Modelling & Simulation Research Fellow in Nottingham

Modelling & Simulation Research Fellow role at Quotient Sciences

Quotient Sciences is a leading drug development and manufacturing accelerator, helping biotech and pharma companies bring new medicines to patients faster. With over 35 years of experience and a track record of success, we provide Drug Product (CDMO) and Clinical (CRO) services across the entire development pathway, including formulation development, clinical pharmacology, clinical trials, and commercial product manufacturing.

Our proprietary and disruptive platform – “Translational Pharmaceutics®” – integrates Drug Product Manufacturing and Clinical Testing to eliminate silos in the drug development process, reducing costs, improving outcomes, and significantly accelerating drug development times.

Why Join Us

Because every day counts when bringing new medicines to patients. Our 1,000+ experts across the US, UK, and beyond are united by science, agility, and a culture that turns ideas into impact – fast.

Role Overview

This is a unique opportunity to become part of a passionate and collaborative team of PBPK modellers, dedicated to advancing drug development through cutting‑edge modelling and simulation. Our work spans an exciting spectrum—from first‑in‑human (FiH) pharmacokinetic and dose predictions, formulation risk assessments, and model‑informed formulation design in Translational Pharmaceutics® programmes, to virtual bioequivalence predictions for marketed drugs.

Responsibilities

• Build, test, and verify mechanistic PBPK/PBBM models to predict absorption and systemic exposure for small molecules, oral peptides, and other challenging modalities. Conduct sensitivity analyses and refine models to support decision‑making.
• Translate data into insight by linking in‑vitro DMPK/biopharm data and clinical results to model structures. Design and interpret in‑vitro/in‑vivo studies in the context of ADME and formulation strategy.
• Advise on study design and formulation choices (e.g., enteric‑coated OSD, modified release, IVIVC, virtual bioequivalence, food/PPI effects) to de‑risk first‑in‑human and early clinical plans.
• Collaborate in integrated programmes leveraging our Translational Pharmaceutics® platform—connecting model predictions to real‑time clinical feedback to accelerate optimisation.
• Client interactions: present expert conclusions from M&S work to Quotient and client project teams throughout the project life‑cycle.
• Author high‑quality reports that clearly present and summarise M&S project findings.
• Support proposals and client engagement alongside Drug Development Consultants and BD, articulating the value of model‑informed development.
• Critically review client data packages and prepare proposals for potential new M&S projects.

What You Will Bring

• Education: A minimum of a degree‑level qualification.
• Experience: Significant experience in biopharmaceutics, PK data analysis, PK modelling, DMPK and/or clinical pharmacology, including designing and interpreting scientific studies to address key objectives.
• Core expertise: Strong track record of building and applying PBPK models (ideally with GastroPlus™), along with biopharmaceutics, PK data analysis, and clinical pharmacology expertise.
• Tools & platforms: Proficiency with GastroPlus™ and familiarity with Simcyp®, PK‑Sim®, MoBi®, Phoenix/WinNonlin.
• Applied impact: Practical experience predicting human PK from preclinical data, constructing bespoke compartmental absorption/PK models, and informing formulation decisions using in‑silico simulations.
• Communication: Excellent communication skills, able to present clearly and translate complex modelling outputs into actionable development recommendations for diverse audiences.

Application Requirements

Applicants must be aged 18 years or over and not have been debarred by the FDA. Under‑18 or debarred applicants will have their application automatically declined.

Our Commitment to Diversity, Equity and Inclusion

Quotient Sciences are advocates for positive change and conscious inclusion. We strive to create a diverse workforce and a workplace culture that provides a sense of acceptance for every person within our organization. We will not discriminate on the basis of race, color, creed, religion, gender, gender identity, pregnancy, marital status, partnership status, domestic violence victim status, sexual orientation, age, national origin, alienage or citizenship status, veteran or military status, disability, medical condition, genetic information, caregiver status, unemployment status or any other characteristic prohibited by federal, state and/or local laws. This applies to all aspects of employment, including hiring, promotion, demotion, compensation, training, working conditions, transfer, job assignments, benefits, layoff, and termination.

Seniority level

Mid‑Senior level

Employment type

Full‑time

Job function

Research, Analyst, and Information Technology

Industries

Pharmaceutical Manufacturing