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- Tasks: Lead DMPK strategy and collaborate on innovative drug development projects.
- Company: Dynamic biotechnology company shaping the future of healthcare.
- Benefits: Competitive salary, performance bonuses, comprehensive health benefits, and generous time-off.
- Other info: Join a passionate team and enjoy excellent career growth opportunities.
- Why this job: Make a meaningful impact on transformative therapies in a fast-paced environment.
- Qualifications: PhD in pharmacokinetics with 10+ years of DMPK experience.
Are you ready to make a groundbreaking impact in the world of biotechnology? Join a growing company that's shaping the future of healthcare and science. Proclinical is seeking a highly motivated Director, DMPK to join an innovative, clinical-stage biotechnology environment focused on advancing novel small-molecule therapies for immune-mediated inflammatory diseases. This is a senior scientific leadership role offering the opportunity to shape DMPK strategy from discovery through clinical development in a fast-paced, collaborative setting.
The Role:
As Director, DMPK, you will provide technical and scientific leadership across discovery and development programs, serving as the DMPK subject matter expert and program lead. You will define and execute ADME, PK, and PK-PD strategies, support key development decisions, and play a critical role in first-in-human dose predictions and regulatory submissions. You will work cross-functionally with medicinal chemistry, toxicology, pharmacology, CMC, and clinical teams, and manage external partners to ensure high-quality, timely DMPK execution.
Key Responsibilities
- Lead and implement DMPK and PK-PD strategies aligned with discovery and development objectives
- Serve as DMPK program lead, responsible for study design, execution, analysis, interpretation, and reporting
- Provide expert interpretation of DMPK data and present findings to project teams, senior leadership, and external stakeholders
- Collaborate closely across R&D functions to enable data-driven decision-making
- Oversee bioanalytical and DMPK studies conducted internally and through CROs
- Author and review PK/DMPK sections of regulatory documents (IND, IB, CTA, NDA/BLA) and respond to regulatory inquiries
- Support clinical pharmacology activities, including first-in-human dose projections
- Maintain high standards of scientific rigor, quality, and documentation
Qualifications
- PhD in pharmacokinetics, drug metabolism, or a related discipline
- 10+ years of small-molecule DMPK experience in the pharmaceutical or biotechnology industry
- Proven track record leading DMPK efforts across discovery and development
- Experience with clinical candidate selection and translational PK/PD
- Hands-on experience analyzing PK and PK-PD data using relevant software tools
- Strong understanding of regulatory guidelines supporting small-molecule drug development
- Experience preparing regulatory submissions and interacting with U.S. and international regulatory agencies
- Ability to oversee bioanalytical method development and validation
Leadership & Skills
- Influential scientific leader with direct accountability for DMPK strategy
- Excellent written and verbal communication skills
- Strong analytical and problem-solving abilities
- Detail-oriented, adaptable, and comfortable working hands-on in a small, fast-moving organization
Compensation & Benefits
- Salary: US$190,000 - US$240,000 (commensurate with experience)
- Eligibility for performance-based bonuses and/or equity compensation
- Comprehensive benefits package including health, dental, vision, 401(k), generous time-off programs, paid parental leave, and additional insurance offerings
This role offers a unique opportunity to make a meaningful impact on the development of transformative therapies while working alongside a passionate, high-calibre team.
Director DMPK in San Francisco employer: Proclinical
Contact Detail:
Proclinical Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Director DMPK in San Francisco
✨Tip Number 1
Network like a pro! Reach out to your connections in the biotech field, especially those who are already working in DMPK roles. A friendly chat can lead to insider info about job openings or even referrals.
✨Tip Number 2
Prepare for interviews by brushing up on your DMPK knowledge and recent advancements in the field. We recommend practising common interview questions and having examples ready that showcase your leadership and problem-solving skills.
✨Tip Number 3
Don’t underestimate the power of follow-ups! After an interview, send a thank-you email to express your appreciation and reiterate your enthusiasm for the role. It keeps you fresh in their minds and shows your professionalism.
✨Tip Number 4
Apply through our website for the best chance at landing that Director, DMPK role. We make it easy for you to showcase your skills and experience directly to the hiring team, so don’t miss out!
We think you need these skills to ace Director DMPK in San Francisco
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to the Director DMPK role. Highlight your relevant experience in pharmacokinetics and drug metabolism, and don’t forget to showcase your leadership skills. We want to see how you can make a groundbreaking impact!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you're passionate about biotechnology and how your background aligns with our mission. We love seeing enthusiasm and a clear connection to the role.
Showcase Your Achievements: When detailing your experience, focus on specific achievements in DMPK strategy and execution. Use metrics where possible to demonstrate your impact. We’re looking for someone who can lead and innovate!
Apply Through Our Website: Don’t forget to apply through our website! It’s the best way for us to receive your application and ensures you’re considered for this exciting opportunity. We can’t wait to hear from you!
How to prepare for a job interview at Proclinical
✨Know Your DMPK Inside Out
Make sure you brush up on your knowledge of drug metabolism and pharmacokinetics. Be prepared to discuss specific strategies you've implemented in past roles, especially those that align with the company's focus on small-molecule therapies.
✨Showcase Your Leadership Skills
As a Director, you'll need to demonstrate your ability to lead cross-functional teams. Prepare examples of how you've successfully collaborated with medicinal chemistry, toxicology, and clinical teams to drive projects forward.
✨Prepare for Regulatory Discussions
Since this role involves authoring regulatory documents, be ready to discuss your experience with INDs, CTAs, and BLAs. Highlight any interactions you've had with regulatory agencies and how you navigated challenges in submissions.
✨Communicate Clearly and Confidently
Strong communication skills are key for this position. Practice articulating complex DMPK concepts in a way that's easy to understand. Be prepared to present your findings and strategies clearly to both technical and non-technical stakeholders.