Senior Director, Program Management in Cambridge

As a member of the Parabilis Medicines team, you will be a part of an organization dedicated to creating extraordinary medicines for diseases with urgent unmet needs, harnessing our proprietary peptide platform to transform treatment possibilities for patients. Parabilis is a clinical-stage biopharmaceutical company dedicated to unlocking high-impact protein targets long-considered undruggable.

The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities. Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers.

Its lead asset, zolucatetide (FOG-001), is a first-in-class, clinically validated direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in millions of cancer cases annually, including in colorectal cancer, desmoid tumors, hepatocellular carcinoma and a range of other Wnt/β-catenin-driven tumors. In Phase 1 clinical trials, zolucatetide produced the first-ever clinical evidence that it can directly inhibit this interaction, once previously considered “undruggable” despite its role across multiple cancer types.

Parabilis is also advancing investigational degraders of ERG and ARON into clinical development for the treatment of prostate cancer, as well as progressing other preclinical programs. Backed by a recent $305 million Series F financing, Parabilis is entering an exciting phase of growth and execution.

What’s the opportunity? Parabilis Medicines is seeking a highly skilled and experienced Senior Director of Program Management with a robust background in oncology drug development. This strategic program managerial role will be responsible for overseeing the planning, execution and delivery of early and mainly late-stage oncology programs, ensuring that projects align with our strategic objectives and are completed on time and within budget.

The Senior Director will coordinate cross-functional teams with the Global Project Team (GPT), drive project strategy in coordination with the Program Development Team Leader (PDTL), and foster communication across the organization.

• Program planning and its execution: Assist the GPT to build and maintain the Integrated Development Strategy Plan and its integrated timelines, track progress against milestones, integrate cross-functional data to help inform decision making, ensure cross-functional awareness and readiness for key activities.
• Risk & budget Management: Identify and mitigate project risks proactively, developing contingency plans to address potential challenges and ensure project success, escalate critical issues with options and team recommendations, assist in managing program budgets and budget forecasting.
• Regulatory: Partner with regulatory team to prepare Health Authorities meetings and submission planning and execution.
• Governance: Coordinate with the GPT to prepare material for governance committees, summarize actions, decisions and ensure follow-up.
• PTDL coordination: Partner to manage the GPT, support the PDTL in ensuring execution of programs decision and strategies.
• Cross-Functional team management: Collaborate with key stakeholders across various functions, including clinical development, clinical operations, regulatory affairs, CMC, finance, commercial, and quality assurance—to ensure effective project execution and alignment.
• Performance Monitoring: Establish key performance indicators (KPIs) and metrics to monitor project progress, providing regular updates to executive leadership and stakeholders.

What you’ll need to be successful:

• Bachelor’s degree in Life Sciences, Pharmacy, or a related field required; advanced degree (e.g., MBA, PhD) preferred.
• 12+ years of project management experience in the biopharmaceutical industry, with a minimum of 5 years in a leadership role focused on oncology drug development.
• Proven track record of successfully managing complex oncology projects through all phases of development, including preclinical and clinical trials.
• Strong understanding of regulatory requirements and industry standards related to drug development and commercialization.
• Exceptional leadership, communication, and interpersonal skills, with the ability to influence and engage senior stakeholders and cross-functional teams.
• Demonstrated ability to think strategically and translate strategies into actionable plans.
• Proficient in project management methodologies and tools (e.g., MS Project, Asana, Trello); PMP or equivalent certification is preferred.
• Strong analytical and problem-solving skills, with a focus on achieving results in a fast-paced environment.
• Demonstrated use of AI tools in your current role and responsibilities is required. Advanced or innovated use of AI is a strong plus.

Core Values: Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded: We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent: We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused: We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In: We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary target for this position is $260,000-300,000, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.