This role is a permanent position based in the Process Development Group in Deeside (North Wales). As a Process Development Scientist - Bio-conjugation, you will work across all stages from early research (non-GMP) through to full development of processes for clinical trials manufacture (cGMP regulated).
The position is laboratory based, and you will spend 80% of your time in the laboratory and 20% in the office. You will need to work accurately, to high quality standards and to tight timelines. You will work in a fast-paced environment and will have direct client contact. This requires clear communication of complex data sets via written and oral presentations as a regular requirement.
Responsibilities:
- Develop methods for and perform the conjugation of small molecules (e.g. cytotoxins and chelators) and polymers to antibodies and proteins using a number of chemical and enzymatic conjugation techniques.
- Characterise manufactured antibody and protein conjugates using HPLC and mass spectrometry.
- To perform broader process robustness, characterisation and optimisation studies.
- To support with process scale-up and ultimately transfer into manufacturing facilities.
- Support with formulation development and stability studies as required.
- Comply with all safety, health, and environmental requirements.
- Presenting data to clients and internal scientific teams.
- Keeping accurate records and document experimental results in laboratory notebooks.
- Planning you own work to meet project objectives in a timely manner.
- Taking part in laboratory housekeeping and contributing to general maintenance of laboratory equipment.
- Performing tasks accurately following protocols (standard operating procedures (SOPs) and risk assessments).
Requirements for the role:
- Minimum BSc in Biochemistry, Biotechnology, Natural Sciences, Chemistry or related Science discipline plus a minimum of 2-3 years relevant experience in at least one of the following areas:
- Protein conjugation / modification.
- Protein downstream purification – chromatography and TFF.
- Protein physicochemical analysis – specifically HPLC and Mass Spectrometry.
- Experience of working under Good Manufacturing Practices (cGMP / GMP) (Desirable).
- Must be a team player with proven experience of working within a high performing team.
- Scientific mindset with problem solving skills and have the drive to see issues to a successful resolution.
- Excellent communication skills, organisational skills and with a good eye for detail
- Must align to our company values; Be Transparent, Be Willing, Be Reliable and Be Caring
The ideal candidate would be someone who enjoys rising to new challenges and who holds a positive can-do attitude. Support and training will be provided to upskill the successful candidates.
This is an excellent opportunity to gain and build upon knowledge and experience in a rapidly growing and innovative field.
Process Development Scientist - Bio-Conjugation in Deeside employer: RRxCo.TM
Join a leading CRO that values expertise and innovation, offering a dynamic work culture where your contributions directly impact quality assurance in the pharma and biotech sectors. With a focus on employee growth, you will have access to professional development opportunities while working remotely from the UK, ensuring a flexible work-life balance during this critical period. This role not only allows you to lead in a pivotal time but also to collaborate with cross-functional teams, enhancing your leadership skills in a supportive environment.
