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- Tasks: Support lab activities in lentiviral vector process development and collaborate with cross-functional teams.
- Company: Leading biotech firm focused on innovative gene therapy solutions.
- Benefits: Competitive salary, hands-on experience, and opportunities for professional growth.
- Why this job: Join a dynamic team and contribute to groundbreaking advancements in gene therapy.
- Qualifications: BSc in biological sciences or related field; lab experience preferred.
- Other info: Fast-paced environment with excellent career development opportunities.
The predicted salary is between 36000 - 60000 £ per year.
Location: London, UK (Laboratory based role)
Reporting to: Principal Scientist, Global Technical Development
Job Summary
Reporting to the Principal Scientist, Global Technical Development, the Associate Scientist will contribute towards laboratory-based activities supporting lentiviral vector (LVV) process development. Under supervision, the Associate Scientist will execute upstream and downstream process studies, vector analytics, and generation of high-quality technical documentation, while collaborating with cross-functional teams to support development, technology transfer, and CMC deliverables across the programmes.
Key Elements and Responsibilities
- Support execution of upstream process (USP) (e.g. cell expansion in shake flasks and bioreactor(s), transfection, enhancement and nuclease treatment) and/or downstream process (DSP) (e.g. harvest/clarification, tangential flow filtration, chromatography and sterile filtration) experimentation under supervision.
- Assist in analysis of LVV samples generated, data compilation within relevant databases and data checking for integrity.
- Support authoring or data checking of development protocols and reports ensuring documentation quality is suitable for internal use and regulatory submission with appropriate review.
- Lab maintenance.
- Support in authoring or review of standard operating procedures and/or risk assessments for vector equipment as and when required.
Broader Technical Development & CMC Exposure
- Potentially participate in CMC vector sub-team and cross-functional activities particularly where development activities are conducted in-house.
- May be required to support CMC activities including compilation of data from batch records, generation of source documents and/or conducting DI checks.
- Other activities may be assigned.
Requirements
Required Knowledge
- Experience in biotechnology/biological sciences or equivalent. Experience in cell and gene therapy is highly desirable.
- Understanding of vector manufacturing process operations including cell culture (adherent and/or suspension platforms), filtration, chromatography and tangential flow filtration operations. Practical experience in at least 2 of the above process steps is required.
- Understanding of analytical methods associated with gene therapy vectors and/or autologous gene-modified cellular therapies. Practical experience in vector analytics is highly desirable.
- Confident in performing various laboratory techniques, especially in aseptic culturing, with the ability to quickly learn and develop new practical skills.
Skills and Abilities
- Excellent interpersonal skills.
- Outstanding organizational skills.
- Excellent written and oral communication skills.
- Creative problem solver.
- Ability to operate in a fast-paced, multi-disciplinary industrial environment.
Education
A minimum of BSc or equivalent in bioprocessing, biological sciences, gene therapy or related subject.
Associate Scientist, Global Technical Development (Hiring Immediately) in London employer: Orchard Therapeutics
Contact Detail:
Orchard Therapeutics Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Associate Scientist, Global Technical Development (Hiring Immediately) in London
✨Tip Number 1
Network like a pro! Reach out to professionals in the biotech field on LinkedIn or at industry events. A friendly chat can lead to opportunities that aren’t even advertised yet.
✨Tip Number 2
Prepare for interviews by practising common questions and showcasing your lab skills. We recommend setting up mock interviews with friends or mentors to boost your confidence.
✨Tip Number 3
Don’t forget to follow up after interviews! A quick thank-you email can leave a lasting impression and show your enthusiasm for the role.
✨Tip Number 4
Apply through our website for the best chance of landing that Associate Scientist role. We love seeing candidates who are genuinely interested in joining our team!
We think you need these skills to ace Associate Scientist, Global Technical Development (Hiring Immediately) in London
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to the Associate Scientist role. Highlight your experience in biotechnology and any relevant lab techniques you've mastered. We want to see how your skills align with our needs!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you're passionate about gene therapy and how your background makes you a great fit for our team. Keep it engaging and personal – we love to see your personality!
Showcase Your Lab Experience: Since this is a lab-based role, be sure to detail your hands-on experience with upstream and downstream processes. Mention specific techniques you've used, like cell culture or chromatography, to show us you're ready to hit the ground running.
Apply Through Our Website: We encourage you to apply directly through our website. It’s the best way to ensure your application gets into the right hands. Plus, it shows us you’re keen on joining the StudySmarter family!
How to prepare for a job interview at Orchard Therapeutics
✨Know Your Science
Make sure you brush up on your knowledge of biotechnology and biological sciences, especially around cell and gene therapy. Be ready to discuss specific processes like upstream and downstream operations, as well as vector analytics. This will show that you're not just familiar with the theory but can also apply it practically.
✨Showcase Your Lab Skills
Prepare to talk about your hands-on experience in the lab. Highlight any practical skills you have in aseptic culturing, filtration, or chromatography. If you've worked with lentiviral vectors before, make sure to mention that too! Real examples will help you stand out.
✨Communicate Clearly
Since this role involves collaboration with cross-functional teams, practice articulating your thoughts clearly and concisely. You might be asked to explain complex concepts, so being able to communicate effectively is key. Consider doing mock interviews with a friend to refine your delivery.
✨Be Ready for Problem-Solving Questions
Expect some scenario-based questions where you'll need to demonstrate your creative problem-solving skills. Think of past challenges you've faced in the lab and how you overcame them. This will show your potential employer that you can think on your feet and adapt in a fast-paced environment.