About the Role
To strengthen our Drug Substance Process Sciences team, we are seeking a talented and motivated Associate Scientist / Research Scientist to support upstream process development for biologics.
You will contribute to early-stage process development, process optimisation, technology transfer, and manufacturing support activities. Working within a multidisciplinary team, you will help develop scalable mammalian cell culture processes, perform process characterisation and troubleshooting studies, and support the delivery of innovative protein therapeutics.
This is a laboratory-based role offering exposure to advanced cell culture technologies, high-throughput platforms, and bioreactor systems ranging from microscale to pilot scale.
Your Activities
Process Development & Laboratory Operations
· Design, plan, and execute upstream process development studies with minimal supervision.
· Apply QbD and DoE approaches to process optimisation and characterisation.
· Perform mammalian cell culture experiments using shake flasks, Ambr® systems, and laboratory-scale bioreactors.
· Support scale-up, scalability assessments, process troubleshooting, and technology transfer activities.
· Utilise automation and high-throughput technologies to improve workflow efficiency.
· Contribute to evaluation of emerging technologies and platform improvements.
Data Analysis & Scientific Communication
· Analyse and interpret experimental data using appropriate statistical approaches.
· Generate accurate, high-quality scientific data and documentation.
· Prepare technical reports, protocols, presentations, and project summaries.
· Communicate findings and recommendations to project teams and stakeholders.
Collaboration & Compliance
· Collaborate with Cell Line Development, Analytical Sciences, Downstream Development, Manufacturing and external partners.
· Represent Upstream Process Sciences in cross-functional project teams.
· Maintain accurate laboratory records and electronic laboratory notebooks.
· Ensure compliance with HSE, GMP/GSP, quality systems, and data integrity requirements.
· Participate in continuous improvement initiatives and laboratory best practices.
Requirements
Technical Skills & Experience
· Experience in mammalian cell culture and biologics process development.
· Hands-on experience with CHO cell culture and therapeutic protein production.
· Experience operating Ambr® and/or laboratory-scale bioreactor systems.
· Knowledge of cell culture scale-up principles and process characterisation.
· Experience applying DoE and statistical data analysis tools.
· Strong scientific problem-solving and troubleshooting skills.
· Experience with automation, digital tools, and data management systems.
· Understanding of GMP, data integrity, and quality requirements.
Advantageous
· Perfusion or ATF process experience.
· Technology transfer and manufacturing support experience.
· Exposure to downstream processing and integrated process development.
Associate Scientist / Research Scientist – Upstream Process Sciences in Slough employer: Next Link
Next Link is an exceptional employer dedicated to empowering women and children affected by domestic abuse in Bristol. With a strong commitment to employee wellbeing, we offer generous benefits such as up to 30 days of annual leave, excellent training opportunities, and a supportive work culture that values personal growth and community impact. Join us in making a meaningful difference while enjoying a flexible work environment and a focus on health and wellbeing.
