At a Glance
- Tasks: Lead the validation of TCR engagers for cancer immunotherapy development.
- Company: Join a pioneering biotech company revolutionising cancer treatments.
- Benefits: Enjoy competitive pay, remote work flexibility, and a supportive team culture.
- Other info: Opportunity for career progression in a flat hierarchy where your contributions matter.
- Why this job: Be part of groundbreaking research with real-world impact in a collaborative environment.
- Qualifications: PhD in relevant fields with industry experience in bispecific or T-cell engager development.
The predicted salary is between 48000 - 84000 £ per year.
Are you an ambitious scientist with a PhD and/or industry experience in bispecific or T-cell engager development, eager to accelerate novel cancer immunotherapies?
Join a pioneering biotechnology company at the forefront of engineering TCR engagers for immuno-oncology application. This role is critical to advancing novel therapeutic candidates rapidly towards clinical development, with an IND submission targeted within a year.
The client are seeking a dynamic Senior or Principal Scientist to lead crucial in vivo and in vitro validation of TCR engagers .
This role specifically requires bispecific or T-cell engager experience with IND-enabling processes .
Your technical responsibilities will span:
- TCR design and characterization .
- Protein science operations , including expression, purification, and biophysical analysis (e.g., SPR - experience preferred but not essential).
- Molecular biology duties such as cloning, mutagenesis, DNA isolation, and preparing libraries for deep sequencing (emphasis on cloning and PCR preferred).
- Cellular and immunological assays (e.g., cell killing assays, flow cytometry, IncuCyte-based assays, ELISA).
- Tissue culture management .
- Experience with NGS analysis pipelines (specifically data analysis using R) is desired.
- Experience overseeing outsourced in vivo studies (without needing to have performed them yourself) is a plus.
You\'ll thrive in a flat hierarchy where everyone contributes hands-on. This is a fantastic opportunity for career progression, offering a highly collaborative and supportive cross-disciplinary environment. The client offers very competitive compensation, with flexibility for remote work as project demands allow.
If you hold a PhD in Immunology, Cell Biology, Biochemistry, or a related field with 1-2+ years (Senior) or 3+ years (Principal) of relevant industry experience, and possess critical experience with bispecific or TCR engager validation towards IND, apply now to learn more about this impactful role!
Senior / Principal Scientist in Sheffield employer: RBW Consulting
Join a pioneering biotechnology company that champions innovation and collaboration in the fight against cancer. With a strong focus on employee growth, we offer a dynamic work culture where your contributions are valued, and you can thrive in a flat hierarchy. Enjoy competitive compensation, flexible remote work options, and the opportunity to be at the forefront of developing novel immunotherapies that make a real difference in patients' lives.
StudySmarter Expert Advice🤫
We think this is how you could land Senior / Principal Scientist in Sheffield
✨Tip Number 1
Network with professionals in the biotechnology and immuno-oncology fields. Attend relevant conferences, webinars, or workshops to meet potential colleagues and learn about the latest advancements. This can help you gain insights into the company culture and the specific skills they value.
✨Tip Number 2
Engage with the company's online presence. Follow them on social media platforms like LinkedIn and Twitter to stay updated on their projects and initiatives. Commenting on their posts or sharing relevant content can help you get noticed by their hiring team.
✨Tip Number 3
Prepare for potential interviews by brushing up on your knowledge of bispecific antibodies and T-cell engagers. Be ready to discuss your previous experiences in detail, especially any IND-enabling processes you've been involved in, as this will demonstrate your suitability for the role.
✨Tip Number 4
Consider reaching out to current or former employees of the company for informational interviews. This can provide you with valuable insights into the role and the company’s expectations, helping you tailor your approach when applying through our website.
We think you need these skills to ace Senior / Principal Scientist in Sheffield
Some tips for your application 🫡
Tailor Your CV:Make sure your CV highlights your relevant experience in bispecific or T-cell engager development. Emphasise any specific projects or roles that align with the job description, particularly those involving IND-enabling processes.
Craft a Compelling Cover Letter:Write a cover letter that showcases your passion for cancer immunotherapy and your specific expertise in TCR engagers. Mention how your background aligns with the company's goals and how you can contribute to their innovative projects.
Highlight Technical Skills:In your application, clearly outline your technical skills related to protein science operations, molecular biology, and cellular assays. If you have experience with NGS analysis pipelines or overseeing outsourced studies, make sure to include that as well.
Showcase Collaborative Experience:Since the role emphasises a collaborative environment, provide examples of past experiences where you worked effectively in teams. Highlight your ability to thrive in a flat hierarchy and contribute hands-on to projects.
How to prepare for a job interview at RBW Consulting
✨Showcase Your Technical Expertise
Be prepared to discuss your experience with bispecific or T-cell engagers in detail. Highlight specific projects where you contributed to TCR design, protein science operations, or molecular biology tasks. This will demonstrate your hands-on knowledge and suitability for the role.
✨Familiarise Yourself with IND Processes
Since the role involves advancing therapeutic candidates towards IND submission, make sure you understand the IND-enabling processes. Be ready to discuss how your previous work aligns with these requirements and any relevant experiences you've had in this area.
✨Prepare for Collaborative Scenarios
Given the flat hierarchy and collaborative environment, think of examples where you've successfully worked in teams. Be ready to share how you contribute to group dynamics and support cross-disciplinary efforts, as this is crucial for the company's culture.
✨Demonstrate Problem-Solving Skills
Expect questions that assess your problem-solving abilities, especially in relation to experimental challenges. Prepare to discuss specific instances where you overcame obstacles in your research or project work, particularly in cellular and immunological assays.
