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- Tasks: Unlock the human genome's potential to drive breakthroughs in complex diseases.
- Company: Join a pioneering team at the forefront of functional genomics.
- Benefits: Competitive salary, collaborative environment, and opportunities for professional growth.
- Other info: Dynamic role with opportunities to collaborate across disciplines and influence drug discovery.
- Why this job: Make a real impact on health by exploring innovative genomic technologies.
- Qualifications: PhD in functional genomics or related field with relevant assay experience.
The predicted salary is between 50000 - 70000 £ per year.
We are unlocking the power of the human non-coding genome to drive breakthroughs in immune-mediated and complex diseases. We combine high-resolution maps of 3D genome architecture with functional genomics, advanced sequencing technologies, and computational innovation to reveal novel regulatory mechanisms and therapeutic targets.
We are seeking a Scientist/Senior Scientist Functional Genomics to join our growing team and play a key role in building 3D variant-to-gene maps across human disease. The role will allow you to continue evolving our state-of-the-art 3D genome Micro Capture-C (MCC) approach, which measures 3D genome interactions at unparalleled resolution, and help us generate foundational datasets to investigate new disease areas. It will also involve working closely with our computational and drug discovery teams to generate insights from the data and identify a new generation of drug targets via the regulatory genome. This role is ideal for a functional genomics scientist with experience in 3D genomics assays or who has experience in parallel assays investigating the regulatory genome.
Key responsibilities:
- Design and implement studies generating 3D genomics datasets from primary human cells.
- Drive and optimise the next generation of technical advances within MCC and 3D genomics.
- Perform studies using other functional genomics approaches (e.g. ATAC-seq, RNA-seq, CRISPR) to support our variant-to-gene mapping approaches and early target validation projects.
- Collaborate closely across disciplines: Partner with computational scientists to design experiments, define analysis requirements and ensure data generated is of high quality.
- Collaborate with AI / ML engineers on conceptualising models to predict 3D genome interactions.
- Provide and explain foundational datasets to support target discovery.
- Communicate results clearly to scientific and non-scientific audiences, influencing decision-making across discovery programmes.
Required Qualifications and Skills:
Essential
- A PhD in functional genomics, a related discipline or equivalent industry experience.
- Demonstrable experience in one or more of the following assays: 3C based 3D genome assays, ATAC-seq, ChIP-seq or RNA-seq.
- Experience in NGS assay development or optimisation.
- Experience in working with primary cell types or other complex cellular systems.
- Ability to design and run high-quality experiments, interpret data, troubleshoot, and suggest next steps and identify alternative approaches.
- Ability to develop and improve new skills and knowledge necessary to successfully support assigned projects.
- Ability to work independently as well as thrive working in a multidisciplinary team.
- Strong communication skills and ability to communicate complex ideas to specialists and non-specialists.
Desirable
- Experience in GWAS and population genomics.
- Background in applying functional genomics techniques (or similar) to investigate disease biology.
- Knowledge of the drug-discovery process and/or industry experience.
- Development of NGS data analysis strategies and implementations.
Scientist/Senior Scientist in Oxford employer: Nucleome Therapeutics Ltd
Contact Detail:
Nucleome Therapeutics Ltd Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Scientist/Senior Scientist in Oxford
✨Tip Number 1
Network like a pro! Reach out to professionals in the field of functional genomics and 3D genomics. Attend conferences, webinars, or local meetups to connect with potential colleagues and mentors who can give you insider tips on job openings.
✨Tip Number 2
Show off your skills! Create a portfolio showcasing your previous work in 3D genome assays or any relevant projects. This will help you stand out during interviews and demonstrate your hands-on experience in functional genomics.
✨Tip Number 3
Prepare for those tricky interview questions! Brush up on your knowledge of ATAC-seq, RNA-seq, and other relevant techniques. Be ready to discuss how you've applied these methods in past projects and how they relate to the role you're applying for.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets noticed. Plus, it shows you’re genuinely interested in joining our team and contributing to groundbreaking research in the non-coding genome.
We think you need these skills to ace Scientist/Senior Scientist in Oxford
Some tips for your application 🫡
Tailor Your CV: Make sure your CV reflects the specific skills and experiences mentioned in the job description. Highlight your expertise in functional genomics and any relevant assays you've worked with, as this will show us you're a great fit for the role.
Craft a Compelling Cover Letter: Use your cover letter to tell us why you're passionate about 3D genomics and how your background aligns with our mission. Share specific examples of your work that demonstrate your ability to drive technical advances and collaborate across disciplines.
Showcase Your Communication Skills: Since you'll need to communicate complex ideas to various audiences, make sure your application materials reflect your ability to explain scientific concepts clearly. Use straightforward language and avoid jargon where possible to make your points accessible.
Apply Through Our Website: We encourage you to apply directly through our website. This ensures your application gets to the right people quickly and allows us to keep track of all applicants efficiently. Plus, it’s super easy!
How to prepare for a job interview at Nucleome Therapeutics Ltd
✨Know Your Science
Make sure you brush up on the latest advancements in functional genomics and 3D genome architecture. Be prepared to discuss your experience with specific assays like ATAC-seq or RNA-seq, and how they relate to the role. This shows that you're not just familiar with the concepts but can also apply them practically.
✨Showcase Your Collaboration Skills
Since this role involves working closely with computational scientists and AI/ML engineers, be ready to share examples of past collaborations. Highlight how you’ve effectively communicated complex ideas to both specialists and non-specialists, as this will demonstrate your ability to thrive in a multidisciplinary team.
✨Prepare for Problem-Solving Questions
Expect questions that assess your troubleshooting skills and ability to design high-quality experiments. Think of specific challenges you've faced in previous projects and how you overcame them. This will help illustrate your critical thinking and adaptability in a research setting.
✨Communicate Clearly and Confidently
Practice explaining your research and findings in a clear and concise manner. You might need to present complex data to a varied audience, so being able to simplify your explanations without losing the essence is key. Confidence in your communication can make a big difference in how your insights are received.