At a Glance
- Tasks: Analyse large-scale epigenomic datasets and develop bioinformatic pipelines.
- Company: Join the UK Dementia Research Institute at Imperial College London.
- Benefits: Competitive salary, career development, and access to cutting-edge technologies.
- Other info: Collaborative environment with opportunities to mentor and teach students.
- Why this job: Make a real impact in dementia research and contribute to innovative therapeutic solutions.
- Qualifications: Strong programming skills and experience with genomic datasets required.
The predicted salary is between 47223 - 47223 £ per year.
About the role
Launched in 2017, the UK Dementia Research Institute stands as a beacon of scientific innovation, representing an unprecedented £300 million investment in dementia research - the largest of its kind in UK history.
The purpose of the UK DRI is to transform the outlook for people living with or at risk of neurodegenerative conditions through research.
We are inviting applications for a Research Assistant in computational brain vascular epigenomics, funded by the Uren Foundation, to join the laboratory of Dr Alexi Nott ( https://nottgroup. com/index. html ) in the UK DRI at Imperial College London .
Vascular dysfunction is one of the earliest pathological features of dementia, preceding clinical onset and representing a critical but underexplored window for therapeutic intervention.
Our recent work has demonstrated that the brain neurovascular unit is a key driver of genetic risk for small vessel disease, and that epigenomic profiling of vascular cell types can be used to prioritise repurposable drug targets for dementia (Ziegler et al., Neuron , 2026This work carries direct translational potential, with the opportunity to contribute to the prioritisation of both repurposable and novel therapeutic candidates underpin. ed by human epigenetic and genetic evidence.
What you would be doing
Using your experience in (epi)genomics of the brain, you will
- Lead the analysis of analyse large-scale epigenomic and multi-omics datasets from human vascular and immune cell types.
- Develop and maintain bioinformatic pipelines and analytical workflows, applying rigorous standards to ensure robust and reproducible results.
- Contribute to the functional interpretation of noncoding disease risk variants linked to vascular dysfunction, guiding the identification of genetically supported therapeutic targets.
- Work collaboratively as part of a multidisciplinary research team, including computational scientists and experimentalists, within the UK DRI and with external collaborators.
- What we are looking for
We are seeking a motivated and organised researcher who is excited by the science we do! You will have:
- Strong programming skills in R, Python, or other coding languages (e. g.
C++, Matlab), with knowledge of Unix/Linux environments and version control systems such as Git and Git Hub.
- Experience working with large-scale genomic datasets, ideally CUT&Tag, and/or ATAC-seq, Ch IP-seq, single-cell/nucleus genomics, RNA-seq.
- Experience with high-performance computing environments and the development of bioinformatic workflows using tools such as Nextflow.
- Knowledge of chromatin biology, gene regulation, and/or vascular and immune cell types, ideally in the context of the brain, is highly desirable.
- Experience working with GWAS summary statistics and/or population genetic analyses would be advantageous.
- What we can offer you
This role is part of the UK Dementia Research Institute (UK DRI) at Imperial College London , located in the Department of Brain Sciences.
- Researchers in the UK DRI at Imperial enjoy excellent career development opportunities with: Access to a range of cutting-edge technologies.
- An inclusive and collegial working environment with the opportunity to mentor, supervise and teach students.
- Strong national links through the UK DRI and attendance at relevant scientific meetings.
- The opportunity to continue your career at a world-leading institution and be part of our mission to continue science for humanity.
This is a full time fixed term role, based at our White City Campus. If you require any further details about the role, please contact: Dr Alexi Nott a. nott@imperial. ac. uk
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Research Assistant in Brain Vascular Epigenomics - UK Dementia Research Institute employer: PVH (Tommy Hilfiger/Calvin Klein)
Intapp is an exceptional employer, offering a dynamic work environment that fosters innovation and collaboration within the accounting and consulting sectors across EMEA. With a strong commitment to employee growth, Intapp provides ample opportunities for professional development and leadership coaching, ensuring that team members thrive in their careers while contributing to the company's strategic vision. The culture is built on accountability and high performance, making it an ideal place for those looking to make a significant impact in a rapidly evolving industry.
Contact Details:
PVH (Tommy Hilfiger/Calvin Klein) Recruitment Team
StudySmarter Expert Advice🤫
We think this is how you could land Research Assistant in Brain Vascular Epigenomics - UK Dementia Research Institute
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We think you need these skills to ace Research Assistant in Brain Vascular Epigenomics - UK Dementia Research Institute
Some tips for your application 🫡
Highlight Your Research Experience:When applying for a full-time role in scientific research, make sure to emphasise your research experience prominently in your CV. Share specific projects you’ve worked on, the methodologies you used, and any significant findings. If you’ve published papers or presented at conferences, definitely include that too – it shows you’re on it in the academic world!
Tailor Your Cover Letter to the Research Area:Your cover letter should reflect your passion for the specific area of research at PVH (Tommy Hilfiger/Calvin Klein). Mention relevant experiences that align with the organisation’s goals or projects. This shows that you’ve done your homework and are genuinely interested in the position – plus, it helps us see how you’d fit into the team dynamics.
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Discuss Your Future Research Goals:In your motivation section, it’s a great idea to talk about your future research goals and how they align with the work being done at PVH (Tommy Hilfiger/Calvin Klein). This shows that you’re not just looking for any job, but rather a chance to contribute meaningfully to the field. We love to see applicants who are forward-thinking and enthusiastic about their research journey!
How to prepare for a job interview at PVH (Tommy Hilfiger/Calvin Klein)
✨Showcase Your Research Skills
In scientific research, it’s crucial to demonstrate your ability to design and conduct experiments. Come armed with examples of past projects where you've developed hypotheses, collected data, and analysed results. Be ready to discuss any specific methodologies or tools you’ve used, like PCR techniques or statistical software.
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✨Know Your Publications
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