Principal Associate Scientist, Biology in Cambridge

As a member of the Parabilis Medicines team, you will be a part of an organization dedicated to creating extraordinary medicines for diseases with urgent unmet needs, harnessing our proprietary peptide platform to transform treatment possibilities for patients. Parabilis is a clinical-stage biopharmaceutical company dedicated to unlocking high-impact protein targets long-considered undruggable.

The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities. Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers.

What’s the opportunity? We are seeking an experienced and motivated Principal Associate Scientist to support cellular biochemistry and cell-based assay development for oncology discovery programs within our Biology team. This is a bench facing role central to building screening cascades, developing target engagement strategies, and contributing to mechanism of action understanding across multiple discovery efforts.

Key responsibilities:

• Design and execute target engagement and mechanism-of-action studies to characterize novel therapeutic candidates
• Develop cell-based assays (e.g., NanoBRET, HiBiT, AlphaLISA, HTRF) from conceptualization and proof-of-concept through to validated implementation in collaboration with internal or external cell pharmacology team
• Perform and interpret supporting assays including qPCR, Western blotting, immunoprecipitation, and pulldown assays
• Independently manage experimental workflows, anticipate technical challenges, and drive projects to completion
• Provide technical mentorship and contribute to a collaborative, high-performing team environment
• Maintain high standards of data integrity, documentation, and experimental reproducibility

What you’ll need to be successful:

B.S. or M.S. in Biology, Molecular Biology, Biochemistry, or a related field with 7–10+ years of relevant industry experience.

• Deep expertise in developing and executing cell-based assays (e.g., NanoBRET, HiBiT, AlphaLISA, HTRF)
• Proficiency in molecular and biochemical techniques including qPCR, Western blotting, immunoprecipitation, and pulldown assays
• Experience with cell line engineering (CRISPR/Cas9, viral expression systems)
• Demonstrated ability to independently design, execute, and interpret experiments
• Ability to critically evaluate complex datasets, resolve discrepancies, and communicate clear conclusions to cross-functional stakeholders
• Intellectual curiosity, proactively identifying opportunities to deepen expertise or explore new approaches
• Ability to work on-site in bench-facing capacity and actively participate in in-person collaboration

• Experience with induced proximity or targeted protein degradation approaches
• Experience in oncology drug discovery

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

The base salary range for this position is $108,000-$128,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.