Senior Clinical Pharmacologist in Cambridge

As a Senior Clinical Pharmacologist, this individual is expected to plan, design, implement and analyze in‑vivo and in‑vitro pharmacokinetic & pharmacodynamic studies working with Clinical Pharmacology, Quantitative Pharmacology, Pharmacometrics/Pharmacodynamics (PK/PD), Toxicology, Bioanalytical, Therapeutic Focus areas and Clinical Development / Regulatory Affairs teams. This individual contributes to the scientific understanding of PK/PD for assigned projects, based on quantitative evaluation of the pharmacokinetic and pharmacodynamic profile for research programs, through the application of state‑of‑the‑art knowledge in pharmacokinetics and pharmacodynamics.

Discover your role:

• Plans, designs, implements and analyzes routine Pharmacometrics (PMx) studies to advance scientific knowledge, in collaboration with other team members.
• Performs analyses such as NCA, compartmental modeling, PopPK, translational modelling, disease modelling, Pop PK/PD, E‑R analyses to deliver PMx results, interpretation and discussion.
• Collaborates with Scientific Writing to ensure TFLs for PMx reports are complete.
• Works in conjunction with Scientific Writing, Quality Control and QAA to issue study reports in support of IND/CTA submissions and other regulatory documents.
• Supports preparation of material to be used in regulatory interactions.
• Contributes to preparation of PMx materials for regulatory background packages, e.g. for pre‑IND, EOP2, and pre‑BLA meetings.
• Has understanding of advanced PMx concepts and techniques, such as advanced pharmacokinetics, advanced pharmacological principles, non‑compartmental analysis methods, Exposure‑Response analysis methods, translational modelling/pharmacology, Nonlinear Mixed Effects modeling, logistic regression, survival analysis, Bayesian approaches, disease modelling/QSP.
• Is highly skilled in use of relevant software, including MS-Excel, R, R‑Studio, Prism, Phoenix WinNonlin, NLME, STAN and NonMem, working in department computing environment to perform advanced PMx analyses.

This role requires:

• A PhD in Biology, Pharmacology, Engineering or a Pharmacy (Pharm.D.), Medicine (MD) degree.
• 3+ years of relevant Clinical Pharmacology experience.
• Able to communicate effectively with and influence team members from other functions.
• Fully understand processes and are able to represent PMx on process initiatives.

We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief, sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law.

Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits, paid time off, and family support benefits.