drugs shown to be effective in treating obesity via glucagon-like peptide-1 receptor agonists (GLP-1RAs) may themselves have a beneficial therapeutic effect on PsA disease activity, The successful applicant will help deliver a multi-centre, prospective, longitudinal experimental medicine study deploying an IL-17 inhibitor and a GLP-1RA as "molecular scalpels" for evaluating tissue and peripheral molecular signatures associated with weight loss and immunomodulation in obese people with PsA,This post provides a unique opportunity for an ambitious clinician to develop a practical understanding of experimental medicine research in Rheumatology and Dermatology, The Clinical Research Associate (CRA) will be responsible for delivering the aforementioned study but will also have opportunities to contribute to other early phase and experimental medicine trials and explore their own research interests.You will join a diverse community of colleagues spanning the Musculoskeletal Disease and
Inflammation Medicine and Skin, Oral and Immunogenomics Themes of the NIHR Newcastle Biomedical Research Centre. Contributing to our world-leading translational research programme. Based in the William Leech Building of Newcastle University's Medical School, your clinical work will take place across Newcastle Hospitals, including the NIHR Newcastle Clinical Research Facility. (NCRF). You will play a central role in the team undertaking this important experimental medicine study, acting as a liaison between the research laboratory team, the NHS rheumatology/dermatology teams and the NCRF. The postholder will be responsible for identifying potential participants via face-to-face and telephone consultations, explaining the study to them, and obtaining consent. You will develop skills in minimally invasive skin, joint and adipose biopsy techniques. You will also have responsibility for local study management and logistics, including oversight of study visits, preparing study reports and manuscripts.
We have a well-staffed laboratory infrastructure and there may also be the possibility to develop laboratory skills, dependent on further funding.You will hold a medical degree, General Medical Council registration and a license to practice in the UK. You are a dynamic, conscientious, self-motivated team player, with a thirst for new knowledge and an appetite for discovery. This post is funded for one year but will provide an excellent platform for a research fellowship, potentially leading to a higher degree, depending on the successful candidate. You will work closely with various members of our collaborating teams, particularly Dr Arthur Pratt, The post is fixed term for a period of 12 months
Please note that before commencing in the role, an Honorary Contract pre-employment check will be required. As part of our commitment to career development for research colleagues, the University has developed 3 levels of Research Innovation Role Profiles.pdf.
team at the NCRF, Rheumatology and Dermatology Research Delivery teams and Musculoskeletal research Group laboratory. Ensure that, once collected, research samples are processed and stored appropriately, according to the standard operating procedure.
Attend Trial Management Group meetings. When appropriate, develop study reports and prepare data for publication in relevant conferences and/or journals.
Provide guidance to other staff and students, potentially including supervision of undergraduate research project students. Attend and present your work at laboratory, and national/international meetings. Be prepared to contribute to events celebrating the public engagement of science/social sciences/humanities.
The Person
Knowledge, Skills and Experience
Essential
- Knowledge of immune-mediated rheumatic and skin diseases.
- Core clinical skills including phlebotomy.
- Analytical and problem-solving capability.
- Ability to communicate complex information with clarity, both verbally and in writing.
- Ability to work independently and as part of a team.
- Oral presentations at internal and/or external medical or scientific meetings.
- Excellent IT skills.
Desirable
- Experience of collecting biological samples for research.
- Previous experience/involvement with clinical and/or translational research.
- Experience of medical statistics or bioinformatics.
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Clinical Research Associate in City of London employer: Newcastle University
Newcastle University is an exceptional employer that fosters a vibrant and inclusive work culture, encouraging creativity and collaboration among its team members. With a strong commitment to employee growth, you will have access to professional development opportunities and the chance to work on impactful projects that enhance the university's reputation. Located in the heart of Newcastle, you'll enjoy a dynamic environment that values innovation and offers a fulfilling career path in the education sector.
