At a Glance
- Tasks: Join our team to unlock the human genome and drive breakthroughs in disease research.
- Company: Nucleome Therapeutics, a leader in innovative genomic research.
- Benefits: Competitive salary, inclusive culture, and opportunities for professional growth.
- Other info: Collaborative environment with a focus on cutting-edge technology and research.
- Why this job: Make a real impact in genomics and contribute to groundbreaking discoveries.
- Qualifications: PhD in functional genomics or related field with relevant assay experience.
The predicted salary is between 50000 - 70000 € per year.
About Nucleome Therapeutics: We are unlocking the power of the human non-coding genome to drive breakthroughs in immune-mediated and complex diseases. We combine high-resolution maps of 3D genome architecture with functional genomics, advanced sequencing technologies, and computational innovation to reveal novel regulatory mechanisms and therapeutic targets.
The Role: We are seeking a Scientist/Senior Scientist Functional Genomics to join our growing team and play a key role in building 3D variant-to-gene maps across human disease. The role will allow you to continue evolving our state-of-the-art 3D genome Micro Capture-C (MCC) approach, which measures 3D genome interactions at unparalleled resolution, and help us generate foundational datasets to investigate new disease areas. It will also involve working closely with our computational and drug discovery teams to generate insights from the data and identify a new generation of drug targets via the regulatory genome. This role is ideal for a functional genomics scientist with experience in 3D genomics assays or who has experience in parallel assays investigating the regulatory genome.
Key Responsibilities:
- Design and implement studies generating 3D genomics datasets from primary human cells.
- Drive and optimise the next generation of technical advances within MCC and 3D genomics.
- Perform studies using other functional genomics approaches (e.g. ATAC-seq, RNA-seq, CRISPR) to support our variant-to-gene mapping approaches and early target validation projects.
- Partner with computational scientists to design experiments, define analysis requirements and ensure data generated is of high quality.
- Collaborate with AI / ML engineers on conceptualising models to predict 3D genome interactions.
- Provide and explain foundational datasets to support target discovery.
- Communicate results clearly to scientific and non-scientific audiences, influencing decision-making across discovery programmes.
Required Qualifications and Skills:
Essential:
- A PhD in functional genomics, a related discipline or equivalent industry experience.
- Demonstrable experience in one or more of the following assays: 3C based 3D genome assays, ATAC-seq, ChIP-seq or RNA-seq.
- Experience in NGS assay development or optimisation.
- Experience in working with primary cell types or other complex cellular systems.
- Ability to design and run high-quality experiments, interpret data, troubleshoot, and suggest next steps and identify alternative approaches.
- Ability to develop and improve new skills and knowledge necessary to successfully support assigned projects.
- Ability to work independently as well as thrive working in a multidisciplinary team.
- Strong communication skills and ability to communicate complex ideas to specialists and non-specialists.
Desirable:
- Experience in GWAS and population genomics.
- Background in applying functional genomics techniques (or similar) to investigate disease biology.
- Knowledge of the drug-discovery process and/or industry experience.
- Development of NGS data analysis strategies and implementations.
Nucleome Therapeutics is an equal opportunity employer.
Scientist/Senior Scientist in Oxford employer: Meeveem Limited
Nucleome Therapeutics is an exceptional employer, offering a dynamic work environment where innovation thrives and employees are empowered to make significant contributions to groundbreaking research in genomics. With a strong focus on collaboration and professional development, our team members enjoy access to cutting-edge technologies and the opportunity to work alongside leading experts in the field, all while being part of a mission-driven organisation dedicated to advancing healthcare solutions. Located in a vibrant area, we foster a culture of inclusivity and support, ensuring that every employee can grow and excel in their career.
StudySmarter Expert Advice🤫
We think this is how you could land Scientist/Senior Scientist in Oxford
✨Tip Number 1
Network like a pro! Reach out to people in the industry, attend conferences, and join relevant online forums. We can’t stress enough how valuable personal connections can be in landing that dream role.
✨Tip Number 2
Prepare for interviews by practising common questions and showcasing your expertise in functional genomics. We recommend doing mock interviews with friends or mentors to boost your confidence and refine your answers.
✨Tip Number 3
Showcase your projects! Create a portfolio or presentation that highlights your work in 3D genomics and other relevant assays. We love seeing candidates who can visually communicate their findings and impact.
✨Tip Number 4
Don’t forget to apply through our website! It’s the best way to ensure your application gets noticed. Plus, we’re always on the lookout for passionate scientists ready to make a difference in the field.
We think you need these skills to ace Scientist/Senior Scientist in Oxford
Some tips for your application 🫡
Tailor Your CV:Make sure your CV reflects the skills and experiences that match the Scientist/Senior Scientist role. Highlight your expertise in functional genomics and any relevant assays you've worked with, like 3D genome assays or RNA-seq.
Craft a Compelling Cover Letter:Use your cover letter to tell us why you're passionate about functional genomics and how your background aligns with our mission at Nucleome Therapeutics. Be specific about your experience and how it can contribute to our team.
Showcase Your Communication Skills:Since you'll be communicating complex ideas to various audiences, include examples in your application that demonstrate your ability to explain scientific concepts clearly. This will show us you can bridge the gap between specialists and non-specialists.
Apply Through Our Website:We encourage you to apply directly through our website. It’s the best way for us to receive your application and ensures you’re considered for the role. Plus, it shows us you’re keen on joining our team!
How to prepare for a job interview at Meeveem Limited
✨Know Your Science
Make sure you brush up on the latest advancements in functional genomics and 3D genomics assays. Be ready to discuss your experience with techniques like ATAC-seq, RNA-seq, and CRISPR, as well as how they relate to the role at Nucleome Therapeutics.
✨Showcase Your Problem-Solving Skills
Prepare to share specific examples of how you've designed and run high-quality experiments. Think about times when you faced challenges in your research and how you overcame them—this will demonstrate your ability to troubleshoot and adapt.
✨Collaborate and Communicate
Since this role involves working closely with computational scientists and AI/ML engineers, be ready to discuss your experience in multidisciplinary teams. Highlight your communication skills by explaining complex ideas in simple terms, as you'll need to influence decision-making across various programmes.
✨Stay Curious and Eager to Learn
Nucleome Therapeutics values continuous learning, so express your enthusiasm for developing new skills and knowledge. Share how you've kept up with industry trends or pursued additional training that could benefit your work in functional genomics.
