(Principal) Lead Scientist, BioAI

Your new role: As (Principal) Lead Scientist, you will perform cutting edge analyses of cellular phenotype data derived from ultra-high throughput genetic and compound screens to identify new drug targets for cardiometabolic disease. You will have direct impact on our early pipeline and lead the scientific deliveries from our flagship genome-scale in‑vitro perturbation screens producing high‑content imaging and functional genomics data and help us translate these into compelling drug projects. This is a senior scientific role in which you will have the opportunity to have major impact on our early pipeline and engage directly with senior therapy area disease experts, computational biologists, and engineering teams.

Responsibilities: Your responsibilities will include:

• Scientific leadership and execution of high‑value AI and data analysis projects for target discovery
• Translation of ultra‑high throughput in‑vitro screening analysis results/insights into drug target candidates and pipeline projects
• Systems biology‑guided interrogation of high‑dimensional cell‑painting embeddings & omics (incl. DRUG-seq/perturb-seq) data derived from genetic & chemical perturbations
• Keep pace with cutting edge biology‑focused AI methods and contribute to the development of internal evaluations/benchmarks to keep our models focused on value to our discovery pipeline
• Develop collaborative and strategic relationships with key stakeholders in our therapy areas to ensure alignment with the global Novo Nordisk drug discovery strategy and portfolio
• Provide input to our overall systems biology strategy, including scientific direction and implementation

The role requires up to 10% overnight travel, potentially international.

Your new department: You will join the BioAI department, part of AI and Digital Innovation in Research & Development (R&D). BioAI is a global department with colleagues in Denmark, the United Kingdom, and the United States. Our scientists have significant expertise across a diverse set of disciplines in machine learning, graph data science, computer vision, and agentic reasoning, all applied to impacting early target discovery. Driving data‑first decision making in our R&D pipeline is a key objective for BioAI as we seek to strengthen the Novo Nordisk portfolio and deliver new medicines for patients across our core cardiometabolic disease areas.

Your skills & qualifications: To succeed in the role, we expect you to have:

• Master’s degree is a must, and PhD is strongly preferred in cellular/molecular/computational biology or similar preferably combined with several years of experience in a pharma/tech bio context
• Scientific leadership experience in cross‑functional teams with a track record of progressing novel biological hypotheses, ideally focused on drug target identification within a pharma industry context
• Experience applying cutting edge AI and systems biology methods to generate, analyse, and interpret high‑dimensional datasets, preferably from HCI/omics data on in‑vitro genetic/compound screens
• Independence and motivation to perform in‑depth biology‑focused data analysis and work with project and leadership teams to progress targets
• Experience working in Python/R to curate and analyse data
• Experience in CMD‑relevant cellular/molecular biology is an advantage
• Excellent written and oral communication skills, detail oriented with strong presentation and documentation skills

Working at Novo Nordisk: Every day we seek the solutions that defeat serious chronic diseases. To do this, we approach our work with determination, constant curiosity and a commitment to finding better ways forward. For over 100 years, this dedication has driven us to build a company focused on lasting change for long‑term health. One where diverse thinking, shared purpose and mutual respect come together to create extraordinary results. When you join us, you’re not just starting a job – you’re becoming part of a story that spans generations.

What we offer: There is, of course, more on offer here than the uniqueness of our culture and the extraordinary results we produce. Being part of a global healthcare company means opportunities to learn and develop are all around us, while our benefits are designed with your career and life stage in mind.

Application Support: We are an equal opportunities employer, and we commit to an inclusive recruitment process and equality of opportunity for all our job applicants. If you’re a person with a disability, if you’re neurodivergent, and need any adjustments to be made during the application and selection process, please send an email to ebhn@novonordisk.com. Please include your name, the role you are interested in and the type of adjustment your need.

More information: For further information, please reach out to Robert Kitchen, Head of BioAI at JZRK@novonordisk.com.

Deadline: 1 February 2026 (Applications are reviewed on an ongoing basis).