Senior Scientist/Principal Scientist AI/ML

Maxion Therapeutics is a biotechnology company developing antibody-based drugs for previously untreatable ion channel- and G protein-coupled receptor (GPCR)-driven diseases, including autoimmune conditions, chronic pain, and cardiovascular disease. Maxion is developing a pipeline of potentially first- and best-in-class therapeutics using its proprietary KnotBody® technology to generate potent, selective, and long-acting therapeutics by combining naturally occurring mini-proteins (‘knottins’) with antibodies using state-of-the-art phage and mammalian display technologies.

We are seeking a highly skilled Senior AI Research Scientist with expertise in computational protein design and generative protein modelling to enable AI- and structure-guided approaches to therapeutic antibody and KnotBody design. The successful candidate will drive the development, implementation, deployment and adoption of generative AI/ML models to enable therapeutic protein design, engineering and optimisation, utilising Maxion’s proprietary KnotBody technology.

This is a unique opportunity for someone who is excited to roll up their sleeves, build new capabilities from the ground up, and drive forward discovery programmes. The successful candidate will bring strong technical skills, a collaborative mindset, and the ability to thrive in a fast-paced biotech environment.

• Develop the computational protein design platform through integration, adaptation and benchmarking of generative protein design & engineering tools (AlphaFold/OpenFold, RFDiffusion, ProteinMPNN, Boltz, FrameFlow, etc) into the drug discovery process.
• Build generative and predictive models for protein design by training and fine-tuning ML models (VAEs, diffusion models, transformers) focused on prediction of functional therapeutic proteins and their properties (affinity, stability, and developability).
• Enable computational optimisation of therapeutic proteins, leveraging various ML approaches (genetic algorithms, Bayesian optimisation, physics-based methods, etc.) and integrating experimental data.
• Build datasets, data pipelines, training workflows, and evaluation tools for model training, benchmarking, and continuous learning.
• Cross functional collaboration with internal R&D and discovery teams to translate predictive models into deployable tools and testable experimental hypotheses.

• Ph.D. or MSc. in Computational Biology, Computer Science, Bioinformatics, Natural Sciences or a related subject.
• Strong programming skills in Python and experience with deep learning frameworks (PyTorch, JAX, TensorFlow in order of preference).
• Substantial experience of structural bioinformatics and computational protein design, for example: protein structure modelling & prediction, generative protein sequence & structure design, protein-protein docking, physics-based modelling & simulation, etc.
• Experience training and fine-tuning ML models for protein design or related tasks.
• Experience of integrating computational predictions with experimental validation data for property optimisation.
• Experience working with modern MLOps stacks (Docker, Kubernetes, CI/CD, GitHub, etc.) to deploy and monitor models.
• Experience working with antibody sequence and structure datasets, using in silico tools for predicting protein properties and guiding engineering campaigns.

• Publication(s) in relevant peer-reviewed journals, ideally focused on antibody design, AI/ML based protein modelling, or non-standard scaffolds (e.g. knottins, minibinders, etc.).
• Experience applying generative or structure-based models to challenging target classes (e.g. ion channels, GPCRs).

• A competitive salary based on experience.
• A comprehensive benefits package including generous pension contribution, Private Life and Medical Insurance, Cycle to Work Scheme, participation in the company Share Option Scheme, on site parking and more.
• Significant opportunities for career progression within a dynamic company.
• Located in a state-of-the art Science Park with easy access to Cambridge by car, train and bus, and offering on-site gym, cafe, and a vibrant social community.
• Working alongside an innovative team of scientists, including the founders, who are Key Opinion Leaders in the field.
• A supportive work environment with a key focus on fostering collaborative working environment within a friendly team.

To apply for this position, just click on the link to upload your CV and covering letter outlining your suitability for this role, including your salary expectations. Due to data safety, please do not email or apply via direct messaging. This is a permanent position.