At a Glance
- Tasks: Join a cutting-edge research team to develop innovative human disease models.
- Company: Be part of a high-profile UKRI-funded interdisciplinary research programme.
- Benefits: Enjoy strong mentorship, career development, and generous holiday allowance.
- Other info: Collaborate with international experts in a vibrant, inclusive research environment.
- Why this job: Make a real impact in understanding complex metabolic diseases and therapeutic discovery.
- Qualifications: PhD/DPhil in a relevant discipline with expertise in stem cell and adipose tissue biology.
The predicted salary is between 35000 - 45000 £ per year.
We are seeking a highly motivated Postdoctoral Research Associate (PDRA) to join the MIMIC programme: "An interconnected multi‑organ platform to recreate the complex pathophysiology of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)", a major UKRI-funded, interdisciplinary research initiative involving leading academic, clinical, and industrial partners across the UK, Europe, and the USA. MASLD is a complex multisystem metabolic disease involving pathological cross‑talk between the liver, adipose tissue, gut, and immune system. The MIMIC programme aims to develop human, immunocompetent, patient‑derived multi‑organ models, using induced pluripotent stem cells (iPSCs) and organ‑on‑chip technologies, to better understand disease mechanisms and accelerate therapeutic discovery. This PDRA post focuses on the development and characterisation of iPSC‑derived adipose tissue models and their integration into multi‑tissue platforms.
The successful candidate will play a central role in contributing to the generation of biomimetic, immunocompetent adipose tissue constructs derived from human iPSCs. Working closely with stem cell biologists, immunologists, and bioengineers across the MIMIC consortium, the PDRA will:
- Develop and optimise iPSC‑derived adipocyte differentiation protocols
- Generate 3D adipose tissue organoids incorporating stromal, endothelial, and immune cell populations
- Perform in‑depth molecular, phenotypic and metabolic characterisation of adipose models
- Investigate inflammatory and metabolic dysfunction relevant to MASLD
- Contribute to multi‑organ integration, i.e. adipose‑liver‑gut cross‑talk
- Support benchmarking of in‑vitro findings against clinical and patient‑derived data
You will hold a PhD/DPhil or equivalent in a relevant discipline along with:
- Strong hands‑on experience of stem cell‑derived models
- Demonstrated expertise in adipose tissue biology and adipocyte differentiation
- Experience with 3D cell culture, organoid systems, or co‑culture models
- Solid grounding in molecular and cellular biology techniques
- Ability to work both independently and collaboratively within a large interdisciplinary programme
Informal enquiries are welcome and may be directed to: Jaswinder Sethi ( j.sethi@soton.ac.uk ). Please note that applications sent only to this email address will not be accepted.
What we offer:
- An exciting post within a high‑profile UKRI‑funded research programme
- Access to world‑class facilities and international collaborators
- Strong mentorship and career development, including training and conference support
- Opportunities for collaboration, secondments, and interdisciplinary skills development
- A generous holiday allowance as well as additional university closure days
- A vibrant, inclusive, and supportive research environment
We are committed to equality, diversity and inclusion and welcome applicants who support our mission of inclusivity.
£36,636 to £41,064. Per Annum
Research Fellow in In Vitro Models of Human Disease in Southampton employer: PVH (Tommy Hilfiger/Calvin Klein)
Intapp is an exceptional employer, offering a dynamic work environment that fosters innovation and collaboration within the accounting and consulting sectors across EMEA. With a strong commitment to employee growth, Intapp provides ample opportunities for professional development and leadership coaching, ensuring that team members thrive in their careers while contributing to the company's strategic vision. The culture is built on accountability and high performance, making it an ideal place for those looking to make a significant impact in a rapidly evolving industry.
Contact Details:
PVH (Tommy Hilfiger/Calvin Klein) Recruitment Team
StudySmarter Expert Advice🤫
We think this is how you could land Research Fellow in In Vitro Models of Human Disease in Southampton
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We think you need these skills to ace Research Fellow in In Vitro Models of Human Disease in Southampton
Some tips for your application 🫡
Highlight Your Research Experience:When applying for a full-time role in scientific research, make sure to emphasise your research experience prominently in your CV. Share specific projects you’ve worked on, the methodologies you used, and any significant findings. If you’ve published papers or presented at conferences, definitely include that too – it shows you’re on it in the academic world!
Tailor Your Cover Letter to the Research Area:Your cover letter should reflect your passion for the specific area of research at PVH (Tommy Hilfiger/Calvin Klein). Mention relevant experiences that align with the organisation’s goals or projects. This shows that you’ve done your homework and are genuinely interested in the position – plus, it helps us see how you’d fit into the team dynamics.
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Discuss Your Future Research Goals:In your motivation section, it’s a great idea to talk about your future research goals and how they align with the work being done at PVH (Tommy Hilfiger/Calvin Klein). This shows that you’re not just looking for any job, but rather a chance to contribute meaningfully to the field. We love to see applicants who are forward-thinking and enthusiastic about their research journey!
How to prepare for a job interview at PVH (Tommy Hilfiger/Calvin Klein)
✨Showcase Your Research Skills
In scientific research, it’s crucial to demonstrate your ability to design and conduct experiments. Come armed with examples of past projects where you've developed hypotheses, collected data, and analysed results. Be ready to discuss any specific methodologies or tools you’ve used, like PCR techniques or statistical software.
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✨Exhibit Your Team Spirit
In full-time roles, collaboration is often at the heart of scientific research. Prepare examples that show how you've successfully worked in teams, dealt with conflicts, or contributed to group projects. We want to know how you can work effectively with the team at PVH (Tommy Hilfiger/Calvin Klein) to drive research projects forward.
