of development.
The successful candidate will apply mechanistic modelling and simulation approaches to understand and predict the impact of drug substance properties, formulation design, dissolution, physiology, and clinical variables on in vivo performance and patient outcomes. The scientist will work within multidisciplinary project teams and collaborate closely with scientists in biopharmaceutics, formulation development, clinical pharmacology and PDM (Pharmacokinetics, Distribution and Metabolism) to support model-informed drug development and regulatory decision-making.
Key Responsibilities
- Develop, verify, and apply PBBM and PBPK models using platforms such as Simcyp, GastroPlus or equivalent software.
- Support the prediction and assessment of oral absorption, food effect, bioavailability, formulation bridging, dissolution and particle size specifications, and virtual bioequivalence.
- Perform model calibration, sensitivity analyses, scenario testing, and uncertainty assessments to support project decisions.
- Collaborate with laboratory scientists to design and interpret in vitro studies supporting model development and verification.
- Support the development of clinically relevant dissolution methods and in vitro-in vivo links where appropriate.
- Communicate modelling outcomes through technical reports, project team presentations, regulatory documents, and scientific publications.
- Contribute to innovation in modelling methodologies, automation, and data-driven approaches, including AI/ML-enabled predictive tools where appropriate.
Required Qualifications
- PhD or MSc in Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics, Pharmacometrics, Chemical Engineering or a related scientific discipline. For MSc candidates, substantial relevant industrial experience in PBPK, PBBM, pharmacometrics, mechanistic modelling or model-informed drug development is required.
- Demonstrated expertise in PBPK, PBBM, pharmacometrics, mechanistic modelling, or model-informed drug development.
- Strong understanding of oral absorption, dissolution, permeability, biopharmaceutics, and pharmacokinetics.
- Experience with PBPK/PBBM modelling software such as Simcyp, GastroPlus, PK-Sim or similar platforms.
- Demonstrated ability to apply modelling to solve pharmaceutical development challenges.
- Strong written and verbal scientific communication skills.
- Evidence of scientific productivity through publications, presentations, technical reports or regulatory contributions.
Preferred Qualifications
- Experience supporting regulatory submissions involving PBPK or PBBM analyses.
- Experience with virtual bioequivalence or clinically relevant dissolution specifications.
- Working knowledge of Python, R, MATLAB, or other scientific programming tools.
- Experience applying machine learning or data science approaches to pharmaceutical development.
- Experience across multiple drug modalities, including poorly soluble compounds, enabling formulations, peptides, or complex dosage forms.
Senior Scientist, Biopharmaceutics Modelling & Simulation employer: Russell Tobin
As a Senior Kotlin Engineer at our client, you will join a dynamic and inclusive work culture that prioritises employee well-being and professional growth. Located in a vibrant area, the company offers comprehensive benefits including healthcare coverage, retirement savings plans, and unique perks like pet insurance and legal support, ensuring a rewarding work-life balance. With a commitment to equal opportunity and fair chance employment, this is an excellent place for talented individuals seeking meaningful and impactful careers.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Scientist, Biopharmaceutics Modelling & Simulation
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We think you need these skills to ace Senior Scientist, Biopharmaceutics Modelling & Simulation
Some tips for your application 🫡
Showcase Your Relevant Experience:When applying for a role in the pharmaceutical industry, it's crucial to highlight any relevant experience you have. Whether that's internships, lab work, or even related coursework, make sure to weave this into your CV and cover letter. We want to see how your background aligns with the role you're applying for at Russell Tobin!
Emphasise Your Understanding of Regulations:The pharmaceutical industry is heavily regulated, so it's important to indicate your familiarity with industry standards and regulations. In your cover letter, mention any training or certifications you've received that are relevant, or discuss projects where you’ve navigated compliance. This will show Russell Tobin that you're not just a fit for the job but also a safety-conscious candidate!
Tailor Your CV to Be Result-Driven:Craft your CV to highlight quantifiable achievements, especially if you have previous roles in pharmaceuticals or related fields. Use metrics to demonstrate your impact, such as improved processing times or successful project completions while working on trials. This analytical approach will resonate well with hiring managers at Russell Tobin!
Convey Your Passion for the Industry:In your cover letter, express why you are passionate about working in the pharmaceutical sector. Whether it’s your desire to contribute to groundbreaking drug research or improve patient outcomes, let it shine through! At Russell Tobin, we value candidates who are truly enthusiastic about their work—you might just stand out from the crowd.
How to prepare for a job interview at Russell Tobin
✨Understand the Science
Make sure you brush up on key pharmaceutical concepts and recent developments in the industry. You might get asked some technical questions during the interview at Russell Tobin that show your grasp of drug development processes or regulatory requirements, so be ready to discuss them clearly.
✨Showcase Relevant Experience
If you have any hands-on experience or internships in a laboratory setting, be sure to highlight these in your responses. Think about the projects you worked on, the methodologies you used, and the impact you made. It's all about telling a story that connects your background to the role you're applying for.
✨Know Their Products
Take some time to familiarise yourself with Russell Tobin’s product range and recent breakthroughs. Understanding their portfolio not only shows your enthusiasm for the role but also allows you to ask insightful questions that demonstrate your interest in actively contributing to their projects.
✨Be Ready for Regulatory Scenarios
In a full-time pharmaceutical role, understanding the regulatory landscape is crucial. Prepare for situational questions that may test your problem-solving skills concerning compliance and safety standards. You could be asked how you'd handle a hypothetical issue regarding a drug’s market release, so think through your approach.
