This role is a permanent position based in the Process Development Group in Deeside (North Wales). As a Process Development Scientist - Bio-conjugation, you will work across all stages from early research (non-GMP) through to full development of processes for clinical trials manufacture (cGMP regulated). The position is laboratory based, and you will spend 80% of your time in the laboratory and 20% in the office. You will need to work accurately, to high quality standards and to tight timelines. You will work in a fast-paced environment and will have direct client contact. This requires clear communication of complex data sets via written and oral presentations as a regular requirement. Responsibilities: Develop methods for and perform the conjugation of small molecules (e.g. cytotoxins and chelators) and polymers to antibodies and proteins using a number of chemical and enzymatic conjugation techniques. Characterise manufactured antibody and protein conjugates using HPLC and mass spectrometry. To perform broader process robustness, characterisation and optimisation studies. To support with process scale-up and ultimately transfer into manufacturing facilities. Support with formulation development and stability studies as required. Comply with all safety, health, and environmental requirements. Presenting data to clients and internal scientific teams. Keeping accurate records and document experimental results in laboratory notebooks. Planning you own work to meet project objectives in a timely manner. Taking part in laboratory housekeeping and contributing to general maintenance of laboratory equipment. Performing tasks accurately following protocols (standard operating procedures (SOPs) and risk assessments). Requirements for the role: Minimum BSc in Biochemistry, Biotechnology, Natural Sciences, Chemistry or related Science discipline plus a minimum of 2-3 years relevant experience in at least one of the following areas: Protein conjugation / modification. Protein downstream purification – chromatography and TFF. Protein physicochemical analysis – specifically HPLC and Mass Spectrometry. Experience of working under Good Manufacturing Practices (cGMP / GMP) (Desirable). Must be a team player with proven experience of working within a high performing team. Scientific mindset with problem solving skills and have the drive to see issues to a successful resolution. Excellent communication skills, organisational skills and with a good eye for detail Must align to our company values; Be Transparent, Be Willing, Be Reliable and Be Caring The ideal candidate would be someone who enjoys rising to new challenges and who holds a positive can-do attitude. Support and training will be provided to upskill the successful candidates. This is an excellent opportunity to gain and build upon knowledge and experience in a rapidly growing and innovative field.
Process Development Scientist - Bio-Conjugation employer: RRxCo.
At RRxCo, we pride ourselves on being an exceptional employer in the life sciences sector, offering fully remote working opportunities that allow you to connect with a global client base. Our commitment to employee growth is evident through our annual bonus scheme, achievement awards, and regular recognition initiatives, all within a collaborative and innovative work culture that challenges industry norms. Join us to be part of a dynamic team where your contributions are valued and rewarded, and where you can shape the future of life science consultancy.
