Scientist I

As a Scientist I, you will support internal R&D projects, client projects and drug discovery programmes in the context of an early-stage AI drug discovery company. You will focus on performing aptamer discovery pipelines as part of our AI-wet-lab feedback loop, for therapeutic and diagnostic applications. This position will also support and perform biophysical, biochemical and nucleochemistry functions with respect to the in vitro design and optimisation of aptamer-based cytotoxic conjugates and radiopharmaceuticals. You will play a key role in the progression of internal therapeutic assets through the development of critical pharmacology assays and gain exposure to key aspects of preclinical discovery including in vitro and in vivo pharmacokinetic and efficacy studies.

The position will offer outstanding opportunities to work on state of the art high throughput screening platforms, automation, and work at Imperial, the Translation & Innovation I HUB and London Biofoundry. This role is ideally suited for a motivated experimental scientist who is passionate about oligonucleotides, pharmaceuticals and technology.

PentaBind is the first aptamer discovery company using AI and a fully integrated wet laboratory to design a new generation of alternative oligo therapeutics. Our pioneering platform already improves the experimental search space by 300x, generating therapeutic aptamers for urgent clinical needs within oncology, rare and neurodegenerative diseases. In collaboration with global partners, we also design custom aptamers for a variety of industries including diagnostics, health monitoring, and manufacturing.

Key Responsibilities:

• Perform and optimise aptamer discovery workflows
• Design, execute, and troubleshoot biochemistry and molecular biology experiments
• Execute previously standardised SELEX, NGS, SPR, qPCR, flow cytometry and confocal based studies
• Suggest your own ideas, formulate plans and strategy proposals to present to the senior management
• Maintain excellent documentation of laboratory work
• Analyse and interpret experimental data, providing clear conclusions and recommendations to internal teams
• Support efforts in intellectual property generation, including patents and publications in high impact journals
• Collaborate with the ML scientists, drug discovery, assay development and chemistry teams

Minimum Requirements:

• Have obtained, or currently finishing, a Ph.D degree in biochemistry, chemical biology, cell biology or a relevant discipline
• Outstanding experimental (i.e., lab) skills with an attention to detail
• Experience in molecular biology, biochemistry, and/or drug discovery specifically in hit identification and qualification
• Proficient in mammalian cell culture DNA and protein handling skills
• Excellent communication and interpersonal skills
• Excellent organisational, data archiving and presentation skills
• English language speaking, listening and writing fluency

Nice to Have Requirements:

• Industry experience
• Hands on experience with PCR, nucleic acid QC, and protein QC (e.g., SDS PAGE)
• Experienced in biophysical characterisation of nucleic acid protein or nucleic acid ligand interactions (one of, e.g., SPR, BLI, ELISA, FP)
• Familiarity with delivery systems for nucleic acids, such as lipid nanoparticles or conjugates.
• Publication in a major scientific journal with molecular biology/biochemistry contributions