About the Role
Our client, a dynamic biopharmaceutical company at the forefront of developing novel therapeutics, is seeking a talented Biochemist to contribute to their groundbreaking drug discovery programs. This role is ideal for a scientist passionate about understanding disease mechanisms at a molecular level and translating this knowledge into potential life‑saving treatments. The position involves working within a state‑of‑the‑art laboratory environment, focusing on target validation, assay development, and small molecule screening. While the role is primarily based in our **Tembisa** laboratory, a hybrid work model is offered, providing flexibility for remote work on designated days. You will be an integral part of a collaborative team dedicated to pushing the boundaries of medicinal chemistry and pharmacology, making a real difference in patient lives.
Key Responsibilities
- Develop and optimize biochemical and cellular assays for target validation and drug screening.
- Perform high-throughput screening (HTS) campaigns to identify novel drug candidates.
- Characterize the potency, selectivity, and mechanism of action of lead compounds.
- Conduct in vitro studies to assess drug metabolism and pharmacokinetic properties.
- Analyze experimental data using statistical software and present findings to the research team.
- Contribute to the design of structure‑activity relationship (SAR) studies.
- Collaborate closely with medicinal chemists, biologists, and pharmacologists.
- Maintain detailed and accurate laboratory records.
- Troubleshoot experimental issues and propose solutions.
- Contribute to the preparation of manuscripts and patent applications.
Requirements
- M.Sc. or Ph.D. in Biochemistry, Pharmacology, Molecular Biology, or a related discipline.
- Minimum of 3 years of experience in drug discovery or a related field.
- Hands‑on experience with a variety of biochemical techniques (e.g., enzyme kinetics, binding assays).
- Proficiency in assay development and validation for HTS.
- Experience with mammalian cell culture and cell‑based assays.
- Familiarity with data analysis software (e.g., GraphPad Prism, R).
- Strong understanding of drug discovery principles and methodologies.
- Excellent problem‑solving and analytical skills.
- Ability to work effectively in a team‑oriented environment.
- Good oral and written communication skills.
Benefits
Our client provides a competitive remuneration package including a substantial annual salary, performance‑based bonuses, comprehensive medical, dental, and vision insurance, and a generous pension fund contribution. Employees benefit from ample paid annual leave, sick leave, and study leave for professional development. The hybrid work model offers a balance between on‑site collaboration and remote flexibility. Opportunities for career advancement are actively supported through training programs, conference attendance, and internal mobility. A relocation assistance package may be available for successful candidates relocating to the **Tembisa** area.
Biochemist - Drug Discovery in Birmingham employer: Placements24
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