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- Tasks: Conduct lab activities for lentiviral vector process development and collaborate with cross-functional teams.
- Company: Leading biotechnology firm focused on cell and gene therapy innovations.
- Benefits: Competitive salary, health benefits, and opportunities for professional growth.
- Why this job: Join a dynamic team and contribute to groundbreaking advancements in gene therapy.
- Qualifications: BSc, MSc or PhD in biological sciences with relevant lab experience.
- Other info: Fast-paced environment with excellent career progression opportunities.
The predicted salary is between 36000 - 60000 £ per year.
Location: London, UK (Laboratory based role)
Reporting to: Principal Scientist, Global Technical Development
Job Summary
The Scientist I will independently perform laboratory-based activities supporting lentiviral vector (LVV) process development. The role involves execution of upstream and downstream process studies, vector analytics, and generation of high-quality technical documentation, while collaborating with cross-functional teams to support development, technology transfer, and CMC deliverables across the programmes.
Key Elements and Responsibilities
- Independently perform assigned laboratory activities for lentiviral vector (LVV) manufacturing process, including upstream process (USP) operations and/or downstream process (DSP) operations.
- Perform analysis of LVV samples generated from assigned studies and ensure that experimental results are maintained in relevant databases.
- Design and execute experiments with guidance where required, including data analysis and interpretation. Present experimental results and development updates to the wider department or functional teams as requested.
- Author, review and data-check development protocols and technical reports, ensuring documentation quality is suitable for internal use and regulatory submission.
- Contribute to vector laboratory upkeep, including routine laboratory and equipment maintenance, material ordering and inventory management, in line with safety and quality standards.
- Contribute to capability-building initiatives, including development and application of scale-down models for suspension LVV processes.
- Support process characterization and validation activities ahead of PPQ, in alignment with current industry standards, CMC regulatory expectations and best practices in cell and gene therapy.
- Collaborate with process research, pre-clinical, QA, MSAT and other departments to support delivery of project timelines and milestones.
Required Knowledge
- Approximately 2 to 5 years' experience in biotechnology/biological sciences, with a primary focus on cell and gene therapy.
- Experience in Upstream Process (USP) operations for vector production for adherent and/or suspension cell-based platforms.
- Experience in Downstream Process (DSP) operations including clarification/filtration, chromatography, tangential flow filtration and sterile steps.
- Understanding of analytical methods associated with gene therapy vectors and/or autologous gene-modified cellular therapies.
- Basic understanding of regulatory filings and associated reports/sections writing and knowledge of FDA, EMA, GMP and ICH regulatory requirements.
Skills and Abilities
- Excellent interpersonal skills
- Positive can-do attitude
- Outstanding organizational skills
- Excellent written and oral communication skills
- Creative problem solver
- Ability to operate in a fast-paced, multi-disciplinary industrial environment
Education
- BSc, MSc or PhD in bioprocessing, biological sciences, gene therapy or related subject.
Scientist I, Global Technical Development in London employer: Orchard Therapeutics
Contact Detail:
Orchard Therapeutics Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Scientist I, Global Technical Development in London
✨Tip Number 1
Network like a pro! Reach out to professionals in the biotech field, especially those working with lentiviral vectors. Attend industry events or webinars to make connections and learn about potential job openings.
✨Tip Number 2
Show off your skills! Prepare a portfolio showcasing your lab work, experiments, and any relevant projects. This will help you stand out during interviews and give hiring managers a glimpse of what you can bring to the table.
✨Tip Number 3
Practice makes perfect! Conduct mock interviews with friends or mentors to refine your responses. Focus on articulating your experience with upstream and downstream processes, as well as your understanding of regulatory requirements.
✨Tip Number 4
Don’t forget to apply through our website! We’ve got loads of opportunities waiting for you. Plus, it’s a great way to ensure your application gets noticed by the right people.
We think you need these skills to ace Scientist I, Global Technical Development in London
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to the Scientist I role. Highlight your relevant experience in biotechnology and any hands-on work with upstream and downstream processes. We want to see how your skills match what we're looking for!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you're passionate about cell and gene therapy and how your background makes you a great fit for our team. Keep it engaging and personal – we love to see your personality!
Showcase Your Technical Skills: In your application, don’t forget to mention specific technical skills and experiences that relate to LVV process development. Whether it's your experience with bioreactors or vector analytics, we want to know what you bring to the table!
Apply Through Our Website: We encourage you to apply directly through our website. It’s the best way to ensure your application gets into the right hands. Plus, it shows us you’re serious about joining our awesome team at StudySmarter!
How to prepare for a job interview at Orchard Therapeutics
✨Know Your Science
Make sure you brush up on your knowledge of lentiviral vector processes, both upstream and downstream. Be ready to discuss your hands-on experience with bioreactors and filtration techniques, as well as any analytical methods you've used in gene therapy.
✨Showcase Your Problem-Solving Skills
Prepare examples of how you've tackled challenges in the lab. Think about specific experiments where you had to adapt or innovate, and be ready to explain your thought process and the outcomes.
✨Communicate Clearly
Since you'll be collaborating with cross-functional teams, practice articulating your ideas and results clearly. Consider how you would present complex data to someone outside your field, and be prepared for questions about your communication style.
✨Understand Regulatory Standards
Familiarise yourself with FDA, EMA, and GMP guidelines relevant to gene therapy. Being able to discuss how these regulations impact your work will show that you're not just technically skilled but also aware of the broader context of your role.
