At a Glance
- Tasks: Lead drug discovery using 3D molecular modelling and support customers with innovative software solutions.
- Company: Optibrium, a pioneering software company in drug discovery based in Cambridge, UK.
- Benefits: Hybrid work model, competitive salary, and opportunities for professional growth.
- Other info: Collaborative environment with opportunities to present at conferences and workshops.
- Why this job: Join a team making a real impact in the pharmaceutical industry with cutting-edge technology.
- Qualifications: PhD in relevant field and experience in molecular modelling and drug design.
The predicted salary is between 60000 - 80000 £ per year.
Founded in 2009 and headquartered in Cambridge, UK, Optibrium develops software and novel technologies to improve the efficiency and productivity of drug discovery. Our solutions support industry-leading research for a global customer base, including top ten pharma and innovative biotech companies.
Optibrium software solutions include:
- StarDrop ™ – A complete package of fully integrated software for multi-objective small molecule design, optimisation, and data analysis;
- Cerella ™ – A unique platform for the imputation of drug discovery data, revealing insights into the best compounds and most valuable experiments;
- BioPharmics ™ – A fast, robust, and accurate 3D ligand- and structure-based design platform that scales from small molecules to large macrocycles.
With a strong track record of translating peer‑reviewed science into successful products and a growing blue‑chip customer base for BioPharmics, we are recruiting a Senior or Principal Scientist – 3D Molecular Modelling to help customers achieve challenging drug discovery objectives and maximise the value of our software.
About the Role
As a Senior or Principal Scientist you will:
- Apply 3D structure‑based and ligand‑based design approaches to lead discovery and optimisation;
- Support current and prospective customers in the effective use of BioPharmics, working with the commercial team to communicate its value clearly and scientifically;
- Use NMR and X‑ray crystallography data in combination with the BioPharmics modelling methods;
- Provide guidance on the development of the BioPharmics platform by identifying unmet customer needs and translating them into product and research opportunities;
- Represent Optibrium’s science and products at conferences, workshops, and customer meetings.
About You
The ideal candidate will have the following experience:
- PhD in computational chemistry, computer science, chemistry, biophysics, or a related discipline;
- Strong understanding of structure‑based and ligand‑based drug design, ideally including experience with macrocycles and peptides;
- Experience with molecular modelling and visualisation platforms, e.g., PyMOL and MOE;
- Experience with structural data (NMR and X‑ray crystallography) applied to molecular design problems;
- A track record of high‑quality peer‑reviewed publications and conference presentations;
- The ability to work effectively with customers, collaborators, and cross‑functional teams.
What We Offer
We offer hybrid.
Senior 3D Modelling Scientist - Hybrid & Flexible employer: Optibrium
Optibrium is an exceptional employer, offering a dynamic work culture that fosters innovation and collaboration in the heart of Cambridge. With a strong commitment to employee growth, we provide opportunities for professional development and the chance to work on cutting-edge technologies that are transforming drug discovery. Our hybrid and flexible working arrangements ensure a healthy work-life balance, making Optibrium an ideal place for those seeking meaningful and rewarding employment in a supportive environment.
