Postdoctoral Scientist - Structural Studies - Dr Chris Tate - LMB 2763 in Cambridge

A postdoctoral position is available immediately to work within a Wellcome Trust funded consortium on human pathogenic fungi. The role is to understand the molecular basis of signalling in Aspergillus fumigatus through the structure determination of membrane protein complexes by electron cryomicroscopy (cryo-EM). Structures will be used to screen virtual libraries of small molecules to develop specific inhibitors that will be tested for efficacy in models of fungal pathogenicity and virulence. The successful candidate will be appointed to one of our postdoctoral training schemes or at an Investigator Scientist level, depending on skills and experience.

Responsibilities

• Contribute to a project on the structural basis of signalling in Aspergillus fumigatus using cryo-EM to determine membrane protein complexes.
• Use determined structures to screen virtual libraries of small molecules and develop specific inhibitors.
• Test inhibitors for efficacy in models of fungal pathogenicity and virulence.
• Work within a collaborative, close-knit team of scientists and participate in project conception to completion.

Qualifications

Postdoctoral training scheme appointment (3 years): You should have a PhD in a relevant subject or be due to complete your PhD within 6 months. You will also have some relevant experience gained during your PhD. This 3-year position is suitable for recent doctoral graduates or those moving into a new research discipline to further develop research skills.

Investigator Scientist appointment (5 years): You should have a PhD in a relevant subject and will have significant postdoctoral experience of cryo-EM, eukaryotic expression systems and membrane protein purification. You will also have considerable contributions to published papers. This is a five-year position aligned with external funding.

What we offer

• Opportunity to contribute to a challenging project in a supportive, collaborative environment.
• State-of-the-art facilities on the Cambridge Biomedical Campus with on-site parking, cycle enclosures, and excellent public transport links.
• Staff restaurant with roof terrace, access to a Campus nursery and sports and social facilities.
• Eligibility to join our defined benefit pension scheme and a holiday entitlement of 40.5 days (including bank holidays and privilege days).
• Generous employee discount scheme and training/development opportunities, including support towards role-related qualifications.

Important information

The LMB is a world-class research institute within UK Research and Innovation (UKRI). UKRI comprises nine research councils. More information can be found at www.ukri.org and www.mrc-lmb.cam.ac.uk.

Closing date: 4 March 2026

Pre-employment: Final appointments will be subject to pre-employment screening.

Equality, diversity and inclusion

We actively support equality, diversity and inclusion in all our activities, processes and culture. We encourage applications from all sections of society. The LMB particularly welcomes women, minority ethnic and disabled candidates to apply for this vacancy as they are currently under-represented. We are a disability inclusive employer and encourage disabled people to apply for this role. For information about the application process and any adjustments you may require, contact recruit@mrc-lmb.cam.ac.uk.