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- Tasks: Join a cutting-edge research team to explore co-transcriptional splicing mechanisms.
- Company: MRC Laboratory of Molecular Biology, a leader in scientific research.
- Benefits: Generous salary, 40.5 days holiday, pension scheme, and training opportunities.
- Why this job: Make a real impact in molecular biology and advance your research skills.
- Qualifications: PhD in biological sciences or nearing completion; strong structural biology background.
- Other info: Inclusive environment welcoming diverse candidates and offering excellent career development.
The predicted salary is between 42694 - 42694 £ per year.
We are recruiting a Postdoctoral Researcher to join Dr Suyang Zhang’s group to investigate the mechanism of co‑transcriptional splicing. The project aims to understand the mechanism of crosstalk between the transcription and splicing machineries using a combined biochemical and structural approach with a focus on cryo‑EM and isolation from endogenous sources.
In eukaryotes, RNA synthesis and splicing are intricately coupled to each other to enhance the efficiency and accuracy of pre‑mRNA processing. Despite advances in our understanding of transcription and splicing as two separate processes, the molecular mechanisms underlying co‑transcriptional splicing in a cellular context remain to be elucidated. We have defined the structural basis for the co‑transcriptional recruitment of U1 snRNP (Science 2021, Nature comms 2025), which provided a model of how distant intron ends can be functionally paired for splicing. Additionally, we have discovered a regulatory mechanism that modulates Pol II elongation rate, shedding light on how Pol II speed may change across introns and exons (NSMB 2025).
Candidate requirements:
- PhD in biological sciences or completion within 6 months
- Strong background in structural biology, biochemistry or cell biology
- Experience in protein purification and mammalian cell work desirable
- Ability to work independently and good communication skills for teamwork
This is a three‑year training and development position suitable for recently completed doctoral graduates or those looking to move into a new research discipline, or to further develop research skills.
Benefits include a defined benefit pension scheme, a holiday entitlement of 40.5 days (including bank holidays and privileged days) and a generous employee discount scheme. We are also committed to providing training and development opportunities including support towards role‑related qualifications.
Closing date: 11th February 2026. Final appointments will be subject to a pre‑employment screening. We actively support equality, diversity and inclusion in our activities, processes and culture. We encourage applications from all sections of society. The LMB particularly welcomes women, minority ethnic and disabled candidates to apply for this vacancy as they are currently under‑represented. We are a disability inclusive employer and encourage disabled people to apply for this role. You are very welcome to contact us for information about the application process and any adjustments you may require; recruit@mrc-lmb.cam.ac.uk.
Postdoctoral Researcher - Structural Studies - Dr Suyang Zhang - LMB 2761 employer: MRC Laboratory of Molecular Biology.
Contact Detail:
MRC Laboratory of Molecular Biology. Recruiting Team
StudySmarter Expert Advice 🤫
We think this is how you could land Postdoctoral Researcher - Structural Studies - Dr Suyang Zhang - LMB 2761
✨Tip Number 1
Network like a pro! Reach out to your connections in the field, attend relevant seminars or workshops, and don’t be shy about introducing yourself to researchers at conferences. You never know who might have a lead on a position or can put in a good word for you.
✨Tip Number 2
Prepare for those interviews! Research Dr Suyang Zhang’s work and the lab’s recent publications. Be ready to discuss how your skills in structural biology and biochemistry can contribute to their projects. Show them you’re not just a fit on paper but also in passion and knowledge.
✨Tip Number 3
Don’t underestimate the power of follow-ups! After an interview or networking event, drop a quick thank-you email to express your appreciation and reiterate your interest in the position. It keeps you fresh in their minds and shows your enthusiasm.
✨Tip Number 4
Apply through our website! We’ve got all the latest opportunities listed there, and it’s the best way to ensure your application gets seen. Plus, it shows you’re proactive and serious about joining our team!
We think you need these skills to ace Postdoctoral Researcher - Structural Studies - Dr Suyang Zhang - LMB 2761
Some tips for your application 🫡
Tailor Your Application: Make sure to customise your CV and cover letter for the Postdoctoral Researcher role. Highlight your relevant experience in structural biology, biochemistry, or cell biology, and don’t forget to mention any specific skills that align with Dr Suyang Zhang’s research focus.
Showcase Your Skills: We want to see your strengths! Include examples of your work in protein purification and mammalian cell work if you have them. This is your chance to shine, so be specific about your contributions and achievements in previous roles.
Keep It Clear and Concise: When writing your application, clarity is key. Use straightforward language and avoid jargon where possible. We appreciate a well-structured application that makes it easy for us to see why you’re a great fit for the team.
Apply Through Our Website: Don’t forget to submit your application through our official website! It’s the best way to ensure your application gets to us directly. Plus, you’ll find all the details you need about the role and our team there.
How to prepare for a job interview at MRC Laboratory of Molecular Biology.
✨Know Your Research
Make sure you’re well-versed in Dr Suyang Zhang’s work and the specifics of the project. Familiarise yourself with the latest publications, especially those related to co-transcriptional splicing and structural biology. This will not only show your genuine interest but also help you engage in meaningful discussions during the interview.
✨Showcase Your Skills
Prepare to discuss your PhD research and how it relates to the position. Highlight your experience in structural biology, biochemistry, or cell biology, and be ready to provide examples of your work with protein purification and mammalian cells. Specific anecdotes can make your skills more relatable and memorable.
✨Ask Insightful Questions
Prepare thoughtful questions about the research group and the project. Inquire about the team dynamics, ongoing projects, or future directions of the research. This demonstrates your enthusiasm and helps you assess if the environment is a good fit for you.
✨Emphasise Teamwork and Independence
Since the role requires both independent work and collaboration, be ready to discuss how you balance these aspects. Share examples of past experiences where you successfully worked in a team while also taking initiative on your own projects. This will highlight your adaptability and communication skills.
