Senior Scientist - Multicellular Disease Models – Target Validation

Relation is an end-to-end biotech developing transformational medicines, with technology at our core. Our ambition is to understand human biology in unprecedented ways, discovering therapies to treat some of life’s most devastating diseases. We leverage single-cell multi-omics directly from patient tissue, functional assays, and machine learning to drive disease understanding, from cause to cure. This year, we’ve embarked on an exciting double collaboration with GSK to tackle fibrosis and osteoarthritis, alongside advancing our own internal osteoporosis programme. By combining our cutting-edge ML capabilities with their deep expertise in drug discovery, this partnership underscores our commitment to pioneering science and delivering impactful therapies to patients.

We are rapidly scaling our technology and discovery teams, offering a unique opportunity to join one of the most innovative Biotech companies. Be part of our dynamic, interdisciplinary teams, collaborating closely to redefine the boundaries of possibility in drug discovery. Our state-of-the-art wet and dry laboratories, located in the heart of London, provide an exceptional environment to foster interdisciplinarity and turn groundbreaking ideas into positive impact for patients. We are committed to building diverse and inclusive teams. Relation is an equal opportunities employer and does not discriminate on the grounds of gender, sexual orientation, marital or civil partner status, gender reassignment, race, colour, nationality, ethnic or national origin, religion or belief, disability, or age. We cultivate innovation through collaboration, empowering every team member to do their best work and develop to their highest potential. By joining Relation, you will be part of an exceptionally talented team, with extraordinary leverage to advance the field of drug discovery. Your work will shape our culture, strategic direction, and, most importantly, impact patients’ lives.

We have an exciting opportunity for a Senior Scientist - Multicellular Disease Models to join Relation’s cutting-edge experimental laboratory and contribute to our drug discovery initiatives. The successful candidate will be responsible for the development of disease relevant multicellular models with multi-parametric endpoints, supporting and executing target validation experiments, generating and interpreting scientific data, and supporting the maintenance of the laboratory. Your contributions will be part of advancing our research and ensuring successful project outcomes. As part of the Relation team, you will join a team of talented professionals, including wet-lab scientists and data scientists and gain exposure to a diverse range of skills, both in and outside of your primary area of expertise. You will have the opportunity to contribute to the development of our positive and inclusive organisational culture and ultimately, make a positive impact on patients' lives.

Your responsibilities:

• Work within the team to design, optimise and establish 3D multicellular and other complex cellular models that closely mimic human tissue architecture and disease states to permit the interrogation of novel target biology.
• Contribute intellectually and experimentally to the design and timely execution of all elements of mechanism of action studies by applying cellular and molecular biology techniques.
• Proficient in cellular and molecular biology to contribute to projects focused on understanding novel target biology.
• Generate, analyse & contribute biological data to Relation's novel drug discovery projects.
• Work as a member of the lab team to ensure efficient running of the lab, including a variety of responsibilities as required.

Professionally, you have:

• A PhD and at least 3-5 years additional experience with an outstanding track record in biotech, pharma or academia with demonstrable experience in assay development and/or target validation.
• Immunology expertise, as evidenced by publication in high impact journals.
• Experience with a variety of mammalian cellular models including established cell lines, patient-derived primary cells and the development of 2D or 3D multicellular assays, with functional disease relevant endpoints with the aim of ensuring required reproducibility and sensitivity in those assays.
• Experience using multi-parameter endpoints including, but not limited to flow cytometry, fluorescence microscopy, plate based fluorescent assays, soluble ligand analysis, RT-qPCR.
• Knowledge of gene editing tools (e.g., CRISPR/Cas9) and RNA interference for modulating gene expression in 2D and 3D cell systems.
• A proven ability to work closely within cross-functional teams to progress target validation projects and present findings to internal stakeholders.

Desirable knowledge or experiences:

• Previous Pharma or Biotech experience is desirable.
• Comfortable working in a Biotech environment.
• Familiarity with electronic lab notebook systems & SOPs.

Personally, you are:

• A collaborative team player.
• A clear and effective communicator.
• Driven by the impact of preclinical development.
• Motivated to stay at the forefront of scientific advancements.
• Passionate about contributing to meaningful advancements in healthcare.

Join us in this exciting role where your contributions will have a direct impact on advancing our understanding of genetics and disease risk, supporting our mission to get transformative medicines to patients. Together, we're not just doing research; we're setting new standards in the field of machine learning and genetics. The patient is waiting!