Associate Director, Drug Discovery Toxicology in City of London

We are seeking an experienced Drug Discovery Toxicologist who will provide project teams with scientific expertise and leadership for the safety assessment of Recursion programs from early discovery, through to candidate selection and beyond. You will contribute to the assessment and selection of novel drug targets and optimisation of novel candidate molecules using innovative molecular, cellular and in vivo technologies to maximise predictive safety science and investigative toxicology.

Responsibilities

• Represent Toxicology as the Subject Matter Expert on cross-functional project teams within Discovery.
• Provide expert input, guidance and strategy on project safety assessments, with a specific focus on discovery projects.
• Act as a key resource for early safety assessment during the drug discovery phase, providing scientific knowledge and expertise to cross-functional project teams.
• Use established toxicology screening strategies to predict, assess and mitigate target- and drug-related safety risks in support of the drug discovery portfolio.
• Refine and implement innovative experimental strategies and use the data to assess and/or provide mechanistic understanding of safety issues.
• Collaborate with CROs to ensure best practice for in vitro and/or in vivo safety assessment.
• Prepare verbal and written summaries for internal discussions. Work with the Discovery teams to develop optimal strategies to address specific safety issues within the project teams.
• Present summary data to project teams, Recursion senior leadership and external partners as needed.

Team & Collaboration

Reporting to the Head of Toxicology, you will have responsibility for the safety assessment of compounds moving through Discovery and into Development. As the Toxicology subject matter expert, you will work collaboratively with project team members across functions including pharmacology, DMPK and chemistry to support progression of compounds through the portfolio.

The Experience You’ll Need

• DVM, PharmD, PhD in toxicology, Pathology, Physiology, Biochemistry or related disciplines with emphasis on Oncology/Immunology; Board Certification in Toxicology (DABT/ERT) is a plus.
• 7+ years of experience in safety sciences in the Biotech/Pharma industry.
• Experience in project team membership as a toxicology representative in a matrix environment.
• Experience with in silico and in vitro safety assessment; in vivo safety assessment would be an advantage.
• In-depth knowledge of discovery toxicology and experience designing and critically evaluating exploratory toxicology studies.
• Experience of secondary pharmacology assessment would be an advantage.
• Understanding of in vitro to in vivo translation of potential toxicities and implications for human safety.
• Broad background in novel methods of identifying potential toxicities and developing risk mitigation plans.
• Experience with the use of AI tools to predict toxicology endpoints would be an advantage.
• Highly motivated scientist who can work independently, with excellent oral and written communication skills.

Working Location & Compensation

This is an office-based, hybrid role based in either our New York City or London office. Employees are expected to work in the office at least 50% of the time. Relocation support can be provided for this role. Based on the skill and level of experience required, the estimated current annual base range for this role is:

• $182,700 - 229,900 USD for candidates based in the United States.
• £93,500 - £109,700 GBP for candidates based in the United Kingdom.

You will also be eligible for an annual bonus and equity compensation, as well as a comprehensive benefits package.

The Values We Hope You Share

• We act boldly with integrity.
• We care deeply and engage directly.
• We learn actively and adapt rapidly.
• We move with urgency because patients are waiting.
• We take ownership and accountability.
• We are One Recursion.

More About Recursion

Recursion (NASDAQ: RXRX) is a clinical stage TechBio company leading the space by decoding biology to radically improve lives. Enabling its mission is the Recursion OS, a platform built across diverse technologies that continuously generate one of the world’s largest proprietary biological and chemical datasets. Recursion leverages sophisticated machine-learning algorithms to distill from its dataset a collection of trillions of searchable relationships across biology and chemistry unconstrained by human bias. By commanding massive experimental scale — up to millions of wet lab experiments weekly — and massive computational scale — owning and operating one of the most powerful supercomputers in the world, Recursion is uniting technology, biology and chemistry to advance the future of medicine.

Recursion is headquartered in Salt Lake City, where it is a founding member of BioHive, the Utah life sciences industry collective. Recursion also has offices in Toronto, Montréal, New York, London, Oxford area, and the San Francisco Bay area.

Recursion is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, veteran status, or any other characteristic protected under applicable federal, state, local, or provincial human rights legislation. Accommodations are available on request for candidates taking part in all aspects of the selection process.