Senior PCB Design Engineer in Oxford

Oxford Nanopore Technologies has developed a new generation of nanopore-based sensing technology for faster, information-rich, accessible and affordable molecular analysis. The first application is DNA/RNA sequencing, and the technology is in development for the analysis of other types of molecules including proteins. The technology is used to understand and characterise the biology of humans and diseases such as cancer, plants, animals, bacteria, viruses, and whole environments.

We are seeking a highly capable Senior PCB Design Engineer to own the design and delivery of complex, mixed-signal and RF printed circuit boards from initial requirements through to production.

About the Role

Are you a hands-on hardware specialist who enjoys taking complex ideas from concept to production? We are looking for a skilled Senior PCB Design Engineer to own the entire hardware lifecycle for our next generation of products. In this role, you won't just route boards—you will architect, simulate, and validate complex mixed-signal, digital, analogue, and RF assemblies. Operating as a critical link between hardware architecture and physical manufacturing, you will use Altium Designer to deliver robust, high-performance designs that succeed on the first spin.

Key Responsibilities

• You will own the end-to-end design cycle, driving excellence across the following stages:
• Translate high-level system requirements into robust architectures, component selections, schematic captures, and complete PCB layouts.
• Apply industry-best practices for high-speed design, signal/power integrity, grounding, stack-up definition, thermal management, and EMC/EMI performance.
• Lead hands-on prototype assembly, laboratory debugging, fault-finding, rework, and full design verification.
• Build with production in mind by embedding Design for Manufacture (DFM) and Design for Test (DFT) principles into every layer.
• Manage libraries, support component selection, navigate obsolescence, and collaborate directly with external fabrication and assembly partners.
• Engage with internal engineering, procurement, and quality teams, while maintaining pristine technical documentation and production release records.
• Contribute to continuous process improvements and provide technical guidance and mentoring to less experienced engineers.

What we’re looking for

• Deep, demonstrable expertise using Altium Designer for schematic capture, complex multi-layer PCB layout, library management, and manufacturing output documentation.
• A proven track record designing complex mixed-signal, high-speed digital, precision analogue, and RF hardware assemblies.
• Experience taking electronic products completely through the design cycle, from a blank page to a scaled production release.
• Strong laboratory debugging and fault-finding capabilities using standard test equipment (oscilloscopes, spectrum analysers, etc.), alongside practical rework skills.
• A strong understanding of component lifecycles, supply chain risk management, and direct vendor liaison.
• Excellent interpersonal skills to collaborate with multi-disciplinary stakeholders and confidently mentor less experienced team members.

If you are ready to own impactful hardware designs and elevate our PCB engineering standards, we want to hear from you. We offer outstanding benefits to include an attractive bonus, generous pension contributions, private healthcare and an excellent starting salary. Based within beautiful, landscaped surroundings with tree-lined walks, water features and a lake, all of which make for a wonderful working environment. If you are looking to utilise your skills to really make a difference to humankind, then consider joining our team and apply today!