Research Physician - RWE/Epidemiology in London

Location: London Bridge, SE1

Term: Full-Time, Permanent

Salary: Competitive + Benefits (Private Medical, Private Dental, Pension, 25 days Annual leave plus bank holidays & Many more)

Richmond Pharmacology are an early phase Clinical Research Organisation (CRO), where we are conducting pioneering early phase healthy participants and patient participant trials. Our experienced and world-renowned team, our central London location and our global reach contribute to making Richmond Pharmacology an exciting and dynamic place to work.

Purpose of the job

This is an excellent opportunity for a clinically trained physician to combine medical expertise with real-world evidence (RWE) science in a dynamic, growing team. Reporting directly to the Medical Director, you will be responsible for the day-to-day scientific and clinical delivery of observational studies, patient registries, and AI-assisted data insights that generate evidence for our clients.

You will work closely with the Medical Director on study design, taking ownership of delivery, documentation, and stakeholder coordination across projects. The primary focus of the role is non-interventional research and registry work, with a smaller proportion of time supporting interventional clinical trials as needed. This is a hands-on scientific role with clear scope to develop your expertise in RWE methodology, health data science, and evidence generation.

Main duties and responsibilities

• Study Design & Oversight
• Provide clinical input in the design of real-world evidence studies, including retrospective cohort studies, case-control studies, database studies, patient registries, and longitudinal observational cohorts.
• Ensure sufficient patients to support the objectives of all NIS studies.
• Provide medical support for non-interventional studies, ensuring compliance with UK regulations, ICH-GCP (where applicable) and GDPR.
• Oversee medical components of AI-assisted studies, AI-assisted data lake searches, model validation, algorithmic bias review, and clinical input into machine learning outputs.
• Be the main liaison to the Principal Investigator; in consultation with PI make decisions to include/reject participants based on protocols, eligibility criteria, clinical practice, unit guidelines. Escalate complex issues to the Medical Director/PI as needed.
• Collaborate in planning and design of screening activities with other departments to achieve study timelines – e.g. Patient Engagement Team and Recruitment.
• Interventional Trial Support
• Providing medical oversight and clinical input on assigned interventional studies, working alongside the Principal Investigator, project management, clinical operations team volunteer recruitment and patient engagement teams to support trial delivery.
• Contributing to protocol review, eligibility assessments, and medical monitoring activities.
• Supporting the preparation of trial documentation including clinical sections of protocols, investigator brochures, and safety reports.
• Ensuring compliance with ICH-GCP, applicable regulations, and sponsor requirements for any assigned interventional work.
• Epidemiological & Analytical Contributions
• Provide support for the creation and clinical interpretation of epidemiological data outputs, including incidence, prevalence, risk factor modelling, and survival analyses.
• Guide the development of disease definitions, cohort selection algorithms, and clinical phenotypes for use in large datasets.
• Review and approve data handling plans (DHPs) and statistical analysis plans (SAPs) from a clinical perspective to ensure scientific rigor and relevance.
• Medical Writing & Regulatory
• Contribute to or review scientific documents such as study protocols, statistical analysis plans (SAPs), SOM sections for GLSO, PIS/ICF sections, Clinical Study Reports (CSRs) and RWE publications, regulatory submissions, and Medical Review Summaries.
• Attend REC meetings and present study applications under the direction of the Medical Director.
• Support dissemination of findings through white papers, presentations, and peer-reviewed publications.
• Take ownership of SOPs/WIs and be responsible for maintaining their status and updates.
• Prepare presentations for prospective sponsors on study proposals e.g., bid defence.

Skills and Experience:

• Medical Degree (MBBS, MBChB, MD, or equivalent)
• Full GMC Registration
• Postgraduate Clinical Training
• Postgraduate Qualification in Epidemiology, Public Health, or Clinical Research (Desirable)
• Training in Real-World Evidence (RWE) Methodologies (Desirable)
• Good understanding of internal and external real-world data sources (private and public).
• Comfortable interpreting and critically evaluating biostatistical results and methodologies.

Application:

If you are interested in the role, please register your details, including a copy of your CV. Please note, while we try to respond to every candidate, the high volume of applications anticipated may make this impossible and we ask for your patience and understanding.