At a Glance
- Tasks: Lead innovative research in macrophage biology and immune-stromal interactions for drug discovery.
- Company: Engitix, a pioneering biotech company transforming drug discovery in London.
- Benefits: Competitive salary, private medical insurance, pension, bonuses, and employee perks.
- Other info: Opportunity to mentor and lead a team while making a real impact on patient health.
- Why this job: Join a collaborative team shaping the future of targeted therapeutics in a fast-paced environment.
- Qualifications: PhD in Biomedical sciences or related field with significant experience in drug screening.
The predicted salary is between 60000 - 80000 £ per year.
Your mission We are seeking an accomplished Senior scientist of macrophage biology to provide scientific leadership in macrophage biology and immune‑stromal interactions, driving target identification, validation and translational strategy across our fibrosis and oncology discovery portfolio. We are looking for an expert in macrophage biology who will use their experience to establish macrophage‑based target screening assays combined with our novel extracellular matrix‑based cell models, utilising cellular, immunological, biochemical, molecular biology and functional genomic approaches. You will also provide scientific mentorship and technical guidance to scientists across discovery programmes, champion innovative approaches and emerging technologies in macrophage and immune‑stromal biology, and represent macrophage biology expertise within cross‑functional project teams.
Key Responsibilities
- Establish a suite of macrophage functionality assays to target discovery and drug discovery flowcharts, including activation, cytokine secretion, phagocytosis and efferocytosis assays.
- Optimise macrophage target screening‑based systems utilising annotated lmw libraries and functional genomic approaches such as siRNA and CrispR library‑based approaches.
- Lead a small team of immunologists/cell biologists involved in execution of projects across both the internal and external biopartnerships.
- Lead the build novel macrophage drug target nomination packages and present case to the leadership for portfolio entry.
- Analyse, interpret, report and present results.
Your profile
Key Experience
- Demonstrable expertise in macrophage biology, in particular phagocytosis pathways.
- Demonstrable experience in target nomination and validation in a biotech or pharmaceutical based setting.
- Expertise in the use of multi‑colour flow cytometry and IF techniques.
- Hands‑on experience of key immunological and molecular biology techniques including MSD, RNA/DNA extraction, qRT‑PCR, western blotting, siRNA knockdown.
- Have team and direct people leadership experience.
- Familiarity with molecular pharmacology and oncology drug development would be an advantage.
- Prior working experience in the biotech/pharma industry performing laboratory research would be a further plus.
Qualifications and Competencies
- PhD in Biomedical sciences, Immunology, Biochemistry, Biotechnology or related discipline plus 4 years’ experience in drug screening setting or MSc plus 8 years practical experience with a focus on immuno‑oncology or fibrosis.
- Ability to plan, execute and critically assess experiments independently.
- Excellent time‑management skills and ability to work to set deadlines.
- You will be expected to work well within a team, have strong written and verbal communication skills, as well as IT skills.
- You will troubleshoot effectively, work methodically, stay well organised, pay close attention to detail, and maintain accurate records.
Why us?
- Be part of a pioneering biotech transforming drug discovery through ECM biology.
- Work in a collaborative, fast‑paced environment with opportunities to shape the future of targeted therapeutics.
- We offer a competitive package including private medical insurance, pension, bonus, employee perks and more!
About us
Engitix is a growing biotech company based in White City Place, West London. We are dedicated to developing better therapies for advanced fibrosis and solid tumours by leveraging our pioneering extracellular matrix (ECM) platform. Our platform allows the synthesis of realistic in vitro 3D models that serve as tools to transform our ability to identify new targets and biomarkers, determine mechanisms of action and more accurately predict the efficacy of therapeutic candidates. Join us today in our mission to create a healthier future for patients with life‑threatening diseases such as fibrosis and cancer.
Senior Scientist, Macrophage-stromal biology London employer: Meeveem Limited
Engitix is an exceptional employer located in the vibrant White City Place, West London, offering a dynamic and collaborative work environment that fosters innovation in drug discovery. As a Senior Scientist, you will not only lead cutting-edge research in macrophage biology but also benefit from a competitive package that includes private medical insurance, pension, and employee perks, all while contributing to meaningful advancements in therapies for advanced fibrosis and solid tumours. With a strong emphasis on mentorship and professional growth, Engitix provides ample opportunities for you to shape the future of targeted therapeutics and make a significant impact in the biotech field.
StudySmarter Expert Advice🤫
We think this is how you could land Senior Scientist, Macrophage-stromal biology London
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We think you need these skills to ace Senior Scientist, Macrophage-stromal biology London
Some tips for your application 🫡
Show Off Your Lab Skills:In the biotechnology field, it's super important to highlight your lab experience in your CV. Be sure to mention specific techniques or instruments you've mastered (think PCR, gel electrophoresis, etc.) and any relevant projects you've worked on. This will show Meeveem Limited that you have the hands-on skills they need.
Tailor Your Technical Skills:Make sure to emphasise your technical skills, especially those relevant to the biotechnology sector. Include any software tools or programming languages you've used, like R or Python for data analysis, which could be key for this role at Meeveem Limited.
Craft a Compelling Cover Letter:Since this is a full-time role, your cover letter should reflect not only your passion for biotechnology but also your long-term career ambitions. Share why you're excited about the work that Meeveem Limited does and how you envision contributing to their goals. This shows that you’re not just looking for any job, but you're genuinely invested in this opportunity.
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How to prepare for a job interview at Meeveem Limited
✨Brush Up on Lab Techniques
Since you're eyeing a full-time gig in biotechnology, make sure you're well-versed in the lab techniques relevant to the role. Be ready to talk about PCR, CRISPR, or any specific methods mentioned in the job description at Meeveem Limited. You might even be asked to demonstrate your understanding of these processes.
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Get comfortable with bioinformatics tools that are commonly used in the industry, like BLAST or Bioconductor. These are key in biotechnology, and having hands-on experience or at least familiarity can set you apart. Prepare to discuss any relevant projects you've worked on, especially if they involved data analysis or genomic research.
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