Senior Scientist I, Lentiviral Vector Purification and Analytics

The Lentiviral Vector (LVV) Team in the Biologics Research Center (BRC) at Novartis, Cambridge, MA is seeking a highly motivated Scientist with experience in production and purification of viral vectors to join our team. In this role, you will play a key part in advancing our Cell and Gene Therapy research initiatives and contributing to groundbreaking research in CAR-T cell therapy.

This is a lab-based position that requires hands-on execution of activities related to lentiviral vector purification including clarification, chromatography and TFF. Key responsibilities include:

• Execute analytical methods (molecular- and cell-based) to assess quality of the purified vector.
• Write and review protocols, technical reports, and technology transfer documents with supported conclusions and recommendations.
• Write and review SOPs, instrument procedures, and other lab documents.
• Plan and prioritize work to meet goals while managing multiple research activities.
• Support experimental design, data analysis, and troubleshooting.
• Identify root causes, implement solutions, and verify effectiveness.
• Present scientific data and contribute openly to discussions.
• Document experimental procedures and processes thoroughly.
• Collaborate across teams, share knowledge, and train team members in technical areas as needed.

Essential Requirements:

• BS or MS in bioengineering, virology, or related field with relevant lab experience.
• Six years (with BS) or four years (with MS) of postgraduate experience in viral vector purification.
• BSL2 experience with AAV, lentiviral, or retroviral vector production.
• Proficiency in aseptic technique, cell culture, molecular biology, and analytical testing.
• Expertise in operating different scales of bioreactors for viral vector production.
• Hands-on experience with chromatography and familiar with AKTA operation.
• Familiar with various downstream process techniques, including but not limited to depth filtration, ultrafiltration, diafiltration, tangential flow filtration, etc.
• Strong coordination, communication, collaboration, learning agility, and self-motivation.
• Proficiency with Word, Excel, PowerPoint, and GraphPad Prism.
• Excellent oral, written, and interpersonal communication skills.

Desirable Requirements:

• Hands-on experience with Ambr bioreactors.

Compensation and Benefits:

The salary for this position is expected to range between $93,800 and $174,200 USD annually. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

EEO Statement:

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.