Principal Scientist, Drug Product Development in Cambridge

As a member of the Parabilis Medicines team, you will be a part of an organization dedicated to creating extraordinary medicines for diseases with urgent unmet needs, harnessing our proprietary peptide platform to transform treatment possibilities for patients. Parabilis is a clinical-stage biopharmaceutical company dedicated to unlocking high-impact protein targets long-considered undruggable.

The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities. Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead asset, zolucatetide (FOG-001), is a first-in-class, clinically validated direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in millions of cancer cases annually, including in colorectal cancer, desmoid tumors, hepatocellular carcinoma and a range of other Wnt/β-catenin-driven tumors.

In Phase 1 clinical trials, zolucatetide produced the first-ever clinical evidence that it can directly inhibit this interaction, once previously considered “undruggable” despite its role across multiple cancer types. Parabilis is also advancing investigational degraders of ERG and ARON into clinical development for the treatment of prostate cancer, as well as progressing other preclinical programs. Backed by a recent $305 million Series F financing, Parabilis is entering an exciting phase of growth and execution.

We are seeking a Principal Scientist with deep expertise in drug product formulation development for peptide therapeutics to play a critical role in advancing Parabilis Med’s pipeline and delivery platforms from early development through clinical/commercial stages. This position will lead formulation strategies across multiple delivery modalities (parenteral, oral, and advanced delivery systems), integrate closely with discovery, DMPK, analytical, and CMC teams, and help establish Parabilis Med’s drug product development capabilities.

Key responsibilities:

• Lead formulation development for peptide therapeutics across parenteral (SC/IV/IM), oral, and advanced delivery systems (e.g., nanoparticles, depot formulations)
• Design and optimize dosage forms including injectables, tablets, capsules, and enabling delivery technologies
• Evaluate and implement high concentration peptide formulation, incorporating sustained release, absorption enhancement, and stabilization strategies
• Design and interpret biorelevant in vitro and in vivo studies to support PK/PD and candidate selection
• Contribute to CMC development from early feasibility through IND-enabling and clinical stages
• Support technology transfer, scale-up, and external manufacturing (CRO/CDMO) activities
• Collaborate cross-functionally with DMPK, biology, analytical, and regulatory teams
• Provide technical leadership and mentorship within Pharmaceutical Sciences.

What you'll need to be successful:

• PhD in Pharmaceutics, Pharmaceutical Sciences, Chemical Engineering, Chemistry, or related field
• 8-10+ years of industry experience in drug product development for peptides and/or biologics
• Demonstrated expertise in multiple formulation modalities, including parenteral formulations (SC/IV/IM), and oral dosage forms
• Experience in advanced delivery systems (e.g., nanoparticles, depot formulations) is a plus.
• Strong understanding of biopharmaceutics, stability, release/absorption and in vitro–in vivo translation
• Experience contributing to IND/CTA-enabling CMC activities
• Experience with late-stage or commercial formulations is highly desirable
• Experience working with and managing CRO/CDMO partners
• Strong scientific judgment, problem-solving skills, and communication.

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.

In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.

Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.

All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary range for this position is $165,000-$200,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being. As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.