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- Tasks: Conduct lab activities for lentiviral vector process development and collaborate with cross-functional teams.
- Company: Leading biotechnology firm focused on cell and gene therapy innovations.
- Benefits: Competitive salary, health benefits, and opportunities for professional growth.
- Why this job: Join a dynamic team and contribute to groundbreaking advancements in gene therapy.
- Qualifications: 2-5 years in biotechnology, experience in upstream and downstream processes preferred.
- Other info: Fast-paced environment with excellent career progression opportunities.
The predicted salary is between 36000 - 60000 £ per year.
Location: London, UK (Laboratory based role)
Reporting to: Principal Scientist, Global Technical Development
Job Summary
The Scientist I will independently perform laboratory-based activities supporting lentiviral vector (LVV) process development. The role involves execution of upstream and downstream process studies, vector analytics, and generation of high-quality technical documentation, while collaborating with cross-functional teams to support development, technology transfer, and CMC deliverables across the programmes.
Key Elements And Responsibilities
- Independently perform assigned laboratory activities for lentiviral vector (LVV) manufacturing process. This may include upstream process (USP) operations (e.g. cell expansion in shake flasks and bioreactor(s), transfection, enhancement and nuclease treatment) and/or downstream process (DSP) operations (e.g. harvest/clarification, tangential flow filtration, chromatography and sterile filtration).
- Perform analysis of LVV samples generated from assigned studies. Ensure that experimental results are maintained in relevant databases.
- Design and execute experiments with guidance where required, including data analysis and interpretation. Present experimental results and development updates to the wider department or functional teams as requested.
- Author, review and data-check development protocols and technical reports, ensuring documentation quality is suitable for internal use and regulatory submission with appropriate review.
- Contribute to vector laboratory upkeep, including routine laboratory and equipment maintenance, material ordering and inventory management, in line with safety and quality standards.
- Contribute to capability-building initiatives, including development and application of scale-down models for suspension LVV processes, supporting process understanding and optimization at larger scale.
- Support process characterization and validation activities ahead of PPQ, in alignment with current industry standards, CMC regulatory expectations and best practices in cell and gene therapy.
- Involved in development, integration and implementation of (new) vector processes either at OTL labs or at external partners (e.g. CDMOs). This may include technology transfer initiatives between laboratories.
- Potentially participate in early-phase CMC program team activities, including cross-functional collaboration, to support completion of key project goals. Support CMC activities as required, including generation of source documents and/or conducting data integrity (DI) checks.
- Collaborate with process research, pre-clinical, QA, MSAT and other departments to support delivery of project timelines and milestones.
Requirements
- Expected approximately 2 to 5 years' experience depending on scope and relevance, in biotechnology/biological sciences, with a primary focus on cell and gene therapy.
- Experience in Upstream Process (USP) operations for vector production for adherent and/or suspension cell-based platforms. Hands-on experience with suspension bioreactors is highly desirable.
- Experience in Downstream Process (DSP) operations including clarification/filtration, chromatography, tangential flow filtration and sterile steps. Practical/hands-on experience with DSP processes is highly desirable.
- Understanding of analytical methods associated with gene therapy vectors and/or autologous gene-modified cellular therapies. Practical experience in vector analytics is highly desirable.
- Capable of independently designing and/or conducting experiments, analyzing data and effectively managing their time.
- Basic understanding of regulatory filings and associated reports/sections writing and knowledge of FDA, EMA, GMP and ICH regulatory requirements a plus.
- DOE, QBD and Benchling experience a plus.
Skills And Abilities
- Excellent interpersonal skills
- Positive can-do attitude
- Outstanding organizational skills
- Excellent written and oral communication skills
- Creative problem solver
- Ability to operate in a fast-paced, multi-disciplinary industrial environment
- Experience authoring development reports preferred
Education
- BSc, MSc or PhD in bioprocessing, biological sciences, gene therapy or related subject.
Scientist I, Global Technical Development in London employer: Orchard Therapeutics - U.S.
Contact Detail:
Orchard Therapeutics - U.S. Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Scientist I, Global Technical Development in London
✨Tip Number 1
Network like a pro! Reach out to professionals in the biotech field, especially those working with lentiviral vectors. Attend industry events or webinars to make connections and learn about potential job openings.
✨Tip Number 2
Prepare for interviews by brushing up on your technical knowledge. Be ready to discuss your hands-on experience with upstream and downstream processes, as well as any relevant analytical methods you've used.
✨Tip Number 3
Showcase your problem-solving skills during interviews. Think of examples where you creatively tackled challenges in the lab, whether it was optimising a process or troubleshooting an experiment.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets noticed. Plus, we love seeing candidates who are proactive about their job search.
We think you need these skills to ace Scientist I, Global Technical Development in London
Some tips for your application 🫡
Tailor Your CV: Make sure your CV is tailored to the Scientist I role. Highlight your experience in biotechnology and any hands-on work with upstream and downstream processes. We want to see how your skills match what we're looking for!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you're passionate about cell and gene therapy and how your background makes you a great fit for our team. Keep it concise but impactful!
Showcase Your Technical Skills: In your application, don’t forget to mention specific technical skills relevant to the role, like your experience with bioreactors or vector analytics. We love seeing candidates who can hit the ground running!
Apply Through Our Website: We encourage you to apply directly through our website. It’s the best way to ensure your application gets into the right hands. Plus, it shows us you’re serious about joining StudySmarter!
How to prepare for a job interview at Orchard Therapeutics - U.S.
✨Know Your Science
Make sure you brush up on your knowledge of lentiviral vector processes, both upstream and downstream. Be ready to discuss your hands-on experience with bioreactors and filtration techniques, as well as any analytical methods you've used in gene therapy.
✨Showcase Your Problem-Solving Skills
Prepare examples of how you've tackled challenges in the lab. Think about specific experiments where you had to adapt or innovate, and be ready to explain your thought process and the outcomes.
✨Communicate Clearly
Practice explaining complex scientific concepts in simple terms. You might need to present your findings or collaborate with cross-functional teams, so being able to communicate effectively is key.
✨Understand Regulatory Standards
Familiarise yourself with FDA, EMA, and GMP guidelines relevant to gene therapy. Being able to discuss how these regulations impact your work will show that you're not just technically skilled but also aware of the broader context.
