Senior Health Economics Manager (Associate Director Health Outcomes Research)

Join one of the UK’s largest and most active HTA & Outcomes Research teams based in Moorgate, London and help secure national access to innovative medicines and vaccines. You will work in a focused sub‑team within a global organisation, collaborating with UK cross‑functional colleagues and external stakeholders, all with a clear goal: improving patients’ lives. Our hybrid working model supports both effective teamwork and your ongoing development.

As a Senior Health Economics Manager, you will:

• Lead the HTA process for a single technology or indication for both the health economic and clinical components, with particular focus on the suitability of the economic argument to support the HTA strategy.
• Develop and adapt materials and evidence generation activities to demonstrate the value of company assets under the JCVI’s remit (vaccines and other). They may also be required to respond to tenders issued by the DHSC.
• With support from a Team Lead, you will be responsible for optimising the submission strategy, ensuring the economic arguments are appropriate, robust and consistent with the clinical data. The dossier must be of high quality and delivered on time. You will also lead post submission activities.
• Devise and lead UK & Ireland value assessment strategies, ensuring economic models and arguments support HTA objectives.
• Lead high‑quality HTA dossier development and the full assessment process (e.g. clarification questions, ACD responses), across both clinical and economic components.
• Guide UK cost‑effectiveness and budget impact models and input into evidence synthesis (e.g. SLRs, NMAs), including use of real‑world data to address evidence gaps.
• Manage external vendors (e.g. model adaptations, SLR/NMA work), ensuring strategic, technical and timeline standards are met.
• Shape global early models and clinical trial design to reflect UK & Ireland requirements and product value propositions.
• Represent the company at NICE and other HTA/JCVI meetings and advisory boards; engage with clinicians, payers, patient groups and other stakeholders to inform strategy.
• Work closely with cross‑functional and pricing colleagues to anticipate appraisal risks and opportunities and ensure alignment across internal and external stakeholders.
• Lead evidence generation activities that address gaps particularly of relevance to HTA/JCVI dossiers.
• Support generation of economic evidence to support lifecycle management, uptake and implementation of novel treatments.
• Contribute to and/or lead health economic methodological research initiatives (e.g. NICE Methods, key issues in oncology modelling).
• Conduct landscape assessments for products in the pipeline, focusing on HTA and health economic risks and mitigations.
• Support New Product Planning colleagues to ensure that HTA requirements are anticipated in the development of UK launch plans.
• Ensure all necessary horizon scanning is up to date.
• Contribute to cross‑functional strategy sessions with medical, marketing, market access, and external affairs colleagues.
• Contribute to the development of technical expertise both within the HTA & OR team and the broader company.
• Keep up to date on best practice statistical and health economic methods, clinical trial design and reporting.
• Coach and mentor health economics managers in the team on technical methods.

Qualifications, Skills & Experience Required:

• Master's degree in Health Economics or related discipline.
• Experience of multiple HTA submissions (should include NICE), including all process milestones.
• Deep knowledge of NICE methods and processes, strong economic modelling knowledge and experience, knowledge of evidence synthesis and outcomes research methods.
• A deep understanding of the NHS and payer systems in the UK.
• Excellent communication skills (verbal and written as well as presentation skills).
• Quantitative and statistical literacy; comfortable working with complex datasets and assumptions; excellent analytical skills.
• Working collaboratively in a matrix organisation.
• Strong organisational and prioritisation skills across multiple concurrent projects.
• Proven ability to lead end‑to‑end HTA projects to tight timelines and high quality.

What we offer:

• The opportunity to be involved in a broad range of therapy areas and a large volume of submission work.
• High levels of autonomy and ownership in developing HTA submission dossiers in-house.
• Involvement in the end-to-end HTA work, from clinical trial design to post‑HTA approval.
• Membership of a global organisation and collaboration with colleagues around the world.
• Have the chance to influence global and local decision making that impacts the lives of thousands of people.
• A supportive and positive company culture.
• Professional development and training opportunities.

Your role at our company is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively for the common good. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.