At a Glance
- Tasks: Lead innovative projects in bioconjugation and scale-up processes for drug development.
- Company: Established CDMO with over 50 years of expertise in the industry.
- Benefits: Competitive salary, professional growth opportunities, and a collaborative work environment.
- Other info: Join a dynamic team focused on cutting-edge bioconjugation technologies.
- Why this job: Make a real impact in drug development and contribute to life-changing therapies.
- Qualifications: PhD in Chemistry or related field with 10+ years of industry experience.
The predicted salary is between 70000 - 90000 € per year.
We are leading the search for a Principal Scientist to join the Process Development team on behalf of our client, an established CDMO with over 50 years' expertise. The bioconjugation scientists play a critical role in bridging the gap between small-molecule chemistry and large-molecule biologics, primarily focusing on the development and scale-up of Antibody-Drug Conjugates (ADCs) and other bioconjugates. You will execute and manage the delivery of projects supporting our clients early-stage research and then progress lead candidate into clinical-scale manufacturing, ensuring high-quality drug candidates are ready for the clinic.
Process Design & Optimisation: Independently design and execute experiments to develop scalable bioconjugation and purification processes.
Scale-up & Tech Transfer: Transitioning processes from bench-top research to larger-scale production while maintaining product quality.
Downstream Processing: Optimise purification workflows using ÄKTA chromatography systems and Tangential Flow Filtration (TFF).
Analytical Characterisation: Perform in-depth product analysis using HIC, SEC, IEX, and LC-MS to ensure quality, purity and stability.
Data-Driven Innovation: Apply Quality by Design (QbD) and Design of Experiments (DoE) principles to identify critical process parameters.
Collaboration: Work cross-functionally with Project Management, Process Introduction, Analytical, and Quality teams during process development and transfer into clinical manufacturing.
To be successful you will hold:
- BSc/MSc/PhD in Chemistry, Biochemistry, or Chemical Biology; and with at least 10 years relevant industry experience.
- An in-depth understanding of, and proven hands-on experience with the conjugation of small molecules (cytotoxins, fluorochromes, chelators, oligonucleotides etc) to antibodies (and other proteins).
- Be skilled in all aspects of downstream process development, including reactive chemistry.
- Experience working with highly potent molecules and associated containment strategies is advantageous.
- Knowledge of cGMP and EU, MHRA and FDA regulations.
- Proficiency in interpreting complex data using software such as Chemstation, Chromeleon, ChemDraw.
- Experience in high throughput / parallel process & reaction screening.
- Process optimisation and validation for late phase / commercial.
Principal Scientist - Process Development in Deeside employer: RRxCo.
Join a pioneering CDMO with over 50 years of expertise, where your role as a Principal Scientist in Process Development will be pivotal in advancing innovative bioconjugate therapies. Our collaborative work culture fosters creativity and professional growth, offering you the chance to lead impactful projects while benefiting from comprehensive training and development opportunities. Located in a vibrant area, we provide a supportive environment that values quality, innovation, and employee well-being, making us an exceptional employer for those seeking meaningful contributions in the biopharmaceutical industry.
StudySmarter Expert Advice🤫
We think this is how you could land Principal Scientist - Process Development in Deeside
✨Tip Number 1
Network like a pro! Reach out to your connections in the industry, attend relevant events, and engage with professionals on platforms like LinkedIn. We can’t stress enough how important it is to make those personal connections that could lead to job opportunities.
✨Tip Number 2
Prepare for interviews by practising common questions and showcasing your expertise in bioconjugation and process development. We recommend doing mock interviews with friends or mentors to boost your confidence and refine your answers.
✨Tip Number 3
Showcase your projects! Create a portfolio or presentation that highlights your past work in process design and optimisation. This will help you stand out and demonstrate your hands-on experience to potential employers.
✨Tip Number 4
Don’t forget to apply through our website! We’ve got a range of exciting opportunities waiting for you, and applying directly can sometimes give you an edge. Plus, it’s super easy to navigate!
We think you need these skills to ace Principal Scientist - Process Development in Deeside
Some tips for your application 🫡
Tailor Your CV:Make sure your CV is tailored to the Principal Scientist role. Highlight your experience in bioconjugation and process development, and don’t forget to mention any relevant projects you've worked on that align with our client's needs.
Craft a Compelling Cover Letter:Your cover letter is your chance to shine! Use it to explain why you're the perfect fit for this role. Share specific examples of your work with ADCs and how you’ve successfully transitioned processes from research to clinical-scale manufacturing.
Showcase Your Technical Skills:We want to see your technical prowess! Be sure to include your experience with downstream processing techniques like chromatography and TFF, as well as your familiarity with data analysis software. This will help us understand your hands-on capabilities.
Apply Through Our Website:Don’t forget to apply through our website! It’s the best way for us to receive your application and ensures you’re considered for the role. Plus, it makes the whole process smoother for everyone involved.
How to prepare for a job interview at RRxCo.
✨Know Your Science
Make sure you brush up on your knowledge of bioconjugation and ADCs. Be ready to discuss your hands-on experience with small molecules and antibodies, as well as any relevant projects you've worked on. This will show that you not only understand the theory but can also apply it practically.
✨Showcase Your Problem-Solving Skills
Prepare to share specific examples of how you've tackled challenges in process development or optimisation. Think about times when you had to transition processes from bench-top to larger-scale production and how you ensured quality throughout. This will demonstrate your ability to think critically and adapt.
✨Familiarise Yourself with Regulations
Since knowledge of cGMP and regulatory standards is crucial, make sure you're up to speed on EU, MHRA, and FDA regulations. Being able to discuss how you've navigated these in past roles will set you apart and show that you take compliance seriously.
✨Collaborate and Communicate
Highlight your experience working cross-functionally with different teams. Prepare to discuss how you've collaborated with project management, analytical, and quality teams during process development. Strong communication skills are key, so be ready to demonstrate how you can effectively work with others to achieve common goals.
