Senior Clinical Pharmacologist United Kingdom

Senior Clinical Pharmacologist

ICON is a global healthcare intelligence and clinical research organisation united by a mission to bring new medicines and treatments to patients faster.

As a values-driven organisation, integrity, collaboration, agility, and inclusion are at the heart of how we work and interact with each other, customers, patients and suppliers.

We are currently seeking a Senior Clinical Pharmacologist (Director, Clinical Pharmacology) to join our growing client-dedicated team at ICON.

This is a unique opportunity to become an embedded strategic partner within a leading global pharmaceutical organization, influencing development programs from early research through registration.

As a Senior Clinical Pharmacologist, you will join a highly collaborative client-dedicated team, partnering with scientific and clinical leaders to support clinical pharmacology strategy across programs from early development through registration. You will apply your expertise in clinical pharmacology, biopharmaceutics, and model-informed drug development to drive informed decision-making and accelerate the development of innovative therapies.

What You Will Do

• Lead clinical pharmacology strategies across early and late-phase drug development programs.
• Apply model-informed drug development principles to support dose selection, patient population strategy, biomarkers, and endpoint optimization.
• Partner with Pharmacometricians to develop and execute PK/PD modeling and simulation strategies.
• Contribute to translational medicine initiatives, preclinical study design, and First-in-Human (FIH) studies, including SAD and MAD dose selection.
• Provide clinical pharmacology expertise to cross-functional teams, governance discussions, and key development decision points.
• Support regulatory submissions and responses to health authority queries.
• Drive collaboration across preclinical, clinical, regulatory, and quantitative sciences teams to advance development programs.
• Stay current with emerging innovations in clinical pharmacology, pharmacokinetics, biopharmaceutics, and quantitative drug development.

You Will Have:

• PhD in Biological Sciences, Bioengineering, Pharmacology, Pharmaceutical Sciences, or a related discipline.
• Extensive experience within clinical pharmacology, pharmaceutical development, or a related industry setting.
• Strong hands-on expertise in clinical pharmacology strategy, study design, PK/PD modelling, and quantitative data interpretation.
• Deep understanding of model-informed drug development and its application across the drug development lifecycle.
• Experience supporting translational medicine strategies and early clinical development programs, including FIH studies.
• Strong knowledge of innovative approaches in clinical pharmacokinetics, biopharmaceutics, and PK/PD modelling.
• Comprehensive understanding of global drug development and regulatory requirements.
• Excellent communication and stakeholder management skills, with the ability to influence and build alignment across scientific and business functions.
• Proven ability to lead complex scientific discussions and contribute to strategic development decisions.

Rewards & Benefits

ICON offers a competitive and comprehensive total rewards package designed to support your health, wellbeing, and career development.

Benefits may include:

• Competitive base salary and performance related incentives
• Health and wellbeing programmes including medical, dental, and vision coverage where applicable
• Retirement and pension plans
• Life assurance and disability coverage
• Employee assistance programmes and wellbeing resources
• Learning and development opportunities through structured training and career pathways

Benefits may vary depending on role and location.

ICON is an equal opportunity employer. We are committed to building an inclusive and accessible workplace where everyone feels valued and supported.