Scientist / Senior Scientist – Discovery Bioanalysis & Biotransformation in Hoddesdon

Location: Hoddesdon, Hertfordshire, UK.

Pharmaron is a global CRO helping pharma and biotech companies bring new therapies to life. We support drug discovery through to manufacturing with integrated, high‑quality services.

We are looking for a Scientist and a Senior Scientist to join our Discovery Bioanalysis and Biotransformation team in Hoddesdon. These roles will deliver fast‑paced discovery projects, providing high‑quality LC‑MS data across a broad range of in vitro and in vivo studies.

• Perform laboratory‑based bioanalysis using LC‑MS/MS to support discovery bioanalysis and biotransformation studies.
• Prepare and analyse samples from in vitro and in vivo studies, supporting rapid turnaround of high‑quality data.
• Develop, optimise and troubleshoot LC‑MS/MS methods for the analysis of small molecules, peptides and other discovery‑stage compounds including proteins.
• Support high‑throughput analytical workflows, including sample preparation, data generation, data review and reporting.
• Work closely with colleagues across discovery groups, to enable support of in‑vitro and in‑vivo workflows.
• Contribute to pharmacokinetic analysis and interpretation, where appropriate.
• Support metabolite identification and structural elucidation activities using higher‑end mass spectrometry platforms.

• BSc or MSc in Chemistry, Biochemistry, Pharmacology, Biological Sciences or another relevant scientific discipline.
• An interest in bioanalysis, DMPK & ADME.
• Some exposure to LC‑MS, either through industry placement, postgraduate study or relevant academic projects.
• Strong attention to detail and a commitment to producing high‑quality data.
• Good written and verbal communication skills.
• Ability to work both independently and as part of a close, collaborative team.
• Proactive, curious and willing to learn new techniques, systems and scientific approaches.
• Organised, adaptable and comfortable working in a fast‑paced laboratory environment.

• Minimum 3 years’ relevant industry experience in bioanalysis using LC‑MS to support qualitative and quantitative analysis.
• Strong hands‑on experience with LC‑MS method development, optimisation, routine sample analysis and troubleshooting.
• Experience working in a high‑throughput analytical or discovery‑focused environment.
• Use of Python coding would be beneficial.
• Experience in sample extraction techniques and the use of automation platforms (Tecan D300, Agilent Bravo).
• Ability to work with greater independence and take ownership of assigned studies or workstreams.
• Good understanding of pharmacokinetic analysis, in vitro systems, DMPK and/or ADME workflows.
• Confidence communicating scientific updates and supporting project discussions.
• Experience supporting or mentoring more junior scientists would be advantageous.

• Use of Sciex MS instrumentation and associated software (Analyst and Sciex OS).
• Experience of Discovery MET‑ID using QTOF instrumentation and structural elucidation.
• Experience of using WinNonLin for PK analysis.
• Use of Python coding.

• Exposure across LC‑MS/MS bioanalysis, in vitro ADME support, in vivo PK analysis, metabolite ID and high‑throughput discovery workflows.
• Work on varied client projects across early‑stage drug discovery.
• Collaborative, supportive and technically strong team environment.
• Opportunities to develop expertise and progress within a fast‑paced CRO environment.