About the Role
Our client, a distinguished pharmaceutical research company, is seeking an accomplished Senior Synthetic Organic Chemist to join their innovative drug discovery team. This integral role will be based at their state-of-the-art research facility in Randburg, Gauteng. The Senior Synthetic Organic Chemist will be responsible for designing and executing complex multi-step syntheses of novel small molecules, intermediates, and drug candidates. This position requires a deep expertise in organic synthesis, a strong understanding of reaction mechanisms, and a passion for medicinal chemistry. The role offers a unique opportunity to contribute to the development of life-saving therapies and work alongside a team of highly skilled scientists in a collaborative environment within the vibrant Gauteng province. We are committed to scientific excellence and fostering an environment where innovation thrives.
Key Responsibilities
- Design and implement efficient synthetic routes for target molecules, including complex natural products and drug candidates.
- Perform reactions from milligram to multi-gram scale.
- Purify synthesized compounds using chromatographic techniques (e.g., flash chromatography, HPLC).
- Characterize synthesized compounds using spectroscopic methods (e.g., NMR, MS, IR).
- Troubleshoot synthetic challenges and optimize reaction conditions.
- Collaborate closely with medicinal chemists to iterate on structure-activity relationships (SAR).
- Maintain detailed and accurate laboratory notebooks.
- Stay updated on the latest advancements in synthetic organic chemistry and relevant literature.
- Ensure compliance with all laboratory safety protocols and procedures.
- Contribute to patent filings and scientific publications.
Requirements
- PhD in Organic Chemistry or a closely related field.
- Minimum of 6 years of postdoctoral or industry experience in synthetic organic chemistry, with a strong focus on medicinal chemistry.
- Demonstrated expertise in designing and executing complex multi-step syntheses.
- Proficiency with modern synthetic techniques and purification methods.
- Strong hand-on experience with spectroscopic characterization techniques (NMR, MS).
- Knowledge of reaction mechanisms and stereochemistry.
- Excellent problem-solving skills and meticulous attention to detail.
- Strong written and verbal communication skills.
- Ability to work independently and as a contributing member of a research team.
- Experience with handling air- and moisture-sensitive reagents is essential.
- Commitment to working in Randburg, Gauteng.
Benefits
- Our client offers a competitive salary, comprehensive health and retirement benefits, performance-based incentives, and ample opportunities for professional growth and development.
- This role provides a chance to make a significant impact on drug discovery in the dynamic landscape of Gauteng.
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