At a Glance
- Tasks: Lead nonclinical pharmacology strategy for oncology programs and contribute to regulatory submissions.
- Company: Join Parabilis Medicines, a pioneering biopharmaceutical company focused on innovative treatments.
- Benefits: Competitive salary, annual bonus, equity, and comprehensive benefits for your well-being.
- Other info: Dynamic, collaborative environment with opportunities for growth and innovation.
- Why this job: Make a real impact in oncology by advancing groundbreaking medicines that change lives.
- Qualifications: PhD in Pharmacology or related field with 8+ years of experience in oncology.
The predicted salary is between 70000 - 90000 £ per year.
About Parabilis Medicines
Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines for patients with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new class of alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that have historically been beyond the reach of conventional medicines. The company’s lead investigational medicine, zolucatetide, is the first and only direct inhibitor of the β-catenin:TCF interaction, a central node in the Wnt/β-catenin pathway that has eluded drug developers for decades. Zolucatetide is being evaluated in the clinic across multiple Wnt/β-catenin-driven diseases, including desmoid tumors, familial adenomatous polyposis (FAP) and a range of other solid tumor indications. Beyond zolucatetide, Parabilis is advancing additional Helicon-based programs focused on other challenging targets where we believe our medicines could have life-altering impact.
What’s the opportunity?
We are seeking an experienced industry nonclinical pharmacology leader with a demonstrated track record of advancing oncology programs from discovery through IND submission. This role will serve as the nonclinical pharmacology lead on one or more oncology programs, accountable for nonclinical pharmacology strategy, including translational planning and IND-enabling study design, and contributing to regulatory pharmacology content. You will be expected to meaningfully contribute to regulatory filings and identify translational forward approaches that target early clinical development goals. Your leadership experience and history of working in a highly matrixed cross functional environment will be key in continuing to move oncology programs forward in a collaborative and scientifically rigorous environment. You will work within the existing pharmacology team framework and report directly to the Head of Pharmacology. Success in this role will require excellent communication, scientific thought leadership, a desire to work in a fast paced team environment and an eagerness to grow as a drug hunter.
Key abilities of this role include:
- Lead nonclinical pharmacology strategy for assigned oncology programs from late discovery through IND submission
- Design, oversee, interpret, and communicate in vivo PK/PD and efficacy studies (internally and via CRO partnerships)
- Contribute to IND-enabling study design and author or co-author relevant pharmacology sections of regulatory submissions
- Integrate pharmacology data with DMPK, safety, and biomarker findings to inform development decisions
- Clearly present data and strategy updates to senior leadership and governance teams
- Inspire and mentor junior pharmacology team members
What you’ll need to be successful:
- PhD. in Pharmacology, Biology, or related field with 8+ years post-degree experience with a minimum of 2+ years of program leadership and people management experience
- Experience supporting first-in-class or novel mechanism oncology programs
- Experience working with small molecules, peptides, degraders (e.g., PROTACs), or biologics
- Demonstrated success advancing at least one oncology program to development candidate nomination; experience contributing to an IND submission required
- Strong expertise in in vivo pharmacology, PK/PD modeling concepts, and mechanistic biomarker strategy
- Proven ability to independently design and interpret studies that support program milestones
- Demonstrated ability to utilize AI tools for day-to-day work; baseline proficiency is expected, and advanced or innovated use of AI is a strong plus
- Able to work on-site and attend in-person meetings
- Enthusiastic and innovative mindset with the ability to thrive in a dynamic, fast-paced, and highly collaborative environment
- Excellent communication, organization, multi-tasking, flexibility, and team skills.
Core Values
Parabilis is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.
- Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
- In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
- Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
- All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.
The base salary target for this position is $165,000 - $200,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.
Associate Director, Pharmacology in Cambridge employer: Parabilis Medicines
Parabilis Medicines is an exceptional employer, offering a dynamic and collaborative work environment in the heart of Cambridge, MA, where innovation thrives. Employees benefit from a comprehensive compensation package, including competitive salaries, bonuses, equity, and a strong focus on personal and professional growth. With a commitment to pioneering transformative therapeutics, Parabilis fosters a culture of curiosity and teamwork, making it an inspiring place for scientists eager to make a meaningful impact in the field of biopharmaceuticals.
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We think this is how you could land Associate Director, Pharmacology in Cambridge
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We think you need these skills to ace Associate Director, Pharmacology in Cambridge
Some tips for your application 🫡
Showcase Your Relevant Experience:When applying for a role in the pharmaceutical industry, it's crucial to highlight any relevant experience you have. Whether that's internships, lab work, or even related coursework, make sure to weave this into your CV and cover letter. We want to see how your background aligns with the role you're applying for at Parabilis Medicines!
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How to prepare for a job interview at Parabilis Medicines
✨Understand the Science
Make sure you brush up on key pharmaceutical concepts and recent developments in the industry. You might get asked some technical questions during the interview at Parabilis Medicines that show your grasp of drug development processes or regulatory requirements, so be ready to discuss them clearly.
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If you have any hands-on experience or internships in a laboratory setting, be sure to highlight these in your responses. Think about the projects you worked on, the methodologies you used, and the impact you made. It's all about telling a story that connects your background to the role you're applying for.
✨Know Their Products
Take some time to familiarise yourself with Parabilis Medicines’s product range and recent breakthroughs. Understanding their portfolio not only shows your enthusiasm for the role but also allows you to ask insightful questions that demonstrate your interest in actively contributing to their projects.
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In a full-time pharmaceutical role, understanding the regulatory landscape is crucial. Prepare for situational questions that may test your problem-solving skills concerning compliance and safety standards. You could be asked how you'd handle a hypothetical issue regarding a drug’s market release, so think through your approach.
