Director, Clinical Immunology in Oxford

OMass Therapeutics is a biotechnology company based in Oxford discovering medicines against highly‑validated target ecosystems, such as membrane proteins or intracellular complexes. The company’s unique OdyssION™ technology platform comprises novel biochemistry techniques, next‑generation native mass spectrometry, and custom chemistry. OMass is advancing a pipeline of small‑molecule therapeutics in rare diseases and immunological conditions that target solute carriers, complex‑bound proteins, and GPCRs. We are seeking a Clinical Immunologist to join our team. You will be part of a dynamic, innovative environment and become an integral part of our vision to address patients’ unmet needs while building Britain’s biggest biotech.

Role Overview

• Partner with the Translational Pharmacology team to shape and deliver the company’s immunology strategy and develop a portfolio of differentiated, commercially viable immunology assets.
• Lead clinical development strategy, planning and execution for OMass pipeline of first‑in‑class immunology assets.
• Contribute to discovery and pre‑clinical plans to deliver development candidates with highly differentiated target product profiles.
• Drive efforts to establish clinical biomarker plans to demonstrate early proof‑of‑mechanism and value generation for early immunology assets.
• Contribute to target identification and selection activities, including patient stratification strategies.

Essential Experience, Skills and Qualities

• MD or MD/PhD with significant experience in immunology and drug development, and a strong track record of advancing novel immunology drug candidates through clinical trials, preferably in a biotech setting.
• Industry recognition as a subject matter expert and extensive knowledge of immunology, particularly in autoimmune diseases.
• Experience in designing and overseeing clinical trials, including familiarity with regulatory requirements.
• Strong communication and interpersonal skills, with the ability to collaborate across multi‑functional teams.
• Strong presentation skills with the ability to present at board level and to external stakeholders with credibility and confidence.
• Strategic thinking capabilities and the ability to identify and solve complex problems.

Role Responsibilities

• Lead all aspects of clinical development planning from phase 1 to registration with a multidisciplinary team for immunology assets, rapidly and efficiently maximizing candidate molecule potential and differentiation with scientific rigor, and delivering critical data required to make decisions at each key milestone.
• Lead a cross‑functional clinical trial team to design and execute high‑quality, innovative clinical studies within governance‑approved timeline and budget commitments, collaborating effectively with internal colleagues and external partners.
• Collaborate with discovery and preclinical teams to develop and deliver insightful translational plans.
• Responsible for presentation of results and updates of projects at project, corporate and scientific meetings.
• Establish and manage relationships with key opinion leaders and patient organisations to gain and incorporate insights to inform clinical strategy and operational decisions.
• Engage in clinical development support across the portfolio.
• Support Business Development, including due diligence activities.

Benefits

• Private Health Insurance
• Health and well‑being cashback scheme
• Life Assurance and Income Protection
• Participation in Employee Equity Scheme
• 25 days annual leave, plus bank holidays
• Pension Scheme offering 6% employer contribution
• Learning and Development Opportunities
• Company social events

EEO Statement

OMass Therapeutics values diversity and is committed to equality of opportunity. We also have a responsibility to ensure that all employees are eligible to work and live in the UK.