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- Tasks: Support lab activities in lentiviral vector process development and collaborate with cross-functional teams.
- Company: Leading biotech firm focused on innovative gene therapy solutions.
- Benefits: Competitive salary, hands-on experience, and opportunities for professional growth.
- Why this job: Join a dynamic team and contribute to groundbreaking advancements in gene therapy.
- Qualifications: BSc in biological sciences or related field; lab experience preferred.
- Other info: Fast-paced environment with excellent career development opportunities.
The predicted salary is between 36000 - 60000 £ per year.
Location: London, UK (Laboratory based role)
Reporting to: Principal Scientist, Global Technical Development
Job Summary: The Associate Scientist will contribute towards laboratory-based activities supporting lentiviral vector (LVV) process development. Under supervision, the Associate Scientist will execute upstream and downstream process studies, vector analytics, and generation of high-quality technical documentation, while collaborating with cross-functional teams to support development, technology transfer, and CMC deliverables across the programmes.
Key Elements And Responsibilities
- Assist in lentiviral vector (LLV) laboratory activities including preparation of materials (e.g. buffers and reagents), consumables and equipment for development studies and/or analysis.
- Support execution of upstream process (USP) (e.g. cell expansion in shake flasks and bioreactor(s), transfection, enhancement and nuclease treatment) and/or downstream process (DSP) (e.g. harvest/clarification, tangential flow filtration, chromatography and sterile filtration) experimentation under supervision.
- Assist in analysis of LVV samples generated, data compilation within relevant databases and data checking for integrity.
- Support authoring or data checking of development protocols and reports ensuring documentation quality is suitable for internal use and regulatory submission with appropriate review.
- Contribute to vector laboratory upkeep, including routine laboratory and equipment maintenance, material ordering and inventory management, in line with safety and quality standards.
- Support in authoring or review of standard operating procedures and/or risk assessments for vector equipment as and when required.
- Potentially participate in CMC vector sub-team and cross-functional activities particularly where development activities are conducted in-house.
- May be required to support CMC activities including compilation of data from batch records, generation of source documents and/or conducting DI checks.
- Other activities may be assigned.
Requirements
- Experience in biotechnology/biological sciences or equivalent. Experience in cell and gene therapy is highly desirable.
- Understanding of vector manufacturing process operations including cell culture (adherent and/or suspension platforms), filtration, chromatography and tangential flow filtration operations. Practical experience in at least 2 of the above process steps is required.
- Understanding of analytical methods associated with gene therapy vectors and/or autologous gene-modified cellular therapies. Practical experience in vector analytics is highly desirable.
- Confident in performing various laboratory techniques, especially in aseptic culturing, with the ability to quickly learn and develop new practical skills.
Skills And Abilities
- Excellent interpersonal skills
- Outstanding organizational skills
- Excellent written and oral communication skills
- Creative problem solver
- Ability to operate in a fast-paced, multi-disciplinary industrial environment
Education
- A minimum of BSc or equivalent in bioprocessing, biological sciences, gene therapy or related subject.
Associate Scientist, Global Technical Development employer: Orchard Therapeutics - U.S.
Contact Detail:
Orchard Therapeutics - U.S. Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Associate Scientist, Global Technical Development
✨Tip Number 1
Network like a pro! Reach out to professionals in the biotech field on LinkedIn or at industry events. A friendly chat can lead to opportunities that aren’t even advertised yet.
✨Tip Number 2
Prepare for interviews by practising common questions and showcasing your lab skills. We recommend doing mock interviews with friends or mentors to boost your confidence.
✨Tip Number 3
Showcase your passion for biotechnology! During interviews, share your experiences and projects related to gene therapy or vector analytics. Let them see your enthusiasm!
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets noticed. Plus, we love seeing candidates who are proactive about their job search.
We think you need these skills to ace Associate Scientist, Global Technical Development
Some tips for your application 🫡
Tailor Your CV: Make sure your CV reflects the skills and experiences that match the Associate Scientist role. Highlight any relevant lab work, especially in biotechnology or gene therapy, to show us you’re the right fit!
Craft a Compelling Cover Letter: Your cover letter is your chance to shine! Use it to explain why you're passionate about this role and how your background aligns with our needs. Don’t forget to mention any specific experiences with lentiviral vectors or related processes.
Showcase Your Communication Skills: Since excellent written communication is key for this role, make sure your application is clear and concise. Use proper formatting and check for any typos – we want to see your attention to detail!
Apply Through Our Website: We encourage you to apply directly through our website. It’s the best way for us to receive your application and ensures you’re considered for the role. Plus, it’s super easy!
How to prepare for a job interview at Orchard Therapeutics - U.S.
✨Know Your Science
Make sure you brush up on your knowledge of biotechnology and biological sciences, especially around lentiviral vectors and gene therapy. Be ready to discuss specific processes like cell culture and filtration techniques, as well as any practical experience you have in these areas.
✨Showcase Your Lab Skills
Prepare to talk about your hands-on laboratory experience. Highlight any relevant techniques you've mastered, particularly in aseptic culturing or vector analytics. If you can, bring examples of past projects or experiments that demonstrate your skills and problem-solving abilities.
✨Communicate Clearly
Since excellent communication is key for this role, practice articulating your thoughts clearly and concisely. Be prepared to explain complex scientific concepts in a way that's easy to understand, as you'll need to collaborate with cross-functional teams.
✨Be Organised and Proactive
Demonstrate your organisational skills by discussing how you manage lab maintenance and documentation. Show that you're proactive by sharing examples of how you've contributed to team projects or improved processes in previous roles.
